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20,252 grants found
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Training in Tumor Virology
Principal Investigator: Robertson, Erle S. Program summary Approximately 20% of all human cancers are associated with viruses that function as biological cofactors driving these ca...
Self-Testing for Cervical Cancer in Priority Populations: the STEP-2 Trial
PROJECT SUMMARY/ABSTRACT The 29.3 million patients receiving care in US Federally Qualified Health Centers (FQHCs) have much lower cervical cancer screening rates than national ave...
Utilizing nucleic acid scavengers to elucidate how DNA/RNA-containing DAMPs promote pancreatic cancer metastasis and to mitigate such processes
Statement of Work – Sullenger and White MPIs The overall objective of this project is to develop nucleic acid binding polymers that can scavenge extracellular nucleic acid-containi...
Noninvasive imaging and blood biomarkers for personalized lung cancer immunotherapy
ABSTRACT Lung cancer is the leading cause of cancer-related deaths in the United States and worldwide. Around ~80% of lung cancer is non-small cell lung cancer (NSCLC), and most pa...
Impact of bidirectional signaling between megakaryocytes and osteosarcoma cells on metastasis
PROJECT ABSTRACT: Osteosarcoma (OS) is the most common primary bone malignancy worldwide and primarily affects adolescents.While the 5-year survival rate is around 70% with localiz...
Structure and function of RAD51 paralog tumor suppressor complexes in genome maintenance
Project Summary RAD51-dependent homologous recombination (HR) is essential for faithful DNA double-strand break (DSB) repair and thus safeguards against genome rearrangements, neop...
A Molecular Approach to Dissecting MEK-Mediated Phosphorylation in Pediatric Leukemia
SUMMARY Acute lymphoblastic leukemia (ALL) is the most common hematological malignancy and the leading cause of cancer-related death in children in the United States. Multi-drug ch...
Discovery and Development of Natural Products for Interception of CRC
ABSTRACT Naturally occurring bioactive compounds are extensively studied as anticancer agents, particularly for therapeutic intervention. It is estimated that about 25% of all newl...
Discovery of novel natural TEAD inhibitors for the chemoprevention of liver tumors
PROJECT SUMMARY/ABSTRACT Hepatocellular carcinoma (HCC), the most common type of primary liver cancer, is a difficult disease to treat and a leading cause of cancer deaths worldwid...
Targeting the PNP - SAMHD1 synthetic-lethal combination in cancer
Abstract The enzymatic transition state structures of mammalian purine nucleoside phosphorylases (PNPs) were solved experimentally in this laboratory by a combination of intrinsic...
Investigating cancer-associated cachexia in genetic subtypes of lung cancer
PROJECT SUMMARY Cancer-associated cachexia (CAC) is characterized by the involuntary loss of skeletal muscle and adipose tissue mass. This multifactorial syndrome is driven by the...
PB-iCRC: Multi-site Practice-Based Implementation of a ColoRectal Cancer screening intervention
Project Summary/Abstract Although “implementation intentions”-based tools have been found to enhance colorectal cancer (CRC) screening uptake, prior studies have not tested to scal...
Examining the Impact of Structural Racism on African American Non-Small Cell Lung Cancer Mutational Signatures and Outcomes
ABSTRACT Non-Hispanic Black/African American (AA) individuals develop non-small cell lung cancer (NSCLC) 5-years earlier than their non-Hispanic White (NHW) counterparts. AAs also...
Breast cancer survivorship in the era of climate change: Impact of extreme weather, air pollution, and cancer therapy on heart and lung health
ABSTRACT Climate change is a global public health emergency that will increase cardiovascular (CV) and respiratory/pulmonary (R/P) morbidity and mortality as the population is expo...
BMT-CARE: Multimodal Psychosocial Intervention for Caregivers of Patients Undergoing Hematopoietic Stem Cell Transplantation
PROJECT SUMMARY/ABSTRACT Overview: The goal of this study is to demonstrate the efficacy of a cognitive-behaviorally based psychosocial intervention (BMT-CARE) compared to usual ca...
Men of African Ancestry are primed for aggressive prostate cancer by high prostate androgens driven by vitamin D deficiency and megalin
SUMMARY African American (AA) men have twice the risk of aggressive lethal prostate cancer (PCa) and are diagnosed younger than white men. Epidemiologic studies demonstrate an incr...
Investigating the role Ikaros variants in multiple myeloma pathophysiology and drug sensitivity
Investigating the role of Ikaros variant in multiple myeloma pathophysiology and drug sensitivity Multiple myeloma (MM) is a complex and heterogeneous disease in which malignant pl...
The Role of TGFβ2 and Macrophages in Cancer Cachexia
SUMMARY Cachexia is a significant contributor to increased mortality in various chronic diseases, including cancer. Patients with cancer cachexia experience unintentional body weig...
Molecular Dynamics of Glioma Formation and DNA Damage Response by Mutant IDH1
Project Summary/Abstract: Gliomas are the most common primary brain tumors in adults, a subset of which have mutations in the metabolic gene isocitrate dehydrogenase 1 (IDH1). Canc...
MAIT cells as a therapeutic approach for gastrointestinal cancers
Project Summary Colon cancer remains the 3rd most commonly diagnosed cancer and the 3rd highest cancer related mortalities in both men and women. Tumors are often resected, but the...