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20,252 grants found
Showing 1,141 – 1,160 of 20,252 grants
RNA oxidation in RAS-driven cancer
ABSTRACT Chemical modifications in RNA play a crucial role in regulating gene expression in physiological and pathological conditions. One underexplored aspect of this regulation c...
Salmonella as a vector for delivery of oncolytic viruses to hepatocellular carcinoma
Summary The goal of the proposed research is to develop a bacterial vector to deliver oncolytic viruses (OVs). As immunotherapies, OVs regress many cancers and have had clinical su...
Characterization of drug mechanisms of lethality in vivo
PROJECT SUMMARY/ABSTRACT Understanding mechanisms of drug action is important for identifying settings in which a drug will be effective, and for interpreting – even predicting – p...
ABL kinase inhibition sensitizes SCLC to dysregulation of metabolic pathways leading to cell death
ABSTRACT Prognosis for patients with small cell lung cancer (SCLC) remains poor due to high rates of metastatic disease, vast intra-tumoral heterogeneity, limited therapeutic optio...
Extending experimental evolutionary game theory in cancer in vivo to enable clinical translation: integrating spatio-temporal dynamics using mathematical modeling
ABSTRACT Targeted cancer therapy, in the form of tyrosine kinase inhibitors, has been a game changer for patients with cancers driven by activating mutations in genes encoding thes...
Optimization and validation of a biomarker panel for risk stratification in Barrett's esophagus
Project Summary: Intestinalization of the esophagus, termed Barrett’s esophagus (BE), is thought to develop in response to chronic acid and bile reflux and carries great clinical s...
Biomaterial Scaffolds for In Vivo CAR T Cell Manufacture
PROJECT SUMMARY CAR-T cell therapy has revolutionized the treatment of liquid tumors, including leukemia and lymphoma, and hold enormous promise for treatment of solid cancers as w...
CANCAN - Spatially resolved metabolic measurements in cells and organs during cancer cachexia
Cancer cachexia is a multifaceted syndrome characterized by significant loss of body weight and muscle mass, which is not reversible through conventional nutritional support. This...
NexTGen - DFCI
No Abstract
NextGen - CARDIFF
Next Generation T cell therapies for childhood cancers [NexTGen]Current treatments fail to cure many children with solid cancers. Recent advances in adult cancers such as checkpoin...
eDyNAmiC - CAMBRIDGE
eDyNAmiC (extrachromosomal DNA in Cancer)Human genes are arranged on 23 pairs of chromosomes, but in cancer, tumour-promoting genes can free themselves from chromosomes and relocat...
NexTGen - STANFORD
Next Generation T cell therapies for childhood cancers [NexTGen]Current treatments fail to cure many children with solid cancers. Recent advances in adult cancers such as checkpoin...
NGTC - INSERM
Next Generation T cell therapies for childhood cancers [NexTGen]Current treatments fail to cure many children with solid cancers. Recent advances in adult cancers such as checkpoin...
NGTC - UCL
Next Generation T cell therapies for childhood cancers [NexTGen]Current treatments fail to cure many children with solid cancers. Recent advances in adult cancers such as checkpoin...
Supplement: Lentiviral-Induced Swine Model of Spinal Cord Glioma - Tumor Microenvironment in IDH-Mutations Low-Grade Glioma
PROJECT SUMMARY This application is being submitted in response to Notice of Special Interest (NOSI) identified as NOT-CA-24-029. High-grade Spinal Cord Glioma (SCG) is an orphan d...
eDyNAmiC-QMUL
eDyNAmiC (extrachromosomal DNA in Cancer)Human genes are arranged on 23 pairs of chromosomes, but in cancer, tumour-promoting genes can free themselves from chromosomes and relocat...
NextGen - CHOP
Next Generation T cell therapies for childhood cancers [NexTGen]Current treatments fail to cure many children with solid cancers. Recent advances in adult cancers such as checkpoin...
Project 3: Targeting MYC in CRC
PROJECT SUMMARY/ABSTRACT: P3. Targeting MYC Recurring genetic perturbations in colorectal cancer (CRC) activate MYC, an oncogenic transcription factor that features prominently in...
The immunoPeptidoGenomic (iPepGen) informatics resource forimmuno-oncology research
SUMMARY Immuno-oncology studies continue to grow which seek new therapies leveraging immunogenic, non-normal peptide sequences (neoantigens) arising from tumor-specific alterations...
Phage-based therapeutic gene delivery targeting multiple compartments in solid tumors
ABSTRACT Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that accounts for approximately 10-20% of all breast carcinomas and is often associated with...