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20,252 grants found
Showing 901 – 920 of 20,252 grants
Cancer Genomics: Integrative and Scalable Solutions in R/Bioconductor
Abstract Bioconductor is a crucial resource for statistical analysis and data management in cancer genomics research, providing more than 2,200 open-source software and data packag...
Targeted delivery of a VEGF‐blocking scFv by CD70 CAR‐T cells to enhance anti‐tumor activity in renal cell carcinoma
PROJECT SUMMARY Although chimeric antigen receptor (CAR)-T cells drive dramatic and durable remissions in patients with B-cell malignancies, responses in solid tumors have been mor...
Optimizing treatment decisions and quality-adjusted life years through improved lung cancer staging
PROJECT SUMMARY The number of patients with potentially curable, stage I-III non-small cell lung cancer (NSCLC) is increasing, and appropriate treatment selection depends upon the...
Structure-guided cancer immunotherapy design with HLA-Arena and CrossDome
Project Summary The broader use of T-cell-based therapies is still hindered by challenges related to the identification of peptide- targets that are both immunogenic (capable of act...
Dissecting the role of germline genetic variation and viral exposures as determinants of hematological disease predisposition
ABSTRACT The role of germline genetic variation and viral infection in development and progression has been studied extensively in adult tumors and autoimmune disease. Less attenti...
TGF-β Superfamily Conference: Signaling in Development and Disease
Abstract The FASEB SRC TGF-β Superfamily: Signaling in Development and Disease Conference in 2024 (hereafter “TGF-β 2024”) will bring together investigators who are leaders in a va...
Addressing financial hardship in adolescent and young adult cancer survivors: Efficacy and implementation of a multilevel intervention in community-based oncology practices
Project Summary Adolescent and young adult cancer survivors (AYAs; ages 15-39-years) are an important underserved group at risk for significant financial hardship. There are nearly...
2024 Radionuclide Theranostics for the Management of Cancer Gordon Research Conference and Gordon Research Seminar
Project Summary/Abstract The Gordon Research Conference (GRC) and Symposium (GRS) for "Radionuclide Theranostics for the Management of Cancer", a rapidly emerging field i...
Innovations in diagnosis for lymphadenopathy across HIV Centers of Excellence in Malawi
ABSTRACT In SSA, deaths occur in 5-10% of PLWH during the first year after initiating antiretroviral therapy (ART) and causes for these early deaths are not well elucidated in most...
Microsphere-based formulation of dolcanatide to prevent colon carcinogenesis
Abstract Colorectal cancer (CRC) ranks third among newly diagnosed cancers in the United States, and it is the second most common cause of cancer mortality. Individuals with inflam...
Synthetic Biology for Splice Modulating Polyketides
Project Summary. Natural product-derived RNA splice modulators are being developed for the treatment of acute myeloid leukemia as well as other cancers. As natural products with co...
Immunoassay for Measuring Mutation Activated Kinases Across Multiple Cell Signaling Pathways
ABSTRACT Due to the vast number of potential drug combinations, “testing them all” in clinical trials is impossible, putting pressure on preclinical research to find the most promi...
Augmenting focused ultrasound-mediated drug delivery to brain tumors with vascular normalization
The blood-tumor barrier (BTB) hinders the delivery and penetration of systemically administered therapeutic agents into the brain tumor microenvironment. The BTB is created by dila...
Develop universal CAR macrophage cell therapy for pancreatic cancer
SUMMARY/ABSTRACT Macrophages (Mφs) are innate immune cells, phagocytes and professional antigen presenting cells, which are crucial for tissue homeostasis and adaptive immune respo...
Engineering bZIP family transcription factors for therapeutic T-cell persistence and effector function
PROJECT SUMMARY Cancer immunotherapy using T cells engineered with a chimeric antigen receptor or T-cell receptor directed against cancer antigens is a promising new therapeutic mo...
High-throughput assessment of chemotherapy-induced cardiotoxicity in 3D human cardiomyocytes
High-throughput assessment of chemotherapy-induced cardiotoxicity in human cardiospheres Project Summary Chemotherapeutic agents including both traditional drugs (e.g., anthracycli...
Randomized Controlled Trial of a Hybrid-Delivered Cognitive Behavioral Symptom Management and Activity Coaching Intervention for Stem Cell Transplant Patients
Our objective is to use novel mobile health (mHealth) behavioral intervention approaches to enable patients who have undergone hematopoietic stem cell transplant (HCT) to effective...
Development of Chimeric Antigen Receptor Phagocytes Against Glioblastoma
Project Abstract: Pediatric HGGs comprise glioblastoma [glioblastoma multiforme (GBM)], anaplastic astrocytoma, and diffuse intrinsic pontine glioma (DIPG) and collectively are the...
Development of fast diffusion magnetic resonance fingerprinting of the prostate to avoid unnecessary biopsies
Abstract The most common malignancy for men in the western world is Prostate cancer (PCa), with a predicted 288,300 new cases and 34,700 specific deaths in 2023. With recent develo...
Predicting Endocrine Therapy Response In Male Breast Tumors
PROJECT SUMMARY/ABSTRACT Male breast cancer is critically understudied due to both the rarity of the disease and the exclusion of men from breast cancer trials leading to a signifi...