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20,252 grants found
Showing 761 – 780 of 20,252 grants
Developing a novel agonist of CD137 for cancer immunoprevention
PROJECT SUMMARY The primary objective of this proposal is to assess a novel agonist of 4-1BB costimulatory pathway, SA-4-1BBL, as a single agent for cancer immunoprevention in prec...
High-risk hepatoblastoma dissemination control by oncogenic NRF2
Hepatoblastoma (HB) is the most common liver tumor in children, believed to have the fastest rising incidence of all pediatric solid tumors. Unfortunately, HB has a poor overall su...
CSHL 2024 Mechanisms & Models of Cancer Conference
COLD SPRING HARBOR LABORATORY CONFERENCE MECHANISMS AND MODELS OF CANCER August 13-17, 2024 Recent years have produced transformative discoveries that have revealed the mechanisms...
mHealth Intervention to Support Symptom Communication for Children with Cancer
PROJECT SUMMARY Inadequately managed symptoms caused by their disease and its treatment result in unnecessary suffering for children with cancer that interferes with their quality...
Title: Multi-Site Randomized Controlled Trial of a Novel Digital Application (SHIFT) to Improve Outcomes for Hematopoietic Stem Cell Transplant Survivors
PROJECT SUMMARY/ABSTRACT Overview: The goal of this study is to examine the efficacy of a novel digital application (SHIFT) for improving sexual health outcomes, quality of life (Q...
Preference-Based Treatment Valuation in Low-Risk Thyroid Cancer
Summary/Abstract: This Career Development Award (K08) establishes health state utilities across several established and evolving therapies for low-risk, sub-centimeter thyroid canc...
Role of JMJD4 in Pancreatic Cancer
PROJECT SUMMARY – Role of JMJD4 in Pancreatic Cancer In 2023, nearly 50,000 patients will die from pancreatic cancer in the US. This malignancy has one of the worst survival rates,...
Engineering synthetic feedback control in T cell signaling for anti-tumor immunity
Project Summary Engineered T cells are emerging as promising therapeutic agents against a wide variety of cancers. However, despite remarkable success against blood cancers, these...
Leveraging small molecule inhibitors to improve CD19 CAR T cell immunotherapy for KMT2A-rearranged ALL
PROJECT SUMMARY/ABSTRACT This K08 mentored career development award proposal details a research and training plan that is designed to facilitate the career development and transiti...
A Nurse-Led, Coping and Supportive Care Intervention to Improve Psychosocial Outcomes of Patients with Triple-Negative Breast Cancer During the Transition from Curative Therapy to Surveillance
PROJECT SUMMARY/ABSTRACT Patients with triple-negative breast cancer (TNBC) account for approximately 15% of all breast cancer diagnoses but are disproportionately burdened with me...
Multivalent Small Circular mRNA Vaccines for Melanoma Combination Immunotherapy
Abstract Melanoma is the most serious type of skin cancer. Although immune checkpoint blockade (ICB) therapy has benefited many melanoma patients, most patients do not respond to c...
Macropinocytosis Inhibition as a Glutamine Mimetic Sensitization Strategy in Pancreatic Cancer
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) cells depend on glutamine to meet their unique metabolic needs. Glutamine fuels a wide array of biosynthetic pathways; howev...
Translation Regulation Contributes to Hypoxia Adaptation in Glioblastoma
PROJECT SUMMARY Glioblastoma (GBM) is a CNS tumor derived from glial cells. It is the most common and fatal primary malignant brain tumor in adults with a median survival of 15 mon...
Dissecting and Targeting MAST1 Signaling in chemoresistant Cancers
PROJECT SUMMARY Platinum drugs such as cisplatin serve as a mainstay of cancer therapy, but resistance limits their curative potential. Through a kinome-wide RNAi screen, we identi...
S1PR1-targeted PET imaging to predict and monitor response to HER2-targeting antibody-drug conjugates
PROJECT SUMMARY/ABSTRACT – In patients with gastric cancers who are clinically classified as HER2- positive, antibody-drug conjugates (ADC) prolong progression-free and overall sur...
Quantitative characterization of tumor heterogeneity using habitat imaging for the prediction of patient outcome in triple negative breast cancer
PROJECT SUMMARY The overall goal of this training proposal is to employ quantitative imaging to noninvasively characterize tumor microenvironmental heterogeneity in triple negative...
Variant to Function Mapping of B-ALL Risk Loci
ABSTRACT Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and arises predominantly from developing B-cell precursors. B-cell ALL (B-ALL) remains a leading...
Characterization of Diverse Pediatric Cancers in LMIC Using Low-Cost Nanopore Sequencing
Project Summary / Abstract Virtually fatal 60-years ago, pediatric cancers are now curable for 85% of children who have access to contemporary treatments and robust supportive care...
Alpha-Particle Emitter Peptide Receptor Targeted Radionuclide Therapy for Neuroendocrine Tumors
PROJECT SUMMARY/ABSTRACT Peptide receptor radionuclide therapy (PRRT) with [177Lu]DOTATATE improves quality of life and survival in patients with advanced neuroendocrine tumors; ho...
Monitoring Listeria in vivo using 18FDG and PET scan
ABSTRACT Recently, our lab developed a novel immune therapeutic approach delivering TT as a neoantigen surrogate selectively into tumors by Listeria infection in vivo, which attrac...