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20,252 grants found
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Exploring synthetic lethality with a novel very high energy electron FLASH radiation beam
ABSTRACT: Radiation therapy is a necessary component of current treatment for many brain tumors. Radiation therapy leverages a therapeutic ratio in which tumor cells suffer radiati...
Nanoparticle-coated macrophages for targeted disruption of YAP/TEAD interactions in breast cancer brain metastasis
Project Summary Brain metastasis is prevalent among patients with metastatic breast cancer. Brain metastasis can emerge as multi-focal, inoperable, and radiation-resistant lesions...
A Multiplatform Approach to Develop ENL-Targeting Molecules as Drug Candidates for Acute Myeloid Leukemia
PROJECT SUMMARY/ABSTRACT Acute myeloid leukemia (AML), a blood and bone marrow malignancy, manifests as an aggressive disease that requires immediate treatment. A key player in AML...
3D genome reorganization drives cancer development
PROJECT SUMMARY/ABSTRACT The three-dimensional (3D) genome folding organization within the nucleus of cells plays a key role in epigenomic regulation in both normal physiology and...
VCP in ASPSCR1::TFE3-driven oncogenic transcription reprogramming
Project Abstract ASPSCR1::TFE3 (AT3) is a fusion oncoprotein transcription factor expressed from the junction site of a t(X;17) chromosomal translocation that defines alveolar soft...
Novel mechanisms of B cell tumorigenesis and relapse
Abstract: B cell malignancies comprise more than 50% of blood cancers, approximately 85% of lymphomas, and all myelomas. Despite recent treatment advancements that significantly pr...
Direct targeting of HIF1a-driven transcription in TNBC with engineered STRs
Project Summary: Tumor cells are exposed to a wide array of stressors ranging from hyperactive protein synthesis and metabolism to nutrient and oxygen starvation in the tumor micro...
Enhancing CAR-T cell therapy through theranostic targeted radionuclide therapy
PROJECT SUMMARY Chimeric antigen receptor (CAR)-T cell therapy has emerged as a powerful new class of living medicines for cancer therapy, especially for patients with resistant or...
Identifying Chemo-Neoepitopes for Immunotherapy Interventions Against Triple-Negative Breast Cancer
PROJECT SUMMARY/ABSTRACT Patients with advanced triple-negative breast cancer (TNBC) have a poor prognosis, with a median overall survival of ~18 months with standard-of-care (SOC)...
Inhibition of pleiotrophin to combat pancreatic cancer metastasis
Project Summary Pancreatic ductal adenocarcinoma (PDA) is projected to become the second leading cause of cancer-related deaths in the United States by the year 2030 unless signifi...
Nautral products for targeting Skp2 in cancer interception
Project Summary Prostate cancer (PCa) is the second most common cancer in American men and is responsible for 3% of total deaths and 10% of deaths by cancer. Most patients experien...
Development of a theragnostic radiopharmaceutical for pancreatic cancer
Abstract Pancreatic adenocarcinoma (PDAC) is the third leading cause of cancer mortality, reflecting the fact that only 9% of patients present with tumor localized to the primary s...
Biologic and Functional Characterization of In Vivo CAR-T cells
Project Summary Chimeric Antigen Receptor (CAR) T cell therapy has revolutionized treatment for B cell malignancies by targeting T cytotoxicity to the site of the tumor. Despite th...
Defining the transition from deep quiescence to senescence
PROJECT SUMMARY Cell-cycle exit can be either transient (quiescence) or permanent (senescence), and these different states are thought to have distinct molecular characteristics. F...
Therapeutic value and mechanistic action of PSPC1 in AML
Summary Acute myeloid leukemia (AML) is a biologically and genetically heterogeneous hematopoietic malignancy characterized by the blockage of myeloid cell differentiation and unco...
Stress, inflammation, and health-related quality of life of long-term breast cancer survivors
A breast cancer (BC) diagnosis is a significant life event that can adversely impact health-related quality of life (HRQOL) in BC survivors by inducing major stress associated with...
Nuclear Bodies: Hubs of Genomic Activity
Project Summary/Abstract This application seeks support for a FASEB (Federation of American Societies of Experimental Biology) Science Research Conference, entitled: “Nuclear Bodie...
Real time scattered x-ray imaging for tumor motion tracking in radiotherapy.
PROJECT SUMMARY Stereotactic Body Radiotherapy (SBRT) has been established as an effective, safe, and feasible first-line option in lung cancer. The quest for dose escalation to in...
Mechanisms and Therapy of Radiation Resistance in Breast Cancer
Summary: The goal of this revised proposal is to develop a novel therapeutic approach for overcoming resistance to radiation therapy in triple negative breast cancer (TNBC) and to...
Development of Deep Mutational Scanning with Duplex Sequencing (DMS-DS) for anti-cancer drug evaluation and administration
Cancer remains a leading cause of death worldwide. Targeted agents have dramatically improved the prognosis of over 30 cancer types, but are fundamentally limited by the evolution...