Browse All Grants
20,252 grants found
Showing 1,201 – 1,220 of 20,252 grants
Oncoprotein-regulated lineage plasticity in acute leukemia
Abstract Chromosomal translocations involving the Lysine Methyltransferase 2A (KMT2A) gene are commonly found in high-risk subtypes of acute leukemia and produce potent oncoprotein...
Aberrant Activation of Androgen Signaling Pathways in African American Prostate Cancer
Project Summary African American (AA) men have an increased risk for both prostate cancer (PCa) incidence and mortality. Although socio-economic status and other environmental and...
Randomized trial of REVITALIZE: A telehealth intervention to reduce fatigue interference among adults with advanced ovarian cancer on PARP inhibitors
ABSTRACT In the era of precision oncology, more patients are living longer with advanced cancer, yet many of the new strategies require years of fatiguing treatment. While cognitiv...
Par-4 Regulation of Actomyosin Contractility as a Tumor Suppressive Mechanism in Breast Cancer
Project Summary/Abstract Tumor progression – including resistance to therapy, metastasis, and recurrence – is responsible for the majority of cancer deaths. Understanding how cance...
Dissecting FOSL1-mediated lineage plasticity and resistance to androgen receptor signaling inhibition in prostate cancer
PROJECT SUMMARY/ABSTRACT CANDIDATE: I am a postdoctoral research associate in the laboratory of Dr. Yu Chen in the Human Oncology and Pathogenesis Program (HOPP) at Memorial Sloan...
MYC-alarmin axis as a novel therapeutic vulnerability in myelofibrosis
PROJECT SUMMARY Myelofibrosis (MF) is a hematologic malignancy that is characterized by constitutional symptoms, splenomegaly, bone marrow (BM) fibrosis, and high risk of transform...
Biomarkers For BRCA1-Deficient Cancers
ABSTRACT Each year an estimated 275,000 new cases of invasive breast cancer will be diagnosed in the US. Despite major advances being made to improve breast cancer treatment, the d...
Investigating luminal plasticity in prostate tumorigenesis
PROJECT SUMMARY The most common prostate disorders, benign prostate enlargement and prostate cancer (PCa), are associated with aging and attributed to hormonal imbalances and loss...
Investigating disseminated cancer cell clonal cooperation and immune control in dormancy and metastasis
SUMMARY. We revealed that cancer cells can disseminate from early stages of cancer progression and after variable periods of dormancy they go on to form metastasis. Knowledge about...
Developing ribosome biogenesis inhibitors for the prevention of cancer
SummaryTumor formation and cancer cell proliferation depend on enhanced ribosome biogenesis and protein synthesis. Ribosomes are the molecular machines responsible for protein prod...
Rapid, Single Cell Proteomic Profiling for Biomarker Development in Precision Oncology
PROJECT ABSTRACT Nearly two thirds of the 18 million new cancer patients each year fail treatment due to resistance that is not fully understood. Even in state-of-the-art clinical...
Rapid, Single Cell Proteomic Profiling for Biomarker Development in Precision Oncology
PROJECT ABSTRACT Nearly two thirds of the 18 million new cancer patients each year fail treatment due to resistance that is not fully understood. Even in state-of-the-art clinical...
Spatial stromal proteomic biosignatures of DCIS risk and progression
Ductal carcinoma in situ (DCIS) is a benign breast disease with the potential to develop into invasive breast cancer (IBC). DCIS is detected in around 25% of breast risk screens, y...
Sustaining antitumor effector CD8+ T cells for cancer therapy
Antitumor responses of CD8+ T cells are tightly regulated by distinct metabolic fitness. It has been reported that terminally differentiated exhausted T cells display impaired mito...
Analysis of galectin-8 and its ligands in melanoma progression
With successes in cancer treatment becoming more common, treating patients with metastatic melanoma (MM) is still grim. The advent of immune checkpoint inhibition (ICI) therapy, pa...
Targeting a PHGDH metabolic vulnerability in melanoma
SUMMARY While the last 15-years have brought remarkable clinical advances in melanoma therapy, the current standard- of-care targeted and immune therapies have hit a ‘ceiling’ that...
Genetic pleiotropy across pediatric cancers, and cancer-related outcomes
ABSTRACT More than 15,000 children are newly diagnosed with cancer each year in the US. Although breakthroughs in treatments have improved the survival rate to over 85%, cancer rem...
Population Health Management Approaches to Increase Lung Cancer Screening in Community Health Centers
Lung cancer is the leading cause of cancer-related mortality in the U.S., accounting for approximately 1 in 5 cancer-related deaths. Approximately 80% of lung cancers are attributa...
The impact of oxygen exposure on clinical biomarkers - an underrecognized source of pre-analytic variability
When preclinical research fails to replicate human biology, scientific progress stalls, clinical trials falter, and patients continue to suffer. While many factors contribute to th...
Novel radiomic signatures for treatment response to neoadjuvant therapy in rectal cancers
ABSTRACT: With nearly 45,000 rectal cancers to be diagnosed in 2023, the major clinical question of interest is the identification of those patients who will achieve sustained clin...