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20,252 grants found
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Mechanisms of treatment-free remission in a mouse model of chronic myeloid leukemia
PROJECT SUMMARY/ABSTRACT Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm diagnosed in about 5,000 Americans each year, characterized by the presence of the t(9;22)...
Machine-Learning Aided Design of Avidity-Based Biosensors of Ubiquitin Signaling
PROJECT SUMMARY This proposal is to develop a generalizable method to make genetically-encoded biosensors to monitor the dynamics, abundance, and positions of specific post-transla...
Targeting Metabolic Crosstalk in Pancreatic Cancer
Project Summary / Abstract Pancreatic ductal adenocarcinoma (PDA) is a devastating disease lacking effective treatment options. PDA is characterized by a dense and fibrotic tumor m...
Targeting HDAC11 to combat hepatocellular carcinoma and regulate alternative RNA splicing
PROJECT SUMMARY Liver cancer incidence and mortality continue to rise, and new therapeutic targets are needed. This fellowship application will explore how the enzyme histone deace...
Proteome-wide base editor screens to assess phosphorylation site functionality in immunosenescence
Abstract We often depict signaling pathways by a dozen or so landmark phosphorylation events that culminate in the transcription of a gene or induction of a phenotype. In reality,...
Engineering viral nanoparticles for TLR agonist-based multi-functional cancer immunotherapies
PROJECT SUMMARY/ABSTRACT Ovarian cancer is the most lethal gynecologic malignancy for women; standard of care surgery and chemotherapy treatment can provide a short period of remis...
Targeting Pancreatic Cancer Senescence with ImmunoPET
Project Summary Pancreatic cancer is the fourth-most lethal cancer across both sexes, with five-year overall survival of all stages at 12%. In patients diagnosed with pancreatic ca...
ACCESS-PC: Advancing Care Coordination to Enhance Shared Care for Complex Survivors in Primary Care
PROJECT SUMMARY/ABSTRACT Cancer survivors with cardiovascular disease risk factors (complex cancer survivors) are a growing population and their morbidity and mortality risks are s...
Computational tools for accurate inference of genetic ancestry from cancer-derived molecular data
Project summary/abstract For multiple cancer types, epidemiological data exhibit strong correlations between, on the one hand, the incidence of the disease, its severity when diagn...
Decoupling acute toxicities and antitumor efficacy in adoptive cell therapy
Project Summary Adoptive cell therapy (ACT) with chimeric antigen receptor (CAR) T cells has demonstrated impressive response rates in B cell malignancies, but ACT has not mediated...
The Regulation and Function of Small GTPases
Summary The 2024 FASEB SRC entitled “Regulation and Function of Small GTPases” represents the latest iteration of a long-standing conference on GTPase biology that first took place...
Deep learning-based target volume delineation capturing observer variability in head and neck cancer
We propose to develop and evaluate robust deep learning (DL)-based approaches capable of accurately delineating target volumes and predicting recurrence in head and neck cancer (HN...
2024 BTEC conference (5/14/24 to 5/17/24)
ABSTRACT/SUMMARY Brain tumors (malignant and benign/non-malignant) affect approximately 25 persons per 100,000 people in the United States annually. It is estimated that there were...
The regulation of gut macrophage’s function by the bile acid receptor FXR
Project Summary/Abstract: Colitis-associated colorectal cancer (CAC) is one of the most deadly types of colorectal cancer (CRC) that causes the most morbidity and mortality in pati...
Genetically engineered mouse models to investigate the liposarcoma microenvironment
PROJECT SUMMARY/ABSTRACT Liposarcoma (LPS) is the most common type of soft tissue sarcoma. The most common subtypes are well- differentiated (WDLPS) and dedifferentiated (DDLPS) li...
Ethnicity-driven pfeRNA in African American health disparities in lung cancer.
Project Summary: Non-small cell lung cancer (NSCLC) incidence and mortality rates are higher among African Americans (AA) than other racial or ethnic groups. A lower prevalence of...
Promotion of metastasis by apoptotic cells
Project Summary/Abstract The goal of most cancer treatments is to induce the apoptotic death of tumor cells; in many cases these treatments also induce substantial off-target apopt...
DNA Repair Deficiencies in Infertile Men and Cancer Risk
There is a need to identify the causes of the most severe form of male infertility, non-obstructive azoospermia (NOA), where there is spermatogenic failure resulting in an ejaculat...
Structure of the BRCA1-PALB2-BRCA2 complex
PROJECT SUMMARY The BRCA1, PALB2, and BRCA2 proteins form a heterocomplex that is involved in the maintenance of genomic stability, and variants of these proteins are implicated in...
A New Phase in ABI1 Biology: AR We Abl to Characterize the Intractable AR-DNA-ABI1 Axis?
PROJECT SUMMARY/ABSTRACT Intrinsically disordered proteins (IDPs) are a class of proteins that do not have a fixed three-dimensional structure. IDPs can be fully unstructured, or c...