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20,252 grants found
Showing 1,061 – 1,080 of 20,252 grants
Identification of Covalent Transcriptional Dependencies in Melanoma
PROJECT SUMMARY/ABSTRACT Advances in human genetics have identified 400+ genes that when amplified or mutated promote tumorigenesis. While there has been substantial success in dev...
Interoception and Obesogenic Eating Behaviors in Children
PROJECT SUMMARY/ABSTRACT Obesity is a key risk factor for several types of cancer. Development of healthy weight and eating behaviors during childhood has the potential to reduce c...
Controlling Tumor Immune Escape in Pancreatic Cancer using a Dual T Cell Product Strategy
ABSTRACT While T cell therapies have shown efficacy in hematologic malignancies, extension of this success to solid tumors has proven to be challenging, mainly due to the immunosup...
The Role of Early Life Exposure to Antibiotics on Risk of Early Onset Colorectal Cancer
PROJECT SUMMARY/ABSTRACT The incidence of early onset colorectal cancer (EOCRC) has increased in the past four decades and is predicted to increase by 140% by 2030.4,5 It is the se...
Engineered biomimetic collective cancer invasion models for screening chemotherapeutic agents
PROJECT SUMMARY Metastasis is the primary cause of cancer mortality, yet few breast cancer drugs effectively inhibit metastasis. Breast cancer cells use collective migration to rem...
Targeting microbial triggers of gammopathy for immunoprevention
Abstract: Multiple myeloma (MM) is an incurable plasma cell tumor preceded by a defined preneoplastic state termed as monoclonal gammopathy of undetermined significance (MGUS). Str...
Efficacy Trial of Healthy Juntos: A Family-based Digital Lifestyle Intervention for Hispanic Adolescents and their Parents
PROJECT SUMMARY Obesity, physical inactivity, and poor diet are major modifiable risk factors for cancer — a leading cause of death among US Hispanics. US Hispanic youth have the h...
Lung fibrosis impairs tumor immunity and limits immune checkpoint efficacy
PROJECT SUMMARY/ABSTRACT The long-term goal of this proposal is to train the applicant to become an independent, academic physician- scientist studying immune responses against lun...
Gordon Research Conference (GRC) on Signaling by Adhesion Receptors
The Gordon Research Conference (GRC) on Signaling by Adhesion Receptors was established in 2000 and has become the premier meeting on cellular adhesion biology, mechanobiology, and...
Development of a Novel Immunotherapeutic for Acute Myeloid Leukemia
Acute Myeloid Leukemia (AML) and the Need for Advanced Treatment: AML is a prevalent hematological malignancy in adults, with a 5-year survival rate of only 32%. While approximatel...
The Role of Propionate Metabolism in Non-Small Cell Lung Cancer
Project Summary/Abstract Despite exciting advances, lung cancer remains the leading cause of cancer-related deaths in the United States. A critical gap in our understanding is how...
TOXICOLOGY STUDIES IN MICE AND DOGS ADMINISTERED MTX-531
The purpose of this work is to perform toxicology studies in rats and dogs in order to prepare compound MTX-531 for IND submission.
Developing a Values Elicitation Tool to Improve Treatment Decision-Making in Acute Myeloid Leukemia
PROJECT SUMMARY/ABSTRACT This NCI K08 Mentored Career Development Award will prepare Dr. Daniel Richardson to become an independent R01-level investigator in patient-centered cance...
Personalized Risk-based Follow-up of Cervical Cancer Screening in Practice (PREDICT)
Abstract Cervical cancer is highly preventable when detected early and managed appropriately; today it is most often diagnosed in under-screened individuals or after a failure to f...
Combined Imaging and RNA Analyses to Develop Cervical Cancer Biomarkers
TITLE: Combined Imaging and RNA Analyses to Develop Cervical Cancer Biomarkers ABSTRACT Despite significant advances in disease prevention and screening, cervical cancer continues...
Determinants of toxicity and response to immune checkpoint blockade through integrative profiling of T cell clonal dynamics and plasma cell- free DNA
PROJECT SUMMARY Severe immune-related adverse events (irAEs) occur in up to ~60% of melanoma patients treated with combination (anti-PD1 / anti-CTLA4) immune checkpoint inhibitors...
SPOT-IT: Sepsis Prediction in Oncology Through Implementation Science and Technology
Project Abstract Patients with cancer face unacceptable morbidity and mortality from sepsis, a life-threatening dysregulated response to infection. Oncologic sepsis contributes to...
A parallelized computational microscope platform for high-throughput live imaging of patient-derived organoids
Significance: As a biologically relevant miniaturized model system for human tissues, 3D organoids offer a powerful new platform for high-throughput biomedical research, including...
Leveraging a community-academic partnership to pilot a family-centered communication intervention for Latinx young adult childhood cancer survivors
PROJECT SUMMARY Adult survivors of childhood cancer face a lifetime of health risks due to past cancer treatments, with an estimated 80% experiencing at least one severe or life-th...
Targeting cell state transitions driving resistance to KRAS inhibitors in lung cancer
Lung adenocarcinoma (LUAD), commonly driven by KRAS mutations, is responsible for 7% of all cancer mortality. LUAD predominantly arises from alveolar type 2 (AT2) cells, which func...