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20,252 grants found
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PROTECT - Develop therapeutics to target oncogenic drivers of solid tumours in children
Title: PROTECT – Harnessing PROTEin degradation for Advanced Childhood Tumors Abstract: Background Survival rates for children with solid tumors, including brain, have largely plat...
Imaging zinc secretion from the exocrine pancreas for the early diagnosis of pancreatic adenocarcinoma with MRI
ABSTRACT This proposal aims to use noninvasive molecular magnetic resonance (MR) imaging of pancreatic zinc content and secretion to detect pancreatic intraepithelial neoplasia (Pa...
CLINICAL TRIALS MONITORING SERVICE
This is a Research and Development Support contract.The purpose of this acquisition is to assist the NCI in fulfilling its responsibilities to the Food and Drug Administration (FDA...
Cancer Genome & Epigenetics
The overall goals of the Cancer Genome & Epigenetics (CGE) Program (formerly Tumor Initiation and Maintenance Program) are to identify the cells that give rise to tumors and th...
Cancer Metabolism & Microenvironment
The overall goal of the Cancer Metabolism & Microenvironment (CMM) Program (formerly Cell and Molecular Biology of Cancer Program) is to generate new knowledge about potential...
Cancer Molecular Therapeutics
The overall goals of the Cancer Molecular Therapeutics (CMT) Program (formerly Aging, Cancer and Immuno-oncology (ACI)) are to engage active collaborations among members of the pro...
American Indian/Alaskan Native Think Tank
ABSTRACT Huntsman Cancer Institute (HCI) has set out to deliver a cancer-free frontier across the Mountain West and beyond. Our Cancer Center’s impact extends throughout the 5-stat...
DNA Repair Deficiencies in Infertile Men and Cancer Risk
There is a need to identify the causes of the most severe form of male infertility, non-obstructive azoospermia (NOA), where there is spermatogenic failure resulting in an ejaculat...
Cancer Center Administration
ADMINISTRATION ABSTRACT Huntsman Cancer Institute (HCI) Administration supports the Cancer Center’s mission to provide excellence in innovative basic, translational, population sci...
Elucidating alternative polyadenylation regulation during prostate cancer progression to castration-resistance
Project Summary/Abstract Alternative polyadenylation (APA) is a major mechanism of posttranscriptional regulation that generates distinct 3′ untranslated regions (3′UTR) on RNA tra...
Ribonucleotide Reductase as a Driver of Breast Cancer Aggressiveness
PROJECT SUMMARY Despite the vast improvement in screening techniques and therapies, breast cancer remains the second leading cause of cancer deaths in females worldwide. Approximat...
Evaluating, Preparing, and Responding to Care Disruptions and Health Outcomes Among Patients with Breast Cancer Following Severe Storms
Project Summary/Abstract Severe storms, whether hurricanes or other storms with significant wind/precipitation, affect millions of Americans each year, disrupt the delivery of heal...
The role of tumor-macrophage hybrid cells in prostate cancer metastasis
ABSTRACT The role of tumor-macrophage hybrid cells in prostate cancer metastasis AR signaling inhibitors (ARSIs) are commonly used to treat recurrent prostate cancer whose growth d...
Synthesis and design of macrocyclic collagen mimetic peptides for targeting the cancer-implicated DDR2 kinase
Project Summary / Abstract Collagen lays the foundation of bodily tissues, serving to strengthen, connect, and signal from the micro to the macro scale. The importance of collagen...
Contribution of Cellular and Molecular Heterogeneity of Esophageal Epithelium to Health Disparities in Esophageal Cancer
Project Summary Esophageal cancer is one of the most aggressive forms of human malignancy. Esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) are the pri...
Strategies for Personalizing Oxygen and support Therapies for dyspnea in Oncology
PROJECT SUMMARY Dyspnea is one of the most common and distressing symptoms associated with cancer, occurring in nearly 70% of patients with advanced cancer. Dyspnea is associated w...
Targeting the gut microbiome to inhibit melanoma lymph node metastases
PROJECT SUMMARY Melanoma is a devastating skin cancer that kills nearly 8,000 patients in the US annually. Patients with thicker melanomas, invading deeper and closer to lymphatics...
Development of novel CYP8B1 inhibitors
Project Summary Hepatocellular carcinoma (HCC) is a highly lethal cancer, and obesity is associated with an 89% increased risk of HCC. Because of the need for safer and more effect...
Dual Use Cessation: A MOST Screening Trial to Identify Effective Interventions to Help People Who Smoke and Vape
PROJECT SUMMARY Over the past decade, dual use of combustible cigarettes and electronic cigarettes (e-cigarettes) has risen substantially. The evidence is mixed as to whether this...
Ribonucleotide Processing in Telomere Maintenance and Integrity
Abstract Chromosomal ends harbor repetitive DNA sequences, termed telomeres, that are recognized by the shelterin complex to form a lariat structure called the T-loop, which protec...