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20,252 grants found
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Development of Novel Heterogeneous Range Modulators for FLASH Particle Therapy
FLASH radiotherapy utilizing ultra-high dose rate has the potential of being a substantial evolutionary advancement for cancer treatment. Ultra-high dose rate radiation provides a...
The role of HPF1 in radiation and genotoxic cancer therapy
PROJECT SUMMARY/ABSTRACT Cancer radiation therapy generates reactive oxygen species (ROS), which cause both single and double-strand DNA breaks that rapidly recruit and activate Po...
Addressing racial disparities in colorectal cancer risk prediction
PROJECT SUMMARY With Black men and women experiencing a disproportionately high burden of colorectal cancer (CRC), there is a critical need for new improved risk prediction tools t...
Multi-organ metastatic breast cancer cell-based assay platform that models organotropic metastases using patient organoids in human tissue-derived ECMs to accelerate anti-metastatic drug development
PROJECT ABSTRACT Xylyx is developing a predictive multi-organ metastatic breast cancer cell-based assay platform to address the lack of in-vitro models of organotropic metastatic b...
Quantifying patient-provider communication using machine learning to assess its impact on metastatic cancer patients' outcomes
About two million persons are diagnosed with cancer every year in the US. The Effective clinical management of cancer patients including the use of oral therapies can improve outco...
Targeting DYRK2 to eradicate leukemia stem cells in chronic myeloid leukemia.
Project Summary Chronic myeloid leukemia (CML) is an aggressive hematological malignancy caused by the oncoprotein BCRABL1. Although tyrosine kinase inhibitors (TKIs) can help CML...
Mechanism by which ketogenic diet uncouples tumor growth and overall survival
The overarching goal of this proposal is to add to the understanding of the complex interaction between the tumor and the host organism to facilitate new therapeutic approaches in...
Antibody-based prertargeted alpha particle therapy for ovarian cancer
Project Summary High-grade serous ovarian carcinomas (HGSOC) account for 75% of ovarian cancer diagnoses, and about 80% of patients have metastatic disease upon diagnosis. Metastat...
Stromal Effects in Head and Neck Squamous Cell Carcinoma
Squamous cell carcinoma of the head and neck (HNSCC) is a complex disorder that contains multiple cell populations, making it is difficult to study the nature and cellular function...
Preventing Melanoma Metastasis by Targeting Lipid Vulnerabilities in Lymph
ABSTRACT Although most melanoma deaths are caused by distant metastasis, the mechanisms that regulate metastasis are poorly understood. During metastasis, cancer cells encounter ox...
Targeting retrotransposons for improved treatment of refractory childhood cancer
Despite notable improvements in childhood cancer survival rates, patients with relapsed or refractory disease face grim prospects, and childhood cancer remains the commonest cause...
Deciphering the Mechanism of Lymphovascular Space Invasion Using a Lymphovascularized Bioengineering Breast Stromal Platform
Highly aggressive cancers are frequently characterized by tumor cell emboli within the lymphatic and blood vasculature. Termed lymphovascular space invasion (LVSI), this phenomenon...
A novel engineered IL-21-based immunocytokine as a therapeutic approach for tumor targeting in renal cancer
PROJECT SUMMARY/ABSTRACT Renal cell cancer (RCC) is a lethal disease whose incidence is on the rise. Clear cell renal cell cancer (ccRCC), the most aggressive and the deadliest var...
Development and validation of an autologous mouse model for the study of immune interactions with glioblastoma
Project Summary An adaptive immunosuppressive microenvironment is a major barrier to immune-based therapies for solid tumors, including glioblastoma (GBM). Current model systems fo...
Investigation of Immunotherapy-induced Alterations to Cellular Communication Networks in Pancreatic Ductal Adenocarcinoma
PROJECT SUMMARYPancreatic ductal adenocarcinoma (PDAC) is one of the deadliest forms of cancer in the United States. The low mutationalburden in PDAC leads to low infiltration of T...
MOSAIC: Administrative Core
SUMMARY: ADMINISTRATIVE CORE The overarching objective for the Mayo/Columbia MOSAIC CSBC is to build a conceptual framework to understand tissue state transitions that happen in gl...
The CANcer Cachexia Action Network (CANCAN): a Multidisciplinary Virtual Institute with the Mission to Cure Cancer Cachexia
Abstract Background Cancer cachexia (CC) is a systemic, metabolic wasting syndrome featuring body weight loss due to skeletal muscle and adipose tissue wasting. CC is suffered by ~...
Vanderbilt-Ingram Cancer Center SPORE in Gastrointestinal Cancer
PROJECT SUMMARY/ABSTRACT This is a Supplement requesting interim funds to support the Vanderbilt-Ingram Cancer Center GI SPORE, which continues to focus on colorectal cancer, the s...
Administrative Core
PROJECT SUMMARY/ABSTRACT: Administrative Core The Vanderbilt-Ingram Cancer Center SPORE in Gastrointestinal (GI) Cancer Administrative Core will support all GI SPORE cancer-related...
Core 1: Tissue Pathology and Cellular Analysis
Project Summary/Abstract: Tissue Pathology and Cellular Analysis Core The Translational Pathology and Cellular Analysis (TPCA) Core, will play a central role in the translational r...