Browse All Grants
20,252 grants found
Showing 941 – 960 of 20,252 grants
Quantitative MRI to automatically delineate intraprostatic tumor for radiation therapy
PROJECT SUMMARY Prostate cancer (PCa) is the most common cancer among men. Radiation therapy is an integral part of the standard of care for the treatment of PCa. Local recurrences...
Discovery of Potent Selective Inhibitors of the Histone Methyltransferase SUV39H1 for the Treatment of Cancer
PROJECT SUMMARY Cancer treatment has been transformed by a class of drugs, that includes Keytruda and Opdivo, that enables the immune system to recognize and selectively kill cance...
Novel estrogen receptor mutations as a biomarker dictating therapy response in advanced endocrine-resistant estrogen receptor-positive breast cancer
PROJECT SUMMARY While there have been tremendous advances in the treatment of estrogen receptor-positive (ER+) breast cancer, late-stage ER+ metastatic breast cancer (MBC) has very...
Develop a PET radiotracer suitable for in vivo imaging of TGFβ
Project Summary/Abstract Transcription growth factor beta (TGFβ) is a pleiotropic cytokine with a significant role in creating an immunosuppressive tumor microenvironment. High lev...
Targeting HMGA1 Tumor-Stromal Networks in Pancreatic Carcinogenesis
HMGA1 Chromatin Regulators in Pancreatic Carcinogenesis ABSTRACT Background: We propose to elucidate mechanisms mediated by High Mobility Group A1 (HMGA1) chromatin regulators in p...
PROSPECT: Premalignant Oral Lesions Pathology and Epigenetic Risk Prediction Tool
ABSTRACTThis application validates a minimally invasive, multi-stage artificial intelligence (AI)-based cytologic, histologic andepigenetic biomarker to identify oral premalignant...
Targeting Tregs in the solid tumor microenvironment by modulating metabolite signaling
ABSTRACT The efficacy of cell-based immunotherapies in treating solid tumors is hampered due to challenges pertaining to infiltration, function, and persistence of CD8+ effector T...
The Role of Mechanical Stress in Mitigating Side Effects of Chemotherapy
First line platinum-based chemotherapies kill cancer cells through formation of bulky DNA adducts, however,these adducts also form in healthy tissues leading to side effects that s...
Enhanced Pain Coping in Cancer (EPIC)
PROJECT SUMMARY/ABSTRACT Chronic pain is a common symptom that affects 30-40% of cancer survivors, diminishing their quality of life, impairing physical functions, and increasing h...
Intraoperative quantitative CT imaging of breast specimen for reducing re-surgery rate and tumor cataloguing
Project Summary/Abstract The objective of the project is to develop the world-first X-ray dual-energy cone-beam microCT (DECB µCT) dedicated to intraoperative imaging of lumpectomy...
A novel pathway to overcome resistance to immunotherapy in melanoma
Project Summary/Abstract Despite the progress in the treatment of advanced melanoma brought by the approval and use of immune checkpoint inhibitors (ICIs), most patients are resist...
Partnering with primary care to address goals of equity, value and sustainment for primary cancer prevention
PROJECT SUMMARY/ABSTRACT Rural-serving primary care clinics in our Colorado Implementation Science Center in Cancer Control (COISC3) seek to address inequities in behavioral cancer...
Targeting cytoplasmic SET oncoprotein by sphingolipid analog drugs for the induction of necroptosis to treat lung cancer
SUMMARY Non-small cell lung cancer (NSCLC) remains the deadliest cancer, and novel therapeutic strategies are needed to improve treatment outcomes of patients with this disease. FT...
Allosteric mechanisms driving paradoxical activation of RAF kinases
ABSTRACT Mutations in the BRAF protein kinase are key drivers of melanoma, thyroid cancer, and colon cancer. Existing drugs, like vemurafenib, that target the most common BRAF muta...
Mechanisms of JAG1-mediated immune suppression in the pancreatic cancer microenvironment
Pancreatic cancer (PanCan) is notorious for its resistance to therapy including immunotherapy, which is largely contributed by a suppressive tumor microenvironment. Targeting molec...
Epigenetic drivers of lung metastasis in osteosarcoma
PROJECT SUMMARY Osteosarcoma (OS) metastasis is the leading driver of mortality, but there are no therapies tailored to metastatic disease. Despite the development of numerous trea...
Generating hiPSC-derived ATRT models to investigate cell of origin and identify therapeutic vulnerabilities
Project Summary Atypical teratoid rhabdoid tumors (ATRTs) are aggressive pediatric brain cancers that lack standardized treatment regimens. After radiotherapy treatments, survivors...
The frequency and function of Type 3 Innate Lymphoid Cells regulates the melanoma tumor microenvironment
Project Summary/Abstract Malignant tumors escape immune surveillance by evading, suppressing, or distorting immune function. The recent success of immune checkpoint blockade therap...
Development of novel nanotherapeutics to overcome therapy resistance using canine brain tumor as a spontaneous model
Title: Development of novel nanotherapeutics to overcome therapy resistance using canine brain tumor as a spontaneous model Project Summary/Abstract High-grade gliomas (HGGs), incl...
Dissecting the role of the Fanconi anemia pathway in chromothripsis
PROJECT SUMMARY/ABSTRACT Cancer-associated chromosomal abnormalities frequently arise through punctuated episodes of genomic instability. This is exemplified by chromothripsis, the...