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20,252 grants found
Showing 841 – 860 of 20,252 grants
NRF2 suppression of inflammatory signaling and its role in tumor progression
Project Summary/Abstract Tumor metastasis is responsible for the vast majority of deaths from epithelial cancers, including breast cancer. Understanding how cancer cells spread to...
Alternative splicing and isoform expression as mediators for the genetic etiology of breast cancer
ABSTRACT A drawback of genome-wide association studies (GWAS) for breast cancer risk and related phenotypes is their limited insights into genotype-to-phenotype mechanisms for iden...
The resurgence of antibody-drug conjugates via PMPC-polymer engineering
Project Summary: We have patented a novel polymer-based in vivo-delivery platform for therapeutic antibodies using a super- hydrophilic polymer, poly 2-methacryloyloxyethyl phospho...
Harnessing the potential of pharmacological small molecules to amplify VSV-based oncolytic viral therapy
Abstract Malignant cutaneous melanoma is the most lethal form of all skin cancers causing 10,000 deaths annually in the United States and 200,000 globally and remains a major oncol...
Immunosurveillance of breast glands with oncogenic germline mutations
Project Summary/Abstract The overarching goal of the proposed research is to realize the immune system's potential for breast cancer prevention in BRCA mutation carriers. Immu...
Implementation of Comprehensive Survivorship Care Intervention Across FQHC-Based Primary Care Practices
Implementation of a Comprehensive Survivorship Care Intervention Across FQHC-Based Primary Care Practices PROJECT SUMMARY Cancer survivorship challenges adversely contribute to can...
2024 Chromatin Structure and Function Gordon Research Conference and Gordon Research Seminar
Project Summary This proposal requests support for the 2024 GRC and GRS meeting on Chromatin Structure & Function (focus on “Chromatin's Impact on Genome Function Across S...
Engineering mRNA encapsulated extracellular vesicles for in vivo chimeric antigen receptor macrophage therapy for glioblastoma
PROJECT SUMMARY Glioblastoma (GBM) is the most common and lethal primary central nervous system cancer in adults, where treatments are ineffective and often debilitating. Unlike ma...
Statistical Methods for Identification and Evaluation of Predictive Biomarkers in Cancer
Project Summary Relapsed/refractory cancer is a principal cause of cancer-related death. Targeted therapies, which represent a new generation of cancer therapies, have advanced the...
Development of a PET CCR2 Imaging Agent to Profile PDAC Microenvironment
Project Summary Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer. PDAC is the 4th leading cause of cancer related death with a 5-year survival rate
Integration of CSF Proteogenomics in the Diagnosis and Management of Diffuse Gliomas
Project Summary Diffuse gliomas are the most common primary malignant adult brain tumor. Lower grade gliomas (Grade 2) inevitably become malignant, and prognosis is fatal. Key clin...
Deciphering mechanisms of transcriptional repression which drive midline glioma
PROJECT ABSTRACT: Diffuse midline glioma (DMG) is a universally lethal form of brain cancer that affects both children and adults, with most patients passing away within 1-year of...
Epigenetic and metabolic bottlenecks of tumorigenesis
Recurrent metastasis is the leading cause of breast cancer mortality. Dormancy is a critical, but poorly understood, step in the tumorigenic process where breast cancer cells can r...
Cancer Undergraduate Research Education Program
ABSTRACT Cancer disproportionately affects Black Americans and other economically disadvantaged groups, yet these individuals are underrepresented in cancer research. The Cancer Un...
IAP inhibition as a therapeutic strategy to target therapy-resistant leukemia initiating cells
Acute myeloid leukemia (AML) is a devastating malignancy with dismal outcomes for patients, particularly in the elderly where most cases occur. The recent approval of the BCL2 inhi...
Using real-time data capture to examine implicit attitudes as mediators of physical activity adherence in interventions
PROJECT SUMMARY Approximately 42% of new cancer cases in the U.S. are viewed as potentially avoidable, including 15% caused by excess body weight and physical inactivity. However,...
Employing quantitative image analysis based on deep learning to improve treatment efficacy in image-guided renal tumor ablation
Image-guided thermal ablation (IGTA) is a minimally invasive, low cost, and accessible cancer treatment for patients including those who are too ill to be candidates for surgery or...
Tumor stem cell initiated mitochondrial transfer
Project Summary/Abstract Cancer is a metabolically heterogeneous disease. At the core of most metabolic pathways, mitochondria play central roles in cancer cell proliferation, migr...
Peptide multimer for early detection of hepatocellular carcinoma
The incidence of hepatocellular carcinoma (HCC) is rising rapidly worldwide. In the U.S., this cancer is growing at a rate faster than that of any other cancer. New biomarkers spec...
Multiplex Epitope Editing to Enable Novel Immunotherapies for Acute Myeloid Leukemia
PROJECT SUMMARY While immunotherapies have proved compelling efficacy against other leukemias, their application for acute myeloid leukemia (AML) is still hampered by the absence o...