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20,252 grants found
Showing 1,281 – 1,300 of 20,252 grants
Collagen Signaling in Pancreatic Cancer
Abstract Pancreatic Ductal Adenocarcinoma (PDA) is the 3rd most common cause of cancer death in the United States. One of the primary pathological features of PDA is the dense netw...
ID3 regulation of tissue-infiltrating T cells mediating graft-versus-host disease and leukemia rejection
PROJECT SUMMARY Graft-versus-host disease (GVHD) and the sequelae of immunosuppression have been a major barrier to the success of allogeneic hematopoietic stem cell transplantatio...
Dissecting and Targeting MAPK - PPARG Crosstalk in Bladder Cancer
Bladder cancer (BC) accounts for 80,000 new cancer diagnoses and 20,000 deaths annually in the US. Recent large-scale studies have comprehensively mapped the genetic landscape of B...
Deciphering the Impact of ZNF397-deficiency in Promoting TET2-driven Epigenetic Rewiring, Lineage Plasticity, and Therapy Resistance in Prostate Cancer
PROJECT SUMMARY Phenotypic plasticity and epigenetic reprogramming stand as two noteworthy cancer hallmarks. Lineage plasticity, in particular, has been recognized as a key mechani...
Image-guided Histotripsy System for Complete, Uniform, and Non-Invasive Ablation of Heterogeneous Osteosarcoma Tumors
Summary The goal of this project is to develop a novel histotripsy device for non-invasive treatment of heterogeneous osteosarcoma tumors (OS). OS are malignant bone tumors that de...
Therapy of PARP inhibitor-associated myeloid neoplasms in ovarian cancer patients
ABSTRACT Therapy-related myeloid neoplasms (tMNs), including myelodysplastic syndrome (MDS) and acute myeloid leuk- emia (AML), are severe, often rapidly fatal bone marrow disorder...
Clinical Neuroimmunology of CCL3 in Brain Tumors
ABSTRACT: Malignant primary brain tumors represent the most frequent cause of cancer death in children and young adults and account for more deaths than cancer of the kidney or mel...
Suppressing the Co-chaperone UNC45A reprograms the immunosuppressive tumor microenvironment to fight Cancer
Abstract Breast cancer remains one of the leading causes of death among women in the US. When available, targeted therapies have significantly improved the outcomes for breast canc...
Acceptance and Commitment Therapy for Patient Fatigue Interference and Caregiver Burden in Advanced Gastrointestinal Cancer
Project Summary/Abstract Fatigue interference with activities, mood, and cognition is one of the most prevalent and distressing concerns of advanced gastrointestinal cancer patient...
Structural Racism and Cardiovascular Outcomes Among Cancer Survivors
PROJECT SUMMARY/ABSTRACT Among individuals who survive ≥5-years from a cancer diagnosis, cardiovascular disease (CVD) is the leading cause of death. Black adults with cancer have t...
Cyanobacteria, cyanotoxins, and liver cancer development
Liver cancer remains a major challenge in the U.S. with over 41,000 new cases and 30,000 deaths annually. Hepatocellular carcinoma (HCC), the primary form of liver cancer, develops...
American Urological Association (AUA) Urologic Oncology Research Symposium on "Implementation Science: Translating Clinical Studies into Practice
2024 AUA OFFICE OF RESEARCH UROLOGIC ONCOLOGY RESEARCH SYMPOSIUM “Implementation Science: Translating Clinical Studies into Practice” PROJECT SUMMARY/ABSTRACT This application requ...
23rd Midwest DNA Repair Symposium
Abstract The 23rd Midwest DNA Repair Symposium (MDRS) will take place in Louisville, KY on June 1-2, 2024 at the Health Science Campus of the University of Louisville. The MDRS sta...
Metabolic flux analysis and PDX models to understand therapeutic vulnerabilities following inhibition of Ref-1 redox signaling in pancreatic cancer
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) exhibits an extraordinary resistance to therapy and often manifests as metastatic disease. It is characterized by hypoxia, a dense...
Supplement to Promote Diversity:Targeting p38/JNK MAPK to ameliorate cisplatin-induced adverse sequelae on the nervous system
No Changes to the Abstract Chemotherapy-related cognitive impairment (CRCI, chemobrain), chemotherapy-induced peripheral neuropathy (CIPN) and gait changes are debilitating side-ef...
Reducing Lung Cancer Risk among Appalachian Women Using Community‐Engaged Intervention Research
PROJECT SUMMARY Appalachian women are at high risk for lung cancer. Lung cancer is the leading cause of cancer-related death for women in the US, including the Appalachian region....
MATCHMAKERS: Large-scale generation of TCR-pMHC pairs from naturally occurring sources.
Abstract Understanding how T cell receptors (TCRs) see tumor antigens presented by MHCs is necessary to fully understand how the immune system recognizes tumor antigens, and to rea...
PROSPECT - Microbiome Studies. (PATHWAYS, RISK FACTORS, AND MOLECULES TO PREVENT EARLY-ONSET COLORECTAL TUMOURS)
ABSTRACT Our vision is to unravel and ultimately reverse the intricate network of causal factors throughout the life course that disrupts biological homeostasis to promote colorect...
MATCHMAKERS
Abstract Understanding how T cell receptors (TCRs) see tumor antigens presented by MHCs is necessary to fully understand how the immune system recognizes tumor antigens, and to rea...
PROTECT - Harnessing Protein Degradation for Advancing Childhood Tumors
ABSTRACT Background Survival rates for children with solid tumors, including brain, have largely plateaued over the past three decades making them the most common cause of disease-...