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20,252 grants found
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The Role of CD3z ITAM (Immunoreceptor Tyrosine-Based Activation Motif) diversity in CAR T cell Force and Function
Chimeric Antigen Receptors (CARs) are a combination of an extracellular single-chain variable fragment region (scFV) that recognizes tumor protein antigens in an MHC independent ma...
Maintenance of genome stability in 3D
Summary Cancer cells harbor signs of genomic instability, including genome rearrangements, which can contribute to tumor development. Faithful DNA repair combats this instability a...
Synthetic lethal targeting of KRAS/KEAP1 co-mutant non-small cell lung cancer
Abstract Activating KRAS mutations occur in 20-40% of non-small cell lung cancers (NSCLCs). About 20% of the KRAS mutation tumors have co-occurring mutations of KEAP1 that are resi...
Decoding glioma evolution and progression by multi-dimensional single-cell profiling
PROJECT SUMMARY / ABSTRACT Research Plan: Tumor evolution is a fundamental obstacle to cancer treatment, as malignant cells adapt to treatment and change during progression. Unders...
Adapting flow cytometry methods for early detection of acute hematologic malignancies in Kenya including the improvement of sample flow processes and technical training of personnel
The ability to diagnose and classify leukemias and lymphomas (LLs), in children and young adults is limited in Kenya and most of Sub-Saharan Africa. LLs represent nearly half the c...
3D bioengineered microfluidic platform for research on Ewing sarcoma bone metastasis
Ewing sarcoma (ES) is a pediatric malignancy, which carries adverse prognosis in its metastatic form. Bone metastases, although less common, associate with the worst clinical outco...
Tumor and Host Immune signatures associated with health disparities in outcomes following GD2 immunotherapy in neuroblastoma
PROJECT SUMMARY Neuroblastoma (NB) is the most common extracranial solid tumor of childhood that leads to a disproportionate number of childhood cancer deaths and an even more disp...
Targeting the ROR2/p-GSK3bS9 pathway to suppress metastasis in SMARCA4-deficient lung adenocarcinoma
Metastatic lung cancer kills >160,000 people in the US annually, and 10%-50% of patients with surgically resected lung cancer will develop distant metastasis. There remains an u...
Incidental diagnosis of clonal hematopoiesis among healthy, unrelated, hematopoietic stem cell donors: A feasibility study of psychosocial, ethical, and clinical issues
Abstract The overall goal of this line of research is to examine the psychosocial, ethical, and clinical implications of incidental medical findings of clonal hematopoiesis (CH) in...
Biomaterial Scaffolds for Ex Vivo and In Situ CAR-T Cell Production
PROJECT SUMMARY Despite unprecedented clinical success of chimeric antigen receptor (CAR)-T cell therapy against tumors, widespread application is limited by lengthy and labor-inte...
Modulating Intratumoral Immune Composition to Enhance Immunotherapy
PROJECT SUMMARY The immediate objective of our proposal is to increase immune density within solid malignancies to rectify defects in anti-tumor immunity and maximize response rate...
Mechanism and approach to inactivate mutant KRAS of lung metastatic colon cancer by RNA-ligand-displaying exosome to co-deliver dCas9--gRNA ribonucleoprotein complex and KRAS siRNA
PROJECT SUMMARY Targeted nanotechnologies have shown great promise in overcoming roadblocks in cancer therapeutics. Tumor metastasis has a limited response or resistance to chemoth...
Characterizing the theranostic potential of DLL3-targeting agents in high-grade neuroendocrine carcinomas of the lung and prostate
PROJECT ABSTRACT Small cell lung cancer (SCLC) and neuroendocrine prostate cancer (NEPC) are aggressive, high-grade neuroendocrine neoplasms (HG-NENs) that often metastasize and do...
Mechanisms of DNA methylation signaling and dysregulation in colon cancer
PROJECT SUMMARY Colon cancer is a leading cause of cancer-related death for both men and women in the United States. Abnormal DNA methylation patterning is an epigenetic hallmark o...
A large-scale quasi-experimental evaluation of added sugar warning labels in restaurants
PROJECT SUMMARY In November 2023, New York City (NYC), NY became the first jurisdiction in the US to adopt an added sugar warning policy, which requires restaurants to display a wa...
Characterizing CAFs in Metastasis as a Function of Breast Cancer Cell Phenotype
Project Summary Breast cancer (BC) is the most frequently diagnosed cancer in women. In addition, metastatic BC has a 5-year survival rate of only 27% and metastases are associated...
Targeting drivers of tumor heterogeneity to block the progression to neuroendocrine prostate cancer
PROJECT SUMMARY/ABSTRACT Despite advances in the development of highly effective androgen receptor (AR)-directed therapies for the treatment of men with advanced prostate cancer, a...
Stomal Senescence Regulator of Tumor Immunity and Progression
Project Summary The 5-year survival rate for patients diagnosed with pancreatic ductal adenocarcinomas (PDACs) is 11%. This poor outcome is due to multiple factors, including rapid...
Central mechanisms of glucocorticoid circadian rhythm dysfunction in breast cancer
Project Summary Breast cancer is still the most common malignancy in women worldwide. Despite the incredible advances made in the past decades towards eliminating breast cancer, ne...
Calming the Cytokine Storm: Unraveling the Biology of CRS and ICANS
PROJECT SUMMARY/ABSTRACT Chimeric antigen receptor T-cells (CART) have revolutionized cancer therapy. However, CART cause two common and severe toxicities: Cytokine Release Syndrom...