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20,252 grants found
Showing 741 – 760 of 20,252 grants
SPORE in Breast Cancer
PROJECT SUMMARY/ABSTRACT: OVERALL Using the well-established framework of a very active and strong multidisciplinary Vanderbilt-Ingram Cancer Center (VICC) Breast Cancer Program th...
The RUNX1 Research Program 8th Annual Scientific Conference and Patient Meeting
PROJECT SUMMARY The main goal of the RUNX1 Research Program 8th Annual Scientific Conference and Patient Meeting is to create a dynamic convening in order to foster collaboration a...
Strengthening Research, Training and Outreach Capacity in Huntsman Cancer Institute's Mountain West Service Area
Project Summary/Abstract Huntsman Cancer Institute (HCI) at the University of Utah is the only NCI-designated Comprehensive Cancer Center in the Mountain West (Idaho, Montana, Neva...
Cancer Center Administration
ADMINISTRATION ABSTRACT Huntsman Cancer Institute (HCI) Administration supports the Cancer Center’s mission to provide excellence in innovative basic, translational, population sci...
Evaluation of the tumor microenvironment in serous uterine cancers
PROJECT SUMMARY This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA- 24-044. Uterine cancer (UC) is the fourth most common...
Combination Therapies Targeting Insulin Signaling in Endometrial Cancer
PROJECT SUMMARY/ABSTRACT Endometrial cancer is the most common gynecologic malignancy in the developed world, and its incidence and mortality rate are increasing due, in part, to t...
Rac guanine nucleotide exchange factors in lung cancer
ABSTRACTKRAS and EGFR mutations are the most prevalent genetic alterations detected in human lung adenocarcinomas, and play essential roles in malignant transformation and disease...
Tumor Microenvironment Determinants of TKI Response in Oncogene-Driven Lung Cancer
1 Research: Tyrosine kinase inhibitors (TKIs) such as alectinib have transformed survival outcomes for patients 2 newly diagnosed with anaplastic lymphoma kinase (ALK) positive non...
Investigating CD4+ T cell memory in cancer immunotherapy
Project Summary/Abstract This proposal encompasses a 5-year research and training plan to support the transition of Dr. Wattenberg to an independent research career. Dr. Wattenberg...
New Proteomics Approaches to Study the Full Human Kinome, Inhibitor Resistance, and Kinase Degraders
Project Abstract Protein kinases constitute one of the largest enzyme families in humans, and their aberrant and carcinogenic function in a vast array of cancers is well known. How...
Optical Genome Mapping As a Novel Diagnostic Approach in Pediatric Brain Tumors
ABSTRACT One of the greatest advances in pediatric brain tumor management has been the incorporation of tumor molecular findings in the diagnosis, prognostic stratification, and tr...
Identifying factors associated with prostate cancer progression and survival in African American men: The RESPOND Cohort
African American (AA) men have a >80% higher incidence and are more than twice as likely to die from prostate cancer (PCa) than white men. The reasons for the high burden relati...
Puerto Rico Cancer Research Meeting
PROJECT SUMMARY The Puerto Rico Cancer Research Meeting (PRCRM), hosted by Universidad Central del Caribe – School of Medicine (UCC-SOM), aims to bridge the gap in cancer research...
Multi-Site Randomized Controlled Trial of a Novel Digital Application (DREAMLAND) to Improve Outcomes for Patients with Acute Myeloid Leukemia
PROJECT SUMMARY/ABSTRACT Overview: The goal of this study is to examine the efficacy of a novel digital application (app) for improving quality of life (QOL) and psychological outc...
Cognition, Vascular Function, and Physical Activity in Colorectal Cancer Survivors
Colorectal cancer (CRC) is the 3rd most common cancer in the United States for both male and females. Advancements in treatment options are successfully helping CRC survivors (CRCS...
Transcriptional Reprogramming in Melanoma Plasticity
Project Summary/Abstract This application focuses on advanced melanoma, a highly aggressive type of skin cancer that arises from the pigment-producing melanocytes of the body. Desp...
Lipid-Rich Macrophages at the Tumor-Adipose Interface: A New Target for Locally-Invasive Prostate Cancer Therapy
SUMMARY Macrophages are important contributors to the biology of the tumor microenvironment. As tumors penetrate the prostatic capsule they invade a lipid-rich depot known as the p...
Targeting Metabolic Vulnerabilities of Triple Negative Breast Cancer Stem Cells
PROJECT SUMMARY/ABSTRACT Triple negative breast cancer (TNBC) is the most aggressive subtype with increased propensity for metastasis and few treatment options. Mounting evidence s...
Targeted Degradation of EGFR and HER2 in NSCLC
Project Summary/Abstract Epidermal growth factor receptor (EGFR), a receptor tyrosine kinase (RTK), is an oncogenic driver that is frequently overexpressed or mutated in non-small...
Lung Cancer Screening: Cumulative Risk and Multilevel Impact of False Positive Findings
ABSTRACT The National Lung Screening Trial demonstrated the efficacy of lung cancer screening (LCS) with low-dose computed tomography in reducing 5-year lung cancer mortality by 20...