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20,252 grants found
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Core 2: Mouse and Human Molecular Imaging
PROJECT SUMMARY/ABSTRACT: Mouse and Human Molecular Imaging Core The Mouse and Human Molecular Imaging (MHMI) Core will play a central role in the translational research mission of...
Core 3: Biostatistics and Bioinformatics
PROJECT SUMMARY/ABSTRACT: Biostatistics and Bioinformatics Core The purpose of the Biostatistics and Bioinformatics Core (BBC) is to provide professional expertise in biostatistics...
Project 1: Interrogating Distinct Tumor-Initiating Cells in CRC
PROJECT SUMMARY/ABSTRACT: P1. Interrogating Distinct Tumor-Initiating Cells A major therapeutic barrier in advanced colorectal cancer (CRC) is tumor recurrence after treatment. The...
Project 2: Targeting Glutamine Metabolism to Enhance EGFR Blockade in Wild-Type RAS CRC
PROJECT SUMMARY/ABSTRACT: P2. Targeting Glutamine Metabolism to Enhance EGFR Blockade in WT RAS CRC Colorectal cancer (CRC) is the second leading cause of cancer-related death in t...
Computational tumor phenotyping to interrogate treatment resistance and immune dysregulation in head and neck cancer
ABSTRACT: Head and neck squamous cell carcinoma (HNSCC) is the 7th most prevalent cancer globally, resulting in 930,000 new cases and 467,000 deaths annually. Alongside tobacco and...
A vascularized microphysiological system (MPS) platform for modeling peritoneal carcinomatosis
PROJECT SUMMARY Peritoneal carcinomatosis (PC) is the deadliest form of colorectal cancer (CRC) and gastric cancer (GC) metastasis, with a median survival of 10-18 months for CRC a...
A compass for those with relapsed leukemia after transplant
ABSTRACT Relapse of leukemia occurs in nearly half of patients after hematopoietic cell transplantation (HCT). While there are a growing number of therapeutic options for leukemic...
Innovating CBT-I for Cancer Survivors: An Optimization Trial
30-50% of cancer survivors who have completed treatment with curative intent have untreated insomnia. Cancer survivors from diverse racial and ethnic backgrounds experience a highe...
Improving anti-tumor immunity in advanced breast cancer by targeting solid stress
Project Summary Response rates to current immunotherapies are comparably low in breast cancer patients, yet patients with T cell infiltrates often respond better. To improve the re...
Sexual Health and Rehabilitation (SHARE): An Online Educational Intervention for Young Adult Female Cancer Survivors
Project Summary Sexual dysfunction is one of the most common and distressing consequences of cancer therapy for young female (YF) cancer survivors, with more than 50% of YF survivo...
Using microvolumetric cyst fluid proteolysis for early detection of pancreatic cancer
ABSTRACT Pancreatic cystic lesions (PCLs) are the only radiographically identifiable precursor to deadly pancreatic carcinoma and they are detected in a million people annually in...
Novel gene delivery to modulate the tumor microenvironment and antigen-specific antitumor immunity
Abstract Technological advancements have yielded novel drug targets and improved cancer detection, but transformative innovations in treatment modalities are lacking. Leveraging ou...
Functional Relevance of Pyrimidine Sensing and Response Pathways in Tumor Metabolism and Cancer Therapy
Nucleotide metabolism is effectively targeted by anti-cancer agents, but their use is limited by toxicity to non- transformed cells, especially anti-cancer immune cells. Our overar...
Alpha-Emitter Therapy of Osteosarcoma
ALPHA- EMITTER THERAPY OF OSTEOSARCOMA PROJECT SUMMARY Three-year overall survival for patients with recurrent osteosarcoma (OS) is 20%. Current therapy for metastatic osteosarcoma...
Macrocycle inhibition of beta-catenin mediated transcription in prostate cancer
Project Summary Among men, prostate cancer is the most prevalent form of cancer and the third most common cause of cancer- related death. While patients with localized disease have...
Novel Tracheostoma Device
ABSTRACT Surgical removal of the larynx profoundly affects a patient’s quality of life, particularly in the loss of normal vocalization, physical change in appearance, and emotiona...
Pressure-Enhanced Sensing Surgery (PRESS) as a tool for surgical guidance.
ABSTRACT Some surgery procedures can be made more specific through the use of administered tracers that enhance the contrast through digital imaging of the field at the time, as do...
Integrated Genomic-Transcriptomic Characterization to Identify Molecular Mechanisms of Disparities in PDAC Outcomes
Abstract Despite advances in diagnostic and therapeutic modalities, the 5-year survival of patients with pancreatic adenocarcinoma (PDAC) remains woefully low. Unfortunately, Afric...
On-Demand Modulation of Extracellular Matrix Mechanics for Studying RhoA Activation in Primary and Metastatic Colorectal Cancer
PROJECT SUMMARY Despite innovations in diagnosis and treatment, colorectal cancer (CRC) remains one the most common causes of cancer-related deaths in the United States. During tum...
Dissecting Tumor-Immune Interactions in HIV-HPV Co-Infection-Associated Oropharyngeal Cancer using Single Cell Sequencing and Novel Mouse Models
Project Summary/Abstract Oropharyngeal squamous cell carcinoma (OPSCC) has emerged as a significant global health concern, with increasing incidence attributed to human papillomavi...