Browse All Grants
20,252 grants found
Showing 1,181 – 1,200 of 20,252 grants
Effects of the oral environment on KSHV shedding in Ugandan adults living with HIV
Project Summary/Abstract In sub-Saharan Africa (SSA), Kaposi’s sarcoma-associated herpesvirus (KSHV), the etiological agent of Kaposi’s sarcoma (KS), is endemic and HIV incidence i...
Identifying modifiable multi-level factors associated with HPV vaccine uptake in Kenya and Malawi
Project Summary/Abstract Cervical cancer burden falls disproportionately on women in low- and middle-income countries. Achieving cervical cancer elimination in these high-burden se...
Randomized controlled trial of varenicline to treat tobacco and cannabis co-use.
PROJECT SUMMARY/ABSTRACT The co-use of tobacco and cannabis is prevalent, appears to be increasing among adults in the United States (US), and has been shown to adversely affect tr...
Bhlhe40 Regulation of T Cell Function During Cancer Immunotherapy
PROJECT SUMMARY/ABSTRACT For cancer immunotherapies such as immune checkpoint therapy (ICT), success depends on sustained activation of intratumoral effector T cells recognizing tu...
Preventing Fatal Infections in Children with Down Syndrome During Treatment for Acute Lymphoblastic Leukemia
SUMMARY Children with Down syndrome (DS) have a 20-fold increased risk of developing acute lymphoblastic leukemia (ALL), a rate that is significantly higher than the general popula...
Next Generation T cell therapies for childhood cancers (NexTGen)
Next Generation T cell therapies for childhood cancers [NexTGen] Current treatments fail to cure many children with solid cancers.Recent advances in adult cancers such as checkpoin...
eDyNAmiC (extrachromosomal DNA in Cancer) - Understanding the biology of ecDNA generation and action, and developing new ways to target these mechanisms in cancer
Abstract: eDyNAmiC (extrachromosomal DNA in Cancer) Human genes are arranged on 23 pairs of chromosomes, but in cancer, tumour-promoting genes can free themselves from chromosomes...
Project 4 LUNG
ABSTRACT – FULL PROJECT 4 LUNG Lung cancer is a prominent source of cancer health disparity, particularly in Black men. While they have lower exposure to cigarette smoke, the most...
Protein kinase C and lung carcinogenesis
ABSTRACT Lung cancer is the leading cause of cancer-related deaths in the U.S., with ~236,700 new cases and ~130,200 deaths estimated for 2022. A joint effort by both PIs in this g...
A novel targeted antibody therapeutic to treat ovarian cancer
PROJECT SUMMARY Ovarian Cancer (OvCa) is the fifth leading cause of cancer deaths for women and is associated with very low survivability. Current treatment strategies for OvCa lar...
DEVELOPMENT OF A WEARABLE, NON-INVASIVE, TREATMENT DEVICE FOR METASTATIC TRIPLE-NEGATIVE BREAST CANCER (TNBC)
PROJECT SUMMARY/ABSTRACT Triple-negative breast cancer (TNBC) is a subtype of breast cancer that is highly invasive, has limited treatment options, and is prone to recurrence and m...
Metabolic reprogramming in Fanconi anemia-deficient head and neck squamous cell carcinoma
Project Summary/Abstract I am an MD/PhD student in the laboratory of Dr. Susanne Wells at Cincinnati Children’s Hospital Medical Center and the University of Cincinnati College of...
Harnessing low-field MRI and robotics to enable personalized incisionless prostate surgery
PROJECT SUMMARY/ABSTRACT Objective: The overarching goal of our research is to replace invasive radical prostatectomy with targeted, mini- mally invasive image-guided focal resecti...
Engineering RIG-I Activating Nanoparticles for Glioblastoma Immunotherapy
Glioblastoma (GBM) is a form of brain cancer with no cure and a five-year survival rate below 10%. Immunotherapies such as immune checkpoint blockade (ICB) have shown great promise...
Addressing the Training Gap in Oncology on Sexual Health: Development of the Sexual Health Integrative Fellowship Training (SHIFT) Course for Hematology-Oncology Fellows
PROJECT SUMMARY Over half of patients treated for cancer report concerns related to sexual health. If unaddressed, such concerns can cause substantial distress and compromise patie...
Quantitatively predicting drug-resistant mutations to improve precision oncology
PROJECT SUMMARY Quantitatively predicting drug-resistant mutations to improve precision oncology My work builds towards a mechanistically informed approach to model and predict dru...
Deciphering functions of the ATR-METTL3-BRCA1 Axis in genome instability and Tumorigenesis
PROJECT SUMMARY /ABSTRACT A defect in DNA damage repair triggers genome instability as a hallmark of cancer that is exploited by treatments such as ionizing radiation, platinum che...
HEME-Hospice: An Intervention to improve Hospice Use for Patients with Hematologic Malignancies
PROJECT SUMMARY Hospice is the gold standard of quality end-of-life (EOL) care. As compared to the de-facto option of dying in a hospital, hospice improves quality of life (QOL), r...
Radiomic spatial maps for identifying viable tumor extent on multi-parametric MRI for Glioblastoma
ABSTRACT: Glioblastoma (GBM) has a complex infiltrating tumor microenvironment which extends well beyond the visible enhancing tumor margins and plays a substantial role in GBM rec...
Clinical testing of Listeria-TT and Gemcitabine in a Phase I clinical trial with PDAC patients
ABSTRACT The overall objective of this STTR Fast-Track project is to prepare and perform a Phase I clinical trial in metastatic unresectable pancreatic ductal cancer adenocarcinoma...