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20,252 grants found
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Unveiling how the molecular landscape of TNBC sculps intratumoral macrophage origin and function
ABSTRACT/PROJECT SUMMARY. Triple-negative breast cancer (TNBC) is a heterogenous set of diseases and is considered one of the most aggressive breast cancer subtypes. TNBC lack of w...
Characterizing and Overcoming MHC-I-Mediated Immune Evasion in Triple-Negative Breast Cancer
PROJECT SUMMARY Breast cancer is estimated to be the most diagnosed cancer in American women and account for 15% of female cancer-related deaths in 2023. Triple-negative breast can...
Mechanistic examination and inhibitor targeting of nutrient scavenging for the treatment of pancreatic cancer
Project Summary Abstract Alteration of essential metabolic pathways is a major mechanism by which oncogenic KRAS promotes tumor development and growth in pancreatic ductal adenocar...
Testing ATAD2 as a new therapeutic target for advanced prostate cancer
PROJECT SUMMARY/ABSTRACT Prostate cancer is the second leading cause of male cancer death. Advanced prostate cancer, whether present at the time of diagnosis or arising after treat...
Investigating the Role of Diet and ACSS2 in Metabolic and Epigenetic Regulation of Colorectal Cancer
PROJECT SUMMARY/ABSTRACT Colorectal cancer (CRC) is a leading cause of cancer mortality and is significantly affected by multifactorial influences including host genetic and epigen...
The crosstalk between obesity-induced fatty liver and liver metastasis
PROJECT SUMMARY/ABSTRACT CANDIDATE: As a postdoctoral fellow in Dr. Scott Lowe’s lab at MSKCC, my research focuses on the contribution of obesity-induced non-alcoholic fatty liver...
Integrating Electronic Patient-Reported Outcomes into Discharge Planning
PROJECT SUMMARY A prolonged hospital stay after cancer surgery is a common but potentially avoidable problem that negatively impacts quality of care. Goal-directed pathways for dis...
Role of Th2 cytokines in progenitor-mediated formation of tumor lymphatics
PROJECT SUMMARY/ABSTRACT Role of Th2 cytokines in progenitor-mediated formation of tumor lymphatics Lymph node metastasis, a common event in breast cancer, is a strong indicator of...
A novel cellular identity regulatory pathway that drives anokis resistance-mediated TNBC growth and metastasis
Women in the United States have a 1 in 8 PROJECT SUMMARY lifetime risk of developing breast cancer. Among the various breast cancer subtypes, triple-negative breast cancer (TNBC) c...
Defining the Mechanistic Basis of Bacterial Androgen Production in Dampening Anti-Tumor Immunity and Promoting Resistance to Androgen Receptor Axis-Targeted Therapies for Metastatic Prostate Cancer
Project Summary/Abstract There is increasing evidence over the past decade that the composition of the gut microbiome is important for cancer therapy effectiveness including chemot...
Promoting Effective Clinical Communication about Sexual Health after Gynecologic Cancer: A Randomized Controlled Trial of a Patient-Focused Intervention
PROJECT SUMMARY Sexual problems are common, distressing and persistent for patients with gynecologic cancer (GC). Yet most patients with GC who experience sexual concerns do not ra...
Learning features of optimal CAR T cells for LBCL from patient data
PROJECT SUMMARY/ABSTRACT Chimeric antigen receptor (CAR) T cells have emerged as breakthrough treatments for patients with hematologic malignancies, earning 12 approvals from the U...
Understanding mechanisms of impaired immunity in the AML bone marrow
PROJECT SUMMARY/ABSTRACT Immune-based treatments for acute myeloid leukemia (AML), an aggressive hematologic malignancy that remains fatal for over half of the 20,000 patients diag...
Decoding the Molecular Basis of Dysregulated Cleavage and Polyadenylation in Myeloid Malignancies - Resubmission - 1
PROJECT SUMMARY This proposal aims to investigate dysregulation of alternative polyadenylation (APA) in acute myeloid leukemia (AML). Dysregulation of APA has been identified in he...
Multi-cohort validation of machine learning radiogenomic models (ML-RGx) to predict late toxicity in prostate cancer
PROJECT SUMMARY Radiotherapy is a cornerstone of treatment for prostate cancer, but radiation-related genitourinary (GU) and gastrointestinal (GI) toxicities can negatively impact...
Multi-parametric Perfusion MRI for Therapy Response Assessment in Brain Cancer
The long-term goal of this program is to improve patient care by optimizing and validating quantitative magnetic resonance imaging methods for the early prediction of brain cancer...
Base editing to elucidate RAF regulation and signaling
Project Summary Mitogen activated protein kinase (MAPK) signaling regulates cell growth in normal cells and is frequently overactivated in cancer. Within this pathway, RAF kinases...
Targeting mTORC1 translational control in FOXO1 fusion positive rhabdomyosarcoma
PROJECT SUMMARY PAX3-FOXO1 and related fusions create oncogenic transcription factors that remodel chromatin to drive a subset of childhood rhabdomyosarcoma (RMS) with dismal cure...
PIK3C2A is a vulnerable immunotherapeutic target in triple-negative breast cancer combination therapy
PROJECT SUMMARY Treatment options for triple-negative breast cancer (TNBC) have been very limited. However, specific molecular features such as high PD-L1 expression, elevated tumo...
Immunosuppressive impact of the GPCR/MALT1 protease axis in triple-negative breast cancer
PROJECT SUMMARY/ABSTRACT Breast cancer is the most common cancer in women. Triple-negative breast cancer (TNBC) lacks expression of estrogen receptor (ER-), progesterone receptor (...