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20,252 grants found
Showing 1,241 – 1,260 of 20,252 grants
Novel mechanism of chemokine nitration in bladder cancer
PROJECT SUMMARY The recent approval of immunotherapies has revolutionized the approach to managing bladder cancer (BCa). Nevertheless, complete response is observed in only a minor...
Development of Nanofunctionalized Cyborg C-Novyi NT for Image Guided Trans-arterial Bacteriolytic Embolization of Colorectal Liver Metastasis
PROJECT SUMMARY The long-term objective of this proposal is to improve the prognosis of patients with colorectal liver metastases (CRLM). Only 15% of these patients are candidates...
Genomics-based Mechanistic Investigation of Cancer-treatment Related Cardiotoxicity among Survivors of Childhood Cancer
ABSTRACT Childhood cancer survivors (CCS) experience early onset and a higher burden of cardiovascular disease (CVD) compared to community controls. Such health disparity is largel...
Epigenetic Programming of T Cells for Enhanced Cellular Immunotherapy
ABSTRACT By harnessing the power of the immune system to attack cancer cells, adoptive T cell therapy (ACT) holds tremendous potential to overcome the limitations of traditional ca...
Intrinsic and Extrinsic Factors Contributing to Trisomy 21 Preleukemia
PROJECT SUMMARY The initiating genetic alterations leading to blood malignancy occur as early as during fetal development. This is also true in children with Down syndrome (trisomy...
Children's Oncology Group Pediatric Early Phase Clinical Trial Network
PEP-CTN Project Summary/Abstract: The mission of the Pediatric Early Phase Clinical Trials Network (PEP-CTN) is to identify and develop effective new agents for children and adoles...
2024 Intrinsically Disordered Proteins Gordon Research Conference and Gordon Research Seminar
Project Summary/Abstract The 2022 Gordon Research Conference on Intrinsically Disordered Proteins “The Biophysics and Biology of Intrinsically Disordered Proteins” will be held Jun...
Development of small molecule therapeutics targeting AR-V7 for prostate cancer
Abstract Prostate cancer is the second most commonly diagnosed cancer in men in the U.S. About 250,00 cases and 34,000 deaths from prostate cancer occur each year, making it the le...
Development of small molecule therapeutics targeting AR-V7 for prostate cancer
Abstract Prostate cancer is the second most commonly diagnosed cancer in men in the U.S. About 250,00 cases and 34,000 deaths from prostate cancer occur each year, making it the le...
Biology and vulnerabilities of POU2F3+ tuft cell-like carcinomas
PROJECT SUMMARY Human cancers can be classified according to their cellular lineage, which is often defined by the presence of master regulator transcription factors. In several cl...
SMART" nanoparticle delivery of veratridine overcomes clinical challenges in metastatic colorectal cancer.
Project Summary Colorectal cancer (CRC) has a high mortality rate due to metastasis and drug resistance. CRC cells develop metastatic characteristics by hijacking different signali...
Defining the role of seed and soil in peritoneal metastasis evolution
The peritoneum is the third most common site of metastasis in colon cancer. Despite the common occurrence of peritoneal metastasis and its dire prognosis, very little is known abou...
Multilevel RCT of Rural Community Sun Safety for Young Children in Sports
PROJECT SUMMARY Melanoma is the deadliest form of skin cancer, disproportionately affecting rural areas of the US and driving up a disproportionate cancer burden. Children living i...
Aberration Correction for Histotripsy Ablation of Liver
Abstract Histotripsy is an ultrasound surgical technique for non-invasive ablation of tissue that uses very intense burstsof focused acoustic energy to mechanically fracture tissue...
Development of a 3D printed small animal intensity modulated radiation system
ABSTRACT Animal models are the backbone of many areas of biomedical and preclinical research and the mouse is the most used model organism in human disease research. Understanding...
Elucidate the Role of RNA Editing in Acute T-cell Lymphoblastic Leukemia Initiating Cells
SUMMARY/ABSTRACT Relapsed pediatric T-cell acute lymphoblastic leukemia (T-ALL) is often refractory to conventional therapy and is associated with a dismal survival rate of less th...
Investigating the role of metabolic rewiring in breast tumor innervation
PROJECT SUMMARY While primary, early-stage breast cancer is curable, metastatic breast cancer remains a clinically significant problem. Recent analyses of clinical samples have sho...
Defining impact of in situ activation of CD40 and type 1 interferon signaling on theTME and systemic T cell immunity in murine models and cancer patients
PROJECT SUMMARY Recent advances in cancer immunotherapies have revolutionized lung cancer treatment paradigms. However, many patients derive little or no benefit from FDA approved...
Mindfulness Meditation for Younger Breast Cancer Survivors: Testing Digital Interventions in Clinical and Community Settings
PROJECT SUMMARY Breast cancer is the most common cancer in younger women (≤ 50-years at time of diagnosis), who comprise approximately 19% of incident breast cancer cases. Improved...
The nuclear Ferredoxin reductase and its role in tumor suppression
Project Summary/Abstract We and others showed that ferredoxin reductase (FDXR), a mitochondrial flavoprotein, is induced by DNA damage in a p53-dependent manner and regulates apopt...