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20,252 grants found
Showing 961 – 980 of 20,252 grants
Dissecting the Functional Consequences of Mutations in ZFP36L2 on Tumor Progression and Inflammation in the Tumor Immune Microenvironment of Colorectal Cancer
PROJECT SUMMARY/ABSTRACT Colorectal cancer (CRC) is a devastating disease with no effective therapeutic options for patients suffering from advanced metastasis. Immune checkpoint i...
ProAgio in Pancreatic Cancer
SUMMARY/ABSTRACT Cancer associated fibroblasts and pancreatic stellate cells (PSC/CAF) and abnormal tumor blood vessels are two major factors that contribute to treatment failure....
Understanding the role of altered lipid metabolism in CD8 T cell exhaustion within the tumor microenvironment
PROJECT SUMMARY/ABSTRACT The recent successes of checkpoint blockade therapies have highlighted the potential of immunotherapy for cancer treatment. Still, only about 30% of treatm...
Endothelial Cell Cycle Control to Normalize the Tumor Vasculature
Tumor blood vessels are dysfunctional and irregular, impairing immune cell infiltration and drug delivery and creating areas of severe hypoxia that select for aggressive cancer cel...
Enhanced radiotherapy for pediatric glioma via synthetic lethal vulnerabilities
Project Summary Diffuse midline gliomas (DMG) are the most common malignant brain tumors of children. They are surgically inaccessible and refractive to chemotherapy. The prevalent...
Exploring the molecular mechanisms controlling CDK7i sensitivity in pancreas cancer
PROJECT SUMMARY/ABSTRACT Pancreatic ductal adenocarcinoma (PDA) is projected to be the second leading cause of cancer deaths in the US by 2030. With no cost-effective screening or...
IL-6 and IL-6R genetic polymorphisms in immune-related adverse events caused by cancer immunotherapy
SUMMARY The achievements obtained with different types of cancer immunotherapy are clear, with durable long-term survival in some cases. The most frequently used immunotherapeutic...
Structural and mechanistic investigation into EWS::FLI1 disruption of EWS function in transcription and DNA repair
PROJECT SUMMARY Ewing sarcoma is a pediatric bone and soft tissue cancer that results from chromosomal translocation, most commonly t(11;22)(q24;q12), which fuses the low-complexit...
Dissecting the Role of TRPV1 in Triple-Negative Breast Cancer Innervation
PROJECT SUMMARY: Breast cancer is the most common form of malignancy in women, accounting for almost one in three new female cancer diagnoses each year. The primary cause of breast...
Brain microenviornment-dependent lineage plasticity drives adaptation to targeted therapy in malignant gliomas
PROJECT SUMMARY/ABSTRACT Malignant gliomas are the most common primary adult brain cancer, affecting over 20,000 Americans each year. While molecularly targeted therapies have demo...
Targeting tumoral Lactobacillus iners to improve outcomes in cervical cancers
Cervical cancer remains the second most common cancer killer of women worldwide, with an annual incidence of more than 600,000 and an annual death rate of 300,000. Further, cervica...
Identifying cell surface targets for innovative immunotherapy of Multiple Myeloma
Project Summary Multiple myeloma (MM) is an incurable malignancy of mature plasma cells accounting for 1.8% of new cancer cases annually, and 10% of hematological malignancies. Imm...
Development of a New Multiplexed Imaging Strategy for Immunoprofiling using Raman-Active Nanoparticles
Project Summary The -omics era has made it possible to identify several molecular markers involved in predicting survival and response to therapies. We currently lack an easy way t...
Elucidating Glutamine Metabolism in Breast to Bone Metastasis
Project Summary Several aggressive types of breast cancer (BCa) are nutritionally reliant on glutamine metabolism, and glutamine uptake has been shown to be enhanced in BCa bone-ho...
Defining Tumor Microenvironmental Mediators of Prostate Cancer Metastasis and Therapy Resistance
Metastatic prostate cancer remains incurable and inevitably progresses to lethal disease despite expanding treatment options.Standard of care includes therapies targeting the andro...
Engineering CD4+ T cells to develop a novel immunotherapy for pancreatic cancer
Project Summary: Pancreatic ductal adenocarcinoma (PDAC) is a solid tumor with limited treatment options and a dismal five-year survival rate of only 12%, necessitating the develop...
Development and characterization of self-amplifying RNA Lipid Nanoparticles for potent and multiplex gene expression in solid tumors
Project Summary Specific Aims Solid tumors account for nearly 90% of adult cancers and are challenging to eliminate. Surgery and adjuvant therapy (e.g., radiation, chemotherapy, an...
Engineering Focused Ultrasound-Mediated Gene Delivery Platforms for Glioblastoma
Abstract Glioblastoma multiforme (GBM) is an aggressive primary brain tumor with a median survival of approximately 15 months. Currently, the standard of care therapy includes rese...
THE FUNCTION OF CASPASE-8 IN CANCER, ANTI-CANCER IMMUNITY, AND CAR-T CELL FUNCTION
Project Summary/Abstract: Caspase-8 is the primary protein that drives the extrinsic apoptotic pathway, and is frequently mutated, contains polymorphisms, or downregulated in vario...
Dynamics and Encoding in Signal Transduction
PROJECT SUMMARY Cell communication research is a growing field that is complimentary to, but distinct from, traditional signal trans- duction fields. This emerging field emphasizes...