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20,252 grants found
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Circadian regulation of astrocytic adenosine kinase in the irradiated and cancer brain
ABSTRACT Cranial radiotherapy (CRT) for CNS cancers leads to debilitating cognitive decline that is particularly concerning for pediatric and grade II/III brain cancer survivors. C...
3' RNA modification enzymes regulate tumor angiogenesis in non-small lung cancer
Lung cancer is the leading cause of cancer-related mortality in the United States, and non-small cell lung cancer (NSCLC) comprises over 80 percent of all types of lung cancer. The...
Biological Methylation: Fundamental Mechanisms
Abstract: The purpose of this R13 submission is to request funds to support a limited number of trainees, individuals identifying as underrepresented minorities (URMs), junior inve...
3D wearable NIR spectral tomography for early prediction of breast cancer’s residual cancer burden after neoadjuvant chemotherapy
Prediction of Residual Cancer Burden (RCB) early in treatment can enhance long-term survival outcomes for breast cancer patients undergoing neoadjuvant chemotherapy (NAC) and their...
Molecular Functions of BRCA2 and RAD51 Paralogs in Homologous Recombination and Chromosome Maintenance
Project Summary/Abstract The broad objective of this proposal is to understand the molecular mechanism of homologous recombination (HR) in humans, and to understand how the consequ...
Role of disparities and aging biomarkers in accelerated cardiac aging among adolescent and young adult cancer survivors
PROJECT SUMMARY AND ABSTRACT Cancer in adolescents and young adults (AYA) is defined as a diagnosis in individuals aged 15-39-years and is diagnosed in approximately 90,000 AYAs ea...
Function of PD-1 Signaling on the Activity of B cells in the Tumor Microenvironment in Breast Cancer
ABSTRACT The success of PD-1-targeted immune checkpoint inhibitor (ICI) therapy has revolutionized cancer treatment, becoming a new standard of care for various types of cancer. Ho...
Investigating treatment strategies & clinical outcomes of histotripsy for complete ablation of osteosarcoma
Project Summary Osteosarcoma (OS) is a common and devastating primary bone tumor affecting both humans and canines. Histotripsy is an emerging non-thermal ablation modality that us...
Automated rapid colonoscope insertion device to reduce physician injury and improve productivity
Colon cancer causes over 50,000 deaths each year in the US (12% of total cancer deaths). Colonoscopy (over 16 million procedures/year) is the most effective procedure for diagnosis...
Ultra-Small Epigenetic-Regulating Nanocarrier for Enhanced Synthetic Lethal Therapy
Project Summary: PARP inhibitors-based synthetic lethal therapy, such as BMN673 (Talazoparib), shows great efficacy for BRCA mutated (or homologous recombination repair (HRR)-defic...
Improving Sexual and Reproductive Health Communication Between Adolescent and Young Adult Oncology Patients and Clinicians: A Patient-Centered Intervention
PROJECT SUMMARY/ABSTRACT A cancer diagnosis directly threatens sexual and reproductive health (SRH), an essential component of healthy development in adolescents and young adults (...
Positive Psychology Intervention for Hematopoietic Stem Cell Transplantation Survivors
PROJECT SUMMARY/ABSTRACT Overview: The goal of this project is to assess the efficacy of a tailored phone-delivered positive psychological intervention (PATH) for improving anxiety...
Defining signatures of epigenetic sensitization to lung cancer in a mouse model
PROJECT SUMMARY Epigenetic perturbations in cancer are widely recognized but poorly understood. A detailed understanding of how latent epigenetic information contributes to tumorig...
Estimating Overdiagnosis After Implementation of Lung Cancer Screening in Community-Based Healthcare Systems
PROJECT SUMMARY/ABSTRACT Low-dose computed tomography (LDCT) has been accepted as an efficacious population-based approach for lung cancer screening (LCS) based on findings from th...
Mindfulness Intervention for Sleep Disturbance and Symptom Management in Hematologic Cancer Patients During and After Inpatient Treatment
Patients with life-threatening hematologic cancer experience insomnia and fatigue, distress, and pain symptoms that worsen insomnia during and following hospitalization for high-do...
Hp1bp3 oversees chromatin remodeling to slow tumor growth in high grade glioma
PROJECT SUMMARY High grade glioma (HGG) is the most common malignant brain tumor in adults and is universally lethal. The standard of care for HGG has remained unchanged for over 3...
Developing KSHV-Infected Lymphatic Endothelial Cell-Based Models of Kaposi’s Sarcoma
PROJECT SUMMARY Kaposi’s Sarcoma-associated herpesvirus (KSHV) causes the AIDS-defining cancer Kaposi’s Sarcoma (KS). How KSHV infection causes KS is poorly understood, primarily d...
Small molecule inhibitors of Slit2/Robo signaling as novel therapeutics for glioblastoma
PROJECT SUMMARY/ABSTRACT: Glioblastoma (GBM), the most prevalent malignant primary brain tumor, is an extremely aggressive form of diffuse glioma originating from astrocytic lineag...
Melanocyte PDL1 control of UVB-induced IFN-I
This new R01 proposal assembles a team with expertise in tumor immunology and immunotherapy, mouse cancer models, melanoma, IFN-I signals, tumor signaling, single cell spatial omic...
Integrating Breast Cancer and Cardiovascular Disease Risk to Explore Decision-Making for Chemoprevention Among Racially/Ethnically Diverse Women at High Risk for Breast Cancer
Women with high-risk breast lesions, such as atypical hyperplasia (AH) and lobular carcinoma in situ (LCIS), have up to a 4- to 10-fold increased risk of invasive breast cancer (BC...