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20,252 grants found
Showing 1,021 – 1,040 of 20,252 grants
Defective urea cycle promotes oncogenesis of hepatocellular carcinoma
PROJECT SUMMARY In mammals, majority of nitrogen waste is produced by gut microbiome in the form of ammonia. Ammonia is a neurotoxin and is cleared by two major pathways: 1) conver...
Development of a Tunable Protein Release Hydrogel for the Enhancement of CAR T cell Activity
Project Summary and Abstract Chimeric antigen receptor (CAR) T cells are genetically engineered T lymphocytes designed to sense antigens and mount an immune response. Though CAR T...
IPP - DRUG DEVELOPMENT SUPPORT FOR CTEP
The “Drug Development Support for the CTEP” contract provides support to the Cancer Therapy Evaluation Program (CTEP) Regulatory Affairs Branch (RAB) and Investigational Drug Branc...
A Fragment-Based Strategy for K-RAS Covalent Inhibitors
ABSTRACT KRAS is the most frequently mutated oncogene with mutation rates of 95% in pancreatic ductal adenocarcinoma (PDAC), 45% in colorectal cancer, and 30% in lung adenocarcinom...
Prebiotic effect of eicosapentaenoic acid treatment for colorectal cancer livermetastasis
PROJECT SUMMARY / ABSTRACT Colorectal cancer (CRC) is the second leading cause of cancer death in the U.S. Approximately 30-50% of CRC patients develop liver metastasis (CRCLM), a...
Project 4: Neoadjuvant Clinical Trial with Pembrolizumab for Locally Advanaced Squamous Cell Carcinoma (SCC)
This is a phase II single-arm neoadjuvant pembrolizumab trial in patients with PD-1 naïve resectable locally advanced SCC.
Discovery of MAP2K7 Inhibitors Through DNA-Encoded Chemical Screens to Treat T-Cell Acute Lymphoblastic Leukemia
Project Summary Acute lymphoblastic leukemia (ALL) is an aggressive hematological malignancy. The disease incidence peaks in children younger than five, declining until the mid-20s...
Targeted nanotherapies for the treatment of prostate cancer
Project Summary The proposed project addresses the critical need for the treatment of advanced prostate cancer (PCa), a second leading cause of cancer-related deaths among men in t...
Understanding and overcoming resistance of breast cancer brain metastases to RET inhibition
Project Abstract Breast cancer brain metastasis (BCBM) is associated with poor prognoses and dismal survival of 4-6 months following diagnosis. Management of BCBM remains a major c...
Defining features of the neoantigen-specific T cell response against a common EGFR mutation in lung cancer
PROJECT SUMMARY/ABSTRACT Driver mutations confer increased fitness to cancer cells but can also encode neoantigens that stimulate an anti- cancer immune response. This anti-tumor i...
Non-coding RNA regulation of Myeloid Cells
PROJECT SUMMARY Tumor-Associated immune Macrophages (TAMs) are a metabolically and functionally heterogeneous population of cells that play critical roles in both anti-tumor immuni...
Effects of Provider Integration on the Diagnostic Evaluation of Breast Complaints in Medicare Patients
Project Summary The cancer care delivery system frequently provides care that is not patient-centered, evidence-based, or accessible to vulnerable and underserved populations. Canc...
Peripheral Nerve Regulation of Pancreas Cancer Progression
Abstract Pancreatic cancer is the third leading cause of cancer deaths in the United States and most patients are refractory to currently available therapies. However, we have obse...
Alveolar Responses to Airway Injury
Project Summary Lung disease is one of the leading causes of death in the world today, with chronic obstructive pulmonary disease (COPD) being the third leading cause of mortality...
Deleted in malignant brain tumors 1 (DMBT1) expression and impact on colonic dysplasia
PROJECT SUMMARY/ABSTRACT Bacteria-host interactions are emerging as critically important mechanisms for cancer progression but are poorly defined in precancerous colonic dysplasia....
Identification of novel biomarkers and therapeutic strategies in chemobrain.
PROJECT SUMMARY While current treatment approaches can cure most children diagnosed with cancer, chemotherapy-induced cognitive impairment (CICI) has emerged as a significant medic...
Causes and Consequences of Adenosine Signaling in Pancreatic Cancer
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive forms of cancer, known for its profound immune suppression and resistance to most therapies. O...
Epstein-Barr Virus/Kaposi Sarcoma Associated Herpesvirus 2024 Meeting
ABSTRACT This conference grant application requests funds to help support the 2024 International Conference on EBV & KSHV. The conference will be held at the Boston Park Plaza...
Combinatorial application of nanoscale technologies to target a novel mechanism of immune evasion by cancer cells
PROJECT SUMMARY Immunotherapy holds the promise of a cure for cancer. However, only a subset (
Predictive and Diagnostic Radiomic Signatures in Non-Small Cell Lung Cancer (NSCLC)on Immunotherapy
PROJECT SUMMARY We propose to identify novel radiomic signatures of anti-programmed death ligand 1 (PDL1)/PD1 therapy response for non-small cell lung cancer (NSCLC) and evaluate h...