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20,252 grants found
Showing 881 – 900 of 20,252 grants
Uncovering therapeutic vulnerabilities in AML through mechanistic interrogation of MECOM activity
Project summary Despite recent progress in the understanding of the biological underpinnings of acute myeloid leukemia (AML) and advances in the treatment of patients with AML, few...
Elucidating the Role of the Vaginal Microbiome in Racial Disparities in Precancerous Cervical Lesions: A Multi-level Study
PROJECT SUMMARY Despite progress in human papillomavirus (HPV) vaccination uptake, about three million women are still diagnosed with precancerous cervical lesions each year in the...
Evaluating a novel policy to increase access to nicotine replacement therapy in community retailers
ABSTRACT There is a strong rationale to prioritize tobacco control policy interventions in communities at high risk for tobacco product exposure, lower access to pharmacies, and as...
Exploring the epigenetic control of pancreatic cancer subtypes
PROJECT SUMMARY (from parent grant) Pancreatic ductal adenocarcinoma (PDA) is a leading cause of cancer-related mortality in the United States. Unfortunately, both genomic and tran...
Text and Talk: A multi-level intervention to increase provider HPV vaccine recommendation effectiveness
PROJECT SUMMARY Understanding the factors related to for whom and why evidence-based human papillomavirus (HPV) vaccine implementation strategies are effective and sustainable will...
TweenVax: A comprehensive practice-, provider-, and parent/patient-level intervention to improve adolescent HPV vaccination.
PROJECT SUMMARY/ABSTRACT Persistent human papillomavirus (HPV) infection is responsible for over 30,000 new cases of cancer annually in the United States (US). HPV infection can be...
A novel, glutathione-dependent metabolic pathway drives metastatic outgrowth in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDA) is a leading cause of cancer-related death in the US, for which treatment remains basically unchanged in the past three decades. Although pat...
Elucidating the Role of Tryptophan Hydroxylase 1 in Neuroendocrine Prostate Cancer
Project Summary/Abstract: Neuroendocrine prostate cancer (NEPC) is a fatal prostate cancer (PC) subtype with aggressive clinical features and a poor prognosis. Although it rarely o...
Disparities in Financial and Clinical Outcomes among Commercially-Insured Cancer Patients following the Affordable Care Act
Project Summary/Abstract Demographic changes in the commercially insured population following implementation of the Affordable Care Act (ACA)—specifically improved enrollment of th...
Designing implementation strategies for introducing screening clinical breast examination to primary health centers in Johannesburg, South Africa
PROJECT SUMMARY / ABSTRACT The primary goal of this research proposal is to provide Dr. O’Neil with four years of training and research experience in implementation science and mix...
Stress-induced immunosuppression via downregulation of interferon in triple negative breast cancer
PROJECT SUMMARY Triple negative breast cancer (TNBC) is the most aggressive form of breast cancer (BC) which occurs more frequently in younger women, often diagnosed once the disea...
Smart CSF Delivery System for CNS Drug Therapy for Leptomeningeal Disease
Project Summary / Abstract Cancer cells that enter the brain are difficult to treat with standard intravenous administration of chemotherapies due to the blood-brain barrier. Intra...
Long term radiation treatment planning in brain tumors in the pediatric population
Project Summary and Abstract Radiation therapy (RT) has a proven record of efficacy in treating many forms of pediatric brain tumors. However, it is associated with long-term side...
Deciphering and modulating CAR T cell persistence with controllable epigenome editors
PROJECT SUMMARY While chimeric antigen receptor (CAR) T cell therapy has dramatically altered the cancer therapy landscape, the susceptibility of CAR T cells to succumb to exhausti...
The Mutagenic Effects of APOBEC3A and APOBEC3B in Urothelial Carcinoma
PROJECT SUMMARY & ABSTRACT Abstract As the most common malignancy of the urinary tract among men and women, bladder cancer is estimated to surpass 80,000 new cases and 17,000 d...
Duke Research Training Program in Surgical Oncology
ABSTRACT This training grant application seeks funding for the Duke Research Training Program in Surgical Oncology in the Duke University Department of Surgery. The new submission...
Deciphering the Roles of STING-Mediated T cell Pyroptosis in Antitumor Immunity
PROJECT SUMMARY An immunosuppressive tumor microenvironment presents a significant hurdle in controlling tumor growth. Activation of the stimulator of interferon genes (STING) prot...
A 4D-tunable hydrogel for the study of the impact of the tumor microenvironment on the development of colorectal cancer
Project Summary/Abstract The goal of this proposal is to develop a platform created from advanced biomaterials that enable novel investigations into the physiochemical roles of the...
BEST CARE for Recurrent NMIBC: BladdEr-Sparing Therapy and Cystectomy As TREatments
PROJECT SUMMARY/ABSTRACT Bladder cancer is the 6th most common cancer in the US and the 4th most common cancer in males. Each year, more than 80,000 people in the US are diagnosed...
Identifying and Addressing Barriers in the Cervical Cancer Treatment Cascade among Women with HIV in South Africa
PROJECT SUMMARY/ABSTRACT The vast majority of women who develop and die from cervical cancer live in low- and middle-income countries.1 In sub-Saharan Africa, geographic inequities...