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20,252 grants found
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Oncolytic HSV Immunovirotherapy for brain tumors
Glioblastoma (GBM) is a fatal cancer of the brain showing little change in survival over decades of therapeutic trials. Development of oncolytic viruses (OV) is iterative and exten...
Novel applications and translation of [18F]hGTS13, a system xc- specific radiopharmaceutical
ABSTRACT. Ferroptosis is a form of regulated cell death defined by the iron-dependent accumulation of membrane lipid peroxides that results in oxidative damage and plasma membrane...
Unveiling the Role of UBE2J1 as the E2 Ubiquitin Conjugating Enzyme in Androgen Receptor Degradation
PROJECT SUMMARY Despite the significant clinical success of AR-targeted therapies in the management of prostate cancer (PCa), resistance to these treatments remains a significant c...
What is the mechanism by which a gene essential for Rhabdoid tumor viability regulates Chromatin function?
Project Summary Large-scale cancer genome sequencing projects have highlighted the frequency of mutation in chromatin modifiers in cancer. Mutations in genes encoding the members o...
Integrating highly multiplexed immunofluorescence with label-free 2D hyperspectral chemical imaging to interrogate the colorectal cancer tumor-invasive front
Project Summary/Abstract Colorectal cancer (CRC) is the second most common cause of cancer-related death in the United States. Despite advances in both diagnostic and therapy, a la...
Non-invasive cancer detection and residual disease monitoring by cell-free nucleic acid from saliva
Cancer is one of the leading causes of death globally and detection, continuous monitoring and effective treatment are critical for improving patient outcomes. Currently, cancer di...
Genetic predisposition and misdiagnosis of cancer in All of Us participants
SUMMARY/ABSTRACT The National Cancer Institute estimates ~40% of persons in the United States will be diagnosed with cancer at some point in their lives (https://www.cancer.gov). W...
Translating glycans into biomarkers
Alterations in glycosylation have been associated with the development and progression of many types of cancers and other chronic and acute diseases. Structural glycan analysis on...
Investigating mechanisms of tumor plasticity in human bladder cancer
Project Summary/Abstract The progression of bladder cancer from non-invasive to muscle invasive disease represents a critical step that is associated with adverse clinical outcomes...
Interrogating the relationship between translational dynamics and non-canonical antigen presentation in lung cancer
ABSTRACT Antigen presentation is a fundamental component of cancer immunity. The primary cytotoxic effectors of cancer immunity are CD8+ T cells, which recognize peptide antigens p...
Epidemiologic study of microplastic pollution in bronchoalveolar lavage fluid and its association with lung cancer
ABSTRACT An estimated 400 metric tons of plastic are produced each year worldwide and less than 10% is recycled. Microplastics (MPs) defined as particles
WASp signaling in T-cell lymphomas
ABSTRACT Title: WASp signaling in T-cell lymphomas Peripheral T-cell lymphomas (PTCL) are aggressive disorders, with less than 50% overall survival after 2-3-years of diagnosis. Th...
Targeting FGFR Alterations in Gastroesophageal Cancer
PROJECT SUMMARY Gastroesophageal adenocarcinoma (GEA) is the 4th leading cause of cancer deaths worldwide with a median survival of 6.2 months for patients who present with metasta...
ATG16L1 isoforms and CRC health disparities
Compared to non-Hispanic Whites (NHW), African Americans (AAs) are 20% more likely to get colorectal cancer (CRC) and 40% more likely to die from CRC. The negative impacts of healt...
Deconvoluting the contributions of the IFNy pathway components to lung TME and tumor immunity
Project Summary The approval of anti-PD1/PD-L1 and anti-CTLA immune checkpoint blockade (ICB) therapies for those with non- small cell lung cancer (NSCLC) has demonstrated that imm...
Characterizing DC-specific mechanisms of LNP immunogenicity to enhance LNP-based anti-tumor therapies
PROJECT SUMMARY In the first 6 months after COVID-19 vaccine approval, 3.4 billion doses were administered globally, potentially saving 7.2 million lives. Lipid nanoparticle (LNP)-...
Circulating tumor cell profiling for genomic contributors to racial disparity in metastatic prostate cancer
PROJECT SUMMARY/ABSTRACT In the United States, prostate cancer is the most prevalent malignancy, with disproportionately higher incidence and mortality rates among black men than t...
A novel role for EZH2 in PARP regulation and PARPi-resistance in prostate cancer
Prostate cancer is the leading cause of cancer-related deaths in American men. It is estimated that each year more than 180,000 new prostate cancer patients will be diagnosed, and...
Elucidating resistance mechanisms and enhancing response to immune checkpoint blockade in central nervous system metastases from breast cancer
PROJECT SUMMARY Metastases to the central nervous system (CNS) are a common complication of breast cancer. Prognosis is typically on the order of a few months. Immunotherapies have...
Systems Approaches to Cancer Biology Meeting
SUMMARY The Systems Approaches to Cancer Biology (SACB) meeting aims to bring together scientific leaders and early-stage investigators in Cancer Systems Biology to build and foste...