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20,252 grants found
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Science of Community Outreach and Engagement (SoCOE) Conference
PROJECT SUMMARY Community outreach and engagement (COE) has become the gold standard in addressing health disparities and closing the health gaps in minoritized and marginalized co...
Understand the mechanisms through which genetics, biology, and social determinants affect cancer risk and outcomes in diverse populations, to motivate interventions to reduce cancer inequities
Overall Abstract Prostate, breast and pancreatic cancers all have a disproportionately higher rate of aggressive tumor grade and early onset in Black patients, with recent spikes o...
Societal, Ancestry, Molecular and Biological Analyses of Inequalities: SAMBAI
SAMBAI: Societal, Ancestry, Molecular and Biological Analyses of Inequalities Research Abstract Background Prostate, breast, and pancreatic cancers all have a disproportionately hi...
SAMBAI-Columbia
SAMBAI: Societal, Ancestry, Molecular and Biological Analyses of Inequalities Research Abstract Background Prostate, breast, and pancreatic cancers all have a disproportionately hi...
PROTECT - Harnessing PROTEin degradation for Advanced Childhood Tumors
eRA ASSIST for NCI – PROTECT Title: PROTECT – Harnessing PROTEin degradation for Advanced Childhood Tumors Abstract: Background Survival rates for children with solid tumors, inclu...
MATCHMAKERS - large-scale generation of reactive TCR-pMHC pairs from human NSCLC
Abstract Understanding how T cell receptors (TCRs) see tumor antigens presented by MHCs is necessary to fully understand how the immune system recognizes tumor antigens, and to rea...
MATCHMAKERS - Solving T-cell receptor recognition and design via integrated high-throughput screening and structural, functional and computational approaches
Abstract Understanding how T cell receptors (TCRs) see tumor antigens presented by MHCs is necessary to fully understand how the immune system recognizes tumor antigens, and to rea...
MATCHMAKERS - SOLVING TCR RECOGNITION AND DESIGN VIA INTEGRATED HIGH-THROUGHPUT SCREENING, STRUCTURAL, FUNCTIONAL, AND COMPUTATIONAL APPROACHES
Abstract Understanding how T cell receptors (TCRs) see tumor antigens presented by MHCs is necessary to fully understand how the immune system recognizes tumor antigens, and to rea...
Societal, Ancestry, Molecular AND Biological Analyses Of Inequalities (SAMBAI)
SAMBAI: Societal, Ancestry, Molecular and Biological Analyses of Inequalities Research Abstract Background Prostate, breast, and pancreatic cancers all have a disproportionately hi...
PROSPECT: Pathways, Risk factors, and mOleculeS to Prevent Early-onset Colorectal Tumors
ABSTRACT Our vision is to unravel and ultimately reverse the intricate network of causal factors throughout the life course that disrupts biological homeostasis to promote colorect...
PROSPECT: Pathways, Risk factors, and mOleculeS to Prevent Early-onset Colorectal Tumors
ABSTRACT Our vision is to unravel and ultimately reverse the intricate network of causal factors throughout the life course that disrupts biological homeostasis to promote colorect...
SAMBAI - Social, Ancestry, Molecular Biology analyses of Inequities
SAMBAI: Societal, Ancestry, Molecular and Biological Analyses of Inequalities Research Abstract – New York Genome Center Background Prostate, breast, and pancreatic cancers all hav...
SAMBAI: Societal, Ancestry and Molecular Biology Analyses of Inequalities
SAMBAI: Societal, Ancestry, Molecular and Biological Analyses of Inequalities Research Abstract Background Prostate, breast, and pancreatic cancers all have a disproportionately hi...
PROTECT - Harnessing PROTEin degradation for Advanced Childhood Tumors
eRA ASSIST for NCI – PROTECT Title: PROTECT – Harnessing PROTEin degradation for Advanced Childhood Tumors Abstract: Background Survival rates for children with solid tumors, inclu...
MGH- PROSPECT: Pathways, Risk factors, and mOleculeS to Prevent Early-onset Colorectal Tumors
ABSTRACT Our vision is to unravel and ultimately reverse the intricate network of causal factors throughout the life course that disrupts biological homeostasis to promote colorect...
SAMBAI - Yemaachi Biotech
SAMBAI: Societal, Ancestry, Molecular and Biological Analyses of Inequalities Research Abstract Background Prostate, breast, and pancreatic cancers all have a disproportionately hi...
Novel Nanomedicine-Based Therapeutic Approach For Treatment of Cancer Cachexia
Project Summary Cachexia is a debilitating metabolic disorder that affects 50% of all cancer patients. Numerous clinical trials confirmed that the wasting of skeletal muscle mass i...
The histone demethylase JMJD1C in human Acute Myeloid Leukemia
PROJECT SUMMARY Current therapy for acute myeloid leukemia (AML) is inadequate. Despite newly available therapeutics agents, the overall survival rate for patients with the disease...
Targeting Replication Stress and DNA Damage Response in Uterine Cancer
PROJECT SUMMARY Uterine cancer (UC) incidence and death rates are both significantly increasing in the United States. Most UCs are endometrial cancers which arise from the inner li...
Combined ATR and P13k inhibition in uterine cancer
Project Summary Replication stress (RS) is defined as the slowing or stalling of the replication fork progression during DNA synthesis and is widely recognized as a significant cau...