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20,252 grants found
Showing 821 – 840 of 20,252 grants
Investigating a Novel Inhibitory Receptor in Regulating CAR-T Cell Persistence and Function
ABSTRACT Chimeric antigen receptor (CAR)-engineered T cell therapy is a breakthrough immunotherapy for lymphoma. Nevertheless, 40-60% of responding patients relapse, in part due to...
Couples' Communication about Sexuality when Facing Metastatic Breast Cancer
7. PROJECT SUMMARY/ABSTRACT Cancer diagnosis, treatment, and management can challenge romantic relationships. For individuals in committed partnerships, cancer is a dyadic endeavor...
Development of a Bioengineered Therapeutic Device for the Prevention of Lymphedema
ABSTRACT: Lymphedema affects approximately 200 million patients globally, and it is characterized by the accumulation of lymph fluid in soft tissues due to obstructions in the lymp...
Targeting transcriptional addiction in fusion-driven sarcoma
7. Project Summary/Abstract The overarching goal of this NGC Center is to leverage expertise in small molecule drug discovery, target identification, and protein and IDR biochemist...
Evaluating the role of SPAK and OSR1 kinases in glioblastoma chemotherapy resistance
Project Summary Glioblastoma (GBM) is the most devastating brain neoplasm with high morbidity and mortality. Despite multimodal treatment including surgery, radiotherapy, and chemo...
Designer extracellular vesicles for cancer therapy
SUMMARY This proposal aims to translate our engineered extracellular vesicles (EVs) into an effective cancer therapy. Major barriers to effective chimeric antigen receptor (CAR)-T...
Investigating the impact of chromosomal instability on prostate cancer aggressiveness
PROJECT SUMMARY Prostate cancer (PC) is a leading cause of male cancer-related deaths. Once disseminated PC is incurable as it gradually progresses to all therapeutic options. The...
Development of Deep Mutational Scanning with Duplex Sequencing (DMS-DS) for anti-cancer drug evaluation and administration
Cancer remains a leading cause of death worldwide. Targeted agents have dramatically improved the prognosis of over 30 cancer types, but are fundamentally limited by the evolution...
Material Stiffness Directs Oral Cancer Migration
Project Summary Oral squamous cell carcinoma (OSCC) is the sixth most common epithelial cancer worldwide with 50,000 new cases/year in US. Despite being less frequent, survival rat...
KanSurvive 2.0
Project Summary/Abstract Cancer survivors require long-term and coordinated care to address the physical, emotional, and psychosocial effects of cancer and its treatment. Rural can...
A national Asian American cohort for assessing multi-level determinants in cancer etiology: the ASPIRE Cohort
Abstract Asian Americans are the fastest growing and most diverse U.S. racial/ethnic group. They have unique and disparate patterns of cancer, including being the first U.S. racial...
A Mechanoimmunological Basis for Metastatic Site Preference
This proposal outlines a three-year training plan in cellular immunology and mechanobiology, offering the applicant diverse expertise in these fields. The sponsor's laboratory...
Targeting TEAD in melanoma drug-tolerant persister cells
ABSTRACT Resistance is still a limitation of immune checkpoint antibodies and MAPK pathway-targeted inhibitors. Drug- tolerant persister cell populations are thought to contribute...
Rewiring Cancer-Induced Abnormalities in the Vascular Barrier
Summary Tumors are known to induce the formation of unique microenvironments in distant organs that facilitate seeding, survival, and growth of metastatic nodules. These sites, kno...
Investigating SLC46A3 as a negative regulator of nanoparticle drug delivery
PROJECT SUMMARY Nanoparticle-based therapies have many potential advantages for treating cancer, but there are currently no clinical biomarkers to predict which patients are most l...
Therapeutic targeting for translocation renal cell carcinoma
SUMMARY Translocation Renal Cell Carcinoma (tRCC) represents a rare subtype of kidney cancer associated with aggressive behavior and poor clinical outcome. The prevalence of this d...
Modeling Marginal Zone Lymphomagenesis
Project Summary Marginal zone lymphomas (MZL), the second most common subtype of indolent lymphomas, is a B-cell malignancy where the tumor microenvironment plays an important role...
Targeting base damage repair in BRCA-mutant cancers
PROJECT SUMMARY/ABSTRACT Poly (ADP-ribose) polymerase inhibitors (PARPi) are a mainstay for the chemotherapeutic regimen of BRCA mutant ovarian and breast cancers. Despite initial...
HPV and host factors in juvenile onset recurrent respiratory papillomatosis
ABSTRACT. Patients with juvenile-onset recurrent respiratory papillomatosis (JoRRP) suffer from recurring epithelial papillomas along the respiratory tract caused by low-risk H PV...
Mechanisms of Androgen Receptor Inverse Agonists in Advanced Prostate Cancer
ABSTRACT Nuclear receptors are steroid-dependent transcription factors that confer cell identity and function. They guide development, and maintain homeostasis in adult tissue, suc...