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20,252 grants found
Showing 921 – 940 of 20,252 grants
Uncovering the Molecular Determinants of Metastatic Recurrence and Impaired NK Cell Function
PROJECT SUMMARY Our proposed research employs innovative, unbiased approaches and novel preclinical models to elucidate how disseminated HER2+ breast cancer cells cells survive in...
Targeting Senescence and the senescent secretome to impact breast cancer formation
Project Summary Senescence and the senescence associated secretory phenotype (SASP) have long been implicated in driving tumorigenesis. However, the pro-tumorigenic mechanism(s) of...
Optimizing Theranostic Dosimetry and Kidney Biomarkers for Alpha-Emitter Radioligand Therapy in Neuroendocrine Tumors
SUMMARY The somatostatin subtype 2 receptor (SSTR2) is expressed in 80-100% of NETs. SSTR2 targeted alpha-emitter radioligand therapy (α-RLT) is emerging as an exciting alternative...
A translational study of a synthetic lethality interaction of CD105 and androgen receptor signaling axis for castration-resistant prostate cancer patients
The goal of this proposal is to better understand a novel signaling axis initiated in prostate cancer (PCa) patients by next-generation androgen receptor signaling inhibitors (ARSI...
Understanding mechanisms of BTK inhibitor and degrader resistance in patients with chronic lymphocytic leukemia
Project Summary Covalent inhibitors of Bruton’s tyrosine kinase (BTK) are effective in multiple B-cell malignancies but patients discontinue these agents due to resistance and into...
Multispectral imaging of bile duct epithelial morphology for early detection of malignancy
Project Summary Bile duct cancer, also known as cholangiocarcinoma, is the second most common primary liver cancer. It is considered to be an incurable cancer with no identifiable...
Genetically-engineered Bacteria Overcome Therapy Resistance
Project Summary: For this proposal in response to PAR-22-085: Microbial-based Cancer Imaging and Therapy - Bugs as Drugs, we will focus on metastatic pancreatic ductal adenocarcino...
Targeting metabolic stress response to improve CAR-T cell efficacy.
Project Summary T cell-based immune therapies are a promising approach to treat cancer. Chimeric antigen receptor (CAR) is one such therapy developed by engineering a protein compr...
Reducing toxicity from prostate cancer radiotherapy through genetics and technology
PROJECT SUMMARY/ABSTRACT There is an incredible need to find new biomarkers to improve our ability to personalize cancer therapy, to identify those that will have toxicity from tre...
Unravel the novel role of S100A7 and its functional partners in Metastatic Triple Negative Breast Cancer Racial Disparity
Triple-negative breast cancer (TNBC) disproportionately affects African American (AA) women, with mortality rates 65% higher than Caucasian (CA) women. The mechanisms underlying th...
Frontiers in Bone Metastatic Models for Prostate Cancer
PROJECT SUMMARY/ABSTRACT Metastasis is responsible for more than 90% of prostate cancer-related mortality and remains a considerable challenge in developing effective and durable t...
A generalizable model of normal tissue recovery to enable personalized re-irradiation
Our current clinical approach to re-irradiation is not based on data. Guidelines vary widely and are not rooted in observed toxicities. A frequently cited reason for that is both t...
Combination optical imaging to guide transoral laser microsurgery in larynx cancer
PROJECT SUMMARY Nearly 13,000 new cases of laryngeal cancer are diagnosed in the U.S. annually. Transoral laser microsurgery (TLM) has become the primary surgical approach for earl...
A study of IDH1-mutant prostate cancer to identify novel therapeutic targets
Abstract While over 90% of patients with metastatic prostate cancer respond to systemic therapies that block androgen receptor signaling, nearly all of these patients will eventual...
Molecular mechanisms of allele-specific NRAS signaling and tumorigenesis
ABSTRACT Cancer-associated RAS mutants were once considered oncogenic equivalents. However, it is increasingly clear that mutants of the same RAS isoform (H-, K- or NRAS) and amino...
Role of Grail in colon inflammation and tumorigenesis
PROJECT SUMMARY/ABSTRACT Chronic intestinal inflammation is a major risk factor for the development of colorectal cancer (CRC). It is well- acknowledged that pro-inflammatory cytok...
Investigating KIF20A as a therapeutic target in glioblastoma
Project Summary/Abstract Elevated expression of KIF20A, a mitotic kinesin required to promote cytokinesis, the final step of cell division, is a near-universal feature of human can...
Tumor-Activated Dual Payload-Drug Conjugates
PROJECT SUMMARY/ABSTRACT Targeting the hallmark biomarker prostate specific membrane antigen (PSMA) has been a successful small molecule drug-delivery strategy for various payloads...
Epigenetic re-establishment of tumor suppression in glioblastoma
PROJECT SUMMARY This project focuses on a new epigenetic vulnerability of human glioblastoma (GBM), the most common and deadly adult primary brain malignancy. We discovered the bro...
Understanding lung cancer genomics in patients of African ancestry
PROJECT SUMMARY Lung cancer is the leading cause of cancer death among the African American population. Although many actionable biomarkers and targeted treatments are available to...