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20,252 grants found
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Exploring the role and potential of anti-viral drugs to sensitize cancer cells to chemotherapy
PROJECT SUMMARY Chemotherapy remains the most used systemic treatment for cancers. However, despite significant improvement in chemotherapy agents, chemoresistance remains the majo...
Genomic and functional approaches to characterize Chr1q gains in cancer
Abstract Chromosome gains and losses are found in nearly all human cancers. However, the functional importance of these massive gene dosage imbalances remains poorly understood. No...
Extending experimental evolutionary game theory in cancer in vivo to enable clinical translation: integrating spatio-temporal dynamics using mathematical modeling
ABSTRACT Targeted cancer therapy, in the form of tyrosine kinase inhibitors, has been a game changer for patients with cancers driven by activating mutations in genes encoding thes...
The genetics of tumor suppression by p53 - Diversity Supplement
Project Summary This is a request for a supplement to R01 CA279585 to train Ms. Andrea Valdespino, a highly talented graduate student from the University of Pennsylvania to train w...
Functional Characterization and Development of Therapeutic Paradigms for DNA Damage Repair (DDR)-deficient Lethal Prostate Cancer
PROJECT SUMMARY/ABSTRACT The overarching scientific premise of our parent grant is to thoroughly investigate the impact of BRCA2 and DNA damage repair (DDR) gene alterations on the...
CaRE2 NCI Diversity Supplement
Contact PD/PI: WILKIE, DIANA J SUMMARY – OVERALL COMPONENT The Florida-California Cancer Research, Education & Engagement (CaRE2) Health Equity is proposed by the University of...
m6A-suite: an informatics pipeline and resource for elucidating roles of m6A epitranscriptome in cancer
Project Summary N6-methyl-adenosine (m6A) is the most abundant mRNA methylation in mammalian cells. Emerging evidence has linked m6A with cancer phenotypes in many cancers, spurrin...
Enhanced Viro-Immunotherapy for Breast Cancer Brain Metastasis
PROJECT SUMMARY/ABSTRACT Breast cancer brain metastasis (BCBM) is a major clinical challenge due to their poor response to therapeutic options. Although the survival rate of breast...
Pilot in vivo trial with T-cell-based delivery of immunostimulatory proteins
PROJECT SUMMARY In this project, the investigators will explore the feasibility of using their cell-based platform for delivering immunostimulatory proteins (IS) to achieve tumor r...
Mechanistic Study of Methotrexate-Induced Oxidative Distress in Neurons and the CSF
PROJECT SUMMARY The neurocognitive side effects of cancer chemotherapy in pediatric patients are heart-breaking; not only must these children deal with the hardship of the disease...
Discovery of a stem cell driving breast cancer spine metastases
Project Summary For breast cancer, skeletal metastases are a major source of the pain, disability and mortality associated with disease progression. As with other solid tumors meta...
Immunogenetic determinants of cancer risk
PROJECT SUMMARY It has been shown that variation in cancer risk is influenced by mutations that may be inherited, caused by environmental factors such as smoking and ultraviolet ex...
Neoadjuvant Immunotherapy Platform Study Reveals Mechanisms of Response in Hepatocellular Carcinoma (HCC)
PROJECT ABSTRACT Hepatocellular carcinoma (HCC) is a significant global health problem and is expected to become the third leading cause of cancer mortality in the United States (U...
An engineered bacterial reporter gene fusion for radiotheranostics
Project Abstract The most important unmet need in oncology is to overcome the lack of effective therapy for advanced solid tumors in adults and children. Despite major advances in...
isomiRGate: a comprehensive gateway for studying the canonical and modified microRNAomes in Cancer
PROJECT SUMMARY According to the statistics provided by the American Cancer Society, in 2023, about 1.9 million new cancer cases will be diagnosed in the United States, and more th...
Role of the inflammatory dietary pattern in gut and colon tissue microbiomes and impact on survival outcomes among colorectal cancer patients
Colorectal cancer (CRC) is the 3rd most commonly diagnosed cancer and 3rd leading cause of cancer-related deaths in the United States. Poor dietary quality and the gut microbiome a...
Enabling a rapid transition from synthase to structure
Project Summary. Polyketide natural products have played, and will continue to play, critical roles in cancer chemotherapy. Though they are potent and often tumor-selective agents,...
Using patient-derived co-culture models of breast cancer to develop new treatment strategies targeting succinate signaling.
PROJECT SUMMARY/ABSTRACT: This proposal addresses the lack of patient-derived model systems in hormone receptor positive (HR+) breast cancer, and also the lack of ethnically repres...
Estrogen Suppression as a Strategy to Enhance Immunotherapy Efficacy in EGFR-Mutated Non-Small Cell Lung Cancer
PROJECT SUMMARY Non-small cell lung cancer (NSCLC) among never-smokers is on the rise. Mutations in the epidermal growth factor receptor (EGFR) gene are common and found in >50%...
Leveraging cancer-evolved resistance mechanisms to enhance EZH2 activity in adoptive T cells
Abstract The clinical landscape of metastatic melanoma has been revolutionized by immune checkpoint blockade (ICB); however, despite these advancements, the effectiveness of ICB fo...