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20,252 grants found
Showing 61 – 80 of 20,252 grants
Virtual Mindful After Cancer Intervention to Promote Sexual Health for Breast and Gynecologic Cancer Survivors
PROJECT SUMMARY Sexual concerns are among the most common, distressing, and persistent aspects of life after cancer. For at least half of breast and gynecological cancer survivors,...
Investigating Feasibility and Acceptability of the FearLess Protocol for Patients with Primary Malignant Brain Tumors and Their Caregivers
PROJECT SUMMARY / ABSTRACT Fear of cancer recurrence (FCR) is alarmingly high among patients with primary malignant brain tumors, who face the certainty of tumor recurrence given t...
Genetically-encoded molecular imaging of genome-edited immune cells
Project Summary Adoptive cell transfers constitute a new paradigm in cell-based therapeutics with wide-ranging applications from neurodegenerative, cardiovascular, autoimmune disor...
Enhancing radioligand therapy for prostate cancer with biomarker and dosimetry guided personalization
ABSTRACT Radiopharmaceutical therapy (RPT) that delivers targeted cytotoxic radiation to cancer cells is typically administered on a fixed activity basis, without personalization,...
A liver digital twin for personalized cancer therapy
Project Summary/ Abstract Our long-term objective is to improve the efficacy and safety of liver cancer transarterial embolization through new computational tools that enable the d...
Monitoring Immunotherapy Response via Gene Silencing Landscapes in Cell-Free DNA
ABSTRACT: Immunotherapies produce remarkable, long-term responses in subsets of patients with non-small cell lung cancer, but unfortunately, most patients do not respond to such tr...
Assessment of germline variants associated with immune-related adverse events following immune checkpoint inhibitors
PROJECT SUMMARY Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment but come with the significant downside of immune-related adverse events (irAEs), which can...
Spatially resolved multi-omics sequencing of FFPE tissues at cellular level
Project Summary Studying tumors in a spatial context will advance our understanding of intratumoral heterogeneity and how the complex interactions between cancer and surrounding no...
Pathways to Resilience of Social Networks of Older Adults with Advanced Cancer
Our study will address the goals of RFA-AG-24-025 by elucidating how the pathways by which key aspects of social connectedness in social networks (SNs)—structural characteristics,...
COMBINATION HIGH-LET MOLECULAR RADIOTHERAPY OF RELAPSED REFRACTORY NEUROBLASTOMA
PROJECT SUMMARY There is a critical need for more effective treatments for metastatic and relapsed neuroblastoma (NB), the most commonly diagnosed extracranial solid cancer in chil...
Development of a novel pan-cancer CAR-T product against AML and Glioblastoma
Despite therapeutic advances outcomes are still poor for patients with most relapsed/refractory malignancies. Recently CAR-T cell therapies have demonstrated significant potential...
Determining the Feasibility of Virtual Tailored, Music-Based Relaxation for Anxiety Among Adolescent and Young Adult Cancer Survivors.
Clinical Problem: Up to 48.5% of adolescent and young adult (AYA, 15 – 39-years old) cancer survivors experience clinically relevant anxiety. Anxiety disrupts the successful achiev...
Research Capacity Building by a Clinician Scientist within the Michigan Cancer Research Consortium- National Community Oncology Research Program
PROJECT SUMMARY/ABSTRACT This Clinician Scientist project is proposed by Elie Dib, MD, MS, FACP, a member of the Michigan Cancer Research Consortium (MCRC)-National Community Oncol...
Multimodal AI Fusion Model for Early Detection for Pancreatic Cancer
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC), accounting for 90% of all pancreatic cancers, is among the deadliest, due largely to late-stage diagnosis and the aggressiv...
Addressing cancer disparities in Nigeria through Immuno-oncology Research – The NOLA Program
PROJECT SUMMARY – OVERALL In the US and other high-income countries, immunotherapy is transforming the management of some cancers, including colorectal cancer (CRC). However, immun...
Administrative Core
PROJECT SUMMARY/ABSTRACT – ADMINISTRATIVE CORE The Administrative Core of the Nigerian Immuno-Oncology Research (NOLA) program will provide centralized scientific leadership, exper...
Research Project
PROJECT SUMMARY/ABSTRACT – RESEARCH PROJECT Outcomes for cancer patients in low- and middle-income countries (LMIC) like Nigeria are poor compared to high-income countries (HIC). A...
A Dose Expansion Study of SX-682 Alone and in Combination with Decitabine in MDS Patients
Myelodysplastic syndromes (MDS) are genetically and morphologically diverse hematopoietic neoplasms that arise from a small pool of mutant clones within hematopoietic stem and prog...
National and Institutional Leadership and Support of NCI-Sponsored Clinical Trial Research as a Surgical Oncologist
Project Summary: Dr. Akhil Chawla plays a pivotal role in the NCI clinical trials program at Northwestern University Robert H. Lurie Comprehensive Cancer Center (RHLCCC). As a Surg...
A SYSTEMS THEORY APPROACH TO THE STUDY OF COLON AND LUNG CANCER HEALTH DISPARITIES USING NOVEL DATA LINKAGES
Abstract We will conduct innovative linkages between our state cancer registry, all-payer claims data, and mental health treatment sources from the South Carolina Integrated Data W...