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20,252 grants found
Showing 101 – 120 of 20,252 grants
Accelerating Behavioral and Social Sciences through Ontology Development and Application: NIH Research Network Project (APRICOT).
Title: Advancing Prevention Research In Cancer through Ontology Tools (The APRICOT project) Abstract Progress in behavioral research in cancer prevention is hampered by imprecision...
Comprehensive Molecular and Clinical Characterization of Acute and Chronic Neurotoxicity Following CAR-T Cell Therapy
PROJECT SUMMARY Chimeric antigen receptor (CAR) T-cell therapy has transformed the treatment of hematologic malignancies, resulting in remarkable disease response rates. Yet, the u...
Using a Pragmatic Randomized Rollout Trial to Evaluate Implementation Strategies to Promote Smoking Treatment and Cancer Prevention for Salvation Army Clients
ABSTRACT / PROJECT SUMMARY The prevalence of combustible cigarette tobacco use remains high among socioeconomically disadvantaged Americans despite declines in the broader populati...
SCH: Visual explanation-guided learning for human-AI collaborative abdominal cancer diagnostic imaging
PROJECT SUMMARY (See instructions): Early detection of abdominal cancers is notoriously challenging. Symptoms are often unclear, and tumors are located deep inside the body, making...
Identification of BAIAP2 and CDC42 as potential therapeutic targets in SHH medulloblastoma
PROJECT SUMMARY/ABSTRACT The most common malignant pediatric brain tumor is medulloblastoma. Despite advancements in treatment, medulloblastoma survivors have significant long-term...
Nurses Surviving Breast Cancer: An exploration of breast cancer diagnosis, reported lymphedema symptoms, and lifestyle status in the Nurses' Health Study Survey
Project Summary/Abstract Breast cancer-related lymphedema (BCRL) is a side-effect of anticancer treatment. Caused by damage to the lymphatic system secondary to surgery, chemothera...
Planning to implement high-quality active surveillance in new-onset favorable risk prostate cancer
Project Summary Many men with favorable-risk prostate cancer do not benefit from aggressive intervention. As a preferred alternative, active surveillance is increasingly used to sp...
SESAME: Sun Exposure and Activities after Skin CAncer: Optimization of Mhealth IntErventions
ABSTRACT There are currently 1.36 million melanoma survivors in the US, and this number is expected to increase to 1.92 million by 2030. Most melanoma patients (92%) survive 5 or m...
Support for bereaved friend and family caregivers of cancer patients
Bereaved friend and family caregivers have taken on the burden of end-of-life care for patients with cancer who die in hospice care at home. Bereavement can be emotionally devastat...
An allogeneic gamma/delta armored Dual-Targeting CAR with Split Costimulatory Domains to Target Epithelial Ovarian Carcinoma
Abstract CAR T cell therapies have produced robust remissions in several hematological malignancies. However, they have not achieved the same success against solid tumors. These tr...
Aging-related hematopoietic stem cell intrinsic and microenvironmental signals in AML transformation
Summary Acute myeloid leukemia (AML) is a disease of the elderly that often transforms from pre-AML states of age- related clonal hematopoiesis (ARCH), myelodysplastic syndromes (M...
Core A: Administrative Core
The objective of Core A is to supervise and facilitate overall progress of the scientific work of the Program. Specifically, scientific management is combined in this Core with adm...
Project 1: Role of emergency myelopoiesis as a driver of clonal evolution in AML
PROJECT DESCRIPTION Our overall goals are to establish (i) whether the hijacking of emergency myelopoiesis (EM) pathways represents a shared mechanism of leukemogenesis in the cont...
Project 2: Microenvironmental and inflammatory mechanisms in MDM4-driven AML pathogenesis.
Project Summary/Abstract Recent studies have demonstrated the existence of preleukemic (preL) HSPC (which includes the phenomenon of age-related clonal hematopoiesis (ARCH)) in hum...
Project 3: Role of stromal cell-activated CNOT6L deadenylase in driving AML transformation
Role of stromal cell-activated CNOT6L deadenylase in driving AML transformation. AML has long been thought to be exclusively driven by genetic or epigenetic mutations within HSCs....
Core B: Computational Genomics Core
Core B: Computational Genomics Core. Core Director: Raul Rabadan The Computational Genomics Core will provide a centralized structure to collect, analyzed and integrate data from a...
Point of Care Detection and Diagnosis of Oral Cancer using a Low Cost Imaging Module enabled by AI
PROJECT SUMMARY/ABSTRACT The overall vision of the proposed project is to to develop and deploy an affordable automated point-of-care (POC) telecytology platform for oral cancer sc...
BLOOD-BASED PROTEOMIC ASSAY FOR PANCREATIC CANCER DETECTION
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease that is usually asymptomatic at an early stage. In addition, metastases can be present even when the cancer size is rela...
Planning grant for Take Off Pounds Sensibly (TOPS) for African American (AA) Cancer Survivors
1. Abstract Our long-term goal is to decrease the weight-related breast cancer and cardiovascular disease mortality among African American breast cancer survivors. In the R01 appli...
Dissecting Molecular Mechanisms of Tumor-Induced Myeloid-Mediated Immune Suppression in Triple-Negative Breast Cancer
PROJECT SUMMARY Breast cancer remains the leading cause of cancer-related mortality in women worldwide. Despite considerable progress in the treatment of early-stage disease, a sig...