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20,252 grants found
Showing 721 – 740 of 20,252 grants
Innovative mRNA vaccines to enhance the efficacy of T-cell transfer therapies against solid tumors
ABSTRACT The remarkable effectiveness of the COVID-19 mRNA vaccines heralds a transformative immunization platform against viral infections. A key innovation—recognized with the 20...
Developing and Testing an Interactive Visual Aid for Approaching Decision Making to Stop Cancer Treatment in Advanced Cancer
PROJECT SUMMARY/ABSTRACT The long-term objective of this K08 Mentored Clinical Scientist Research Career Development Award is to prepare the candidate for an independent research c...
Development and Assessment of Nicotine Continuum of Risk Education on Tobacco Use Among Socioeconomically Disadvantaged Adults
PROJECT SUMMARY Adults who are socioeconomically disadvantaged (“Low-SES”) are at increased risk of heavy smoking, face reduced cessation success, and bear a disproportionate burde...
Defining the genetic mechanisms of ETS1 dependency in Notch-activated T Cell Acute Lymphoblastic Leukemia (T-ALL)
PROJECT SUMMARY Over 60% of T cell acute lymphoblastic leukemias (T-ALLs) harbor mutations in the NOTCH1 signaling pathway, making Notch activation the most common oncogenic pathwa...
Interrogating the Spatial and Functional Relevance of Microbes in Pancreatic Cancer and Metastasis
Abstract/ Summary Pancreatic ductal adenocarcinoma (PDAC) represents one of the most aggressive malignancies, with more than 50% of patients with pancreatic cancer presenting with...
Chemical biological analysis of RAF Kinases
Abstract The serine/threonine Raf Kinases function as downstream modulators of RAS GTPase-driven signaling and are key drivers of many oncogenic signaling networks. Despite extensi...
Tissue-Resident Adaptive CD56bright NK Cell Responses in Cancer
ABSTRACT Natural killer (NK) cells are key mediators of anti-tumor immune responses, acting to directly kill cancer cells (CD56dim subtype) and recruit pro-inflammatory immune popu...
Defining the role of stress granules in cancer initiation
Project Summary. Stress granules (SGs) – cytoplasmic aggregates formed from stalled translation initiation complexes upon cell stress – have emerged as critical regulators of oncog...
SCH: Topological Methods for Breast Tissue Quantification
To better understand breast cancer and its response to treatment, the key is to understand breast tissue architecture. Modifications to tissue architecture are a direct consequence...
SCH: Synchronous Dyadic Physiological Monitoring for Real Time In Vivo Measurement and
Animal-Assisted Interventions (AAIs) are goal-oriented programs that intentionally incorporate animals, such as dogs, for therapeutic benefits. AAIs are widely used in a variety of...
SCH: Robust Multimodal Longitudinal AI for Enhanced Breast Cancer Screening
The overarching objective of this project is to optimize and personalize breast cancer screening by advancing artificial intelligence (AI) algorithms. Breast cancer is a major glob...
Administrative supplement to expand cancer clinical trial capacity in sub-Saharan Africa
SUMMARY This application is being submitted in response to Notice of Special Interest (NOSI) NOT-CA-24-039. Given the rising incidence and poor outcomes associated with cancer in N...
Native American Youths Enjoy Science - YES Oklahoma
PROJECT SUMMARY The “YES Oklahoma” program provides a pathway that sustains an enhanced representation of Oklahoma American Indian students in cancer research. Our program is suppo...
7th Annual Workshop on Confocal Microscopy for Cutaneous Diagnostics
Project Summary Skin cancers are the most common cancers in the U.S and often require biopsy for histopathology confirmation. However, ~70% of biopsies yield benign findings, repre...
Polyploidy and Sex Dimorphism in a Drosophila Tumor Model
Project Summary Ploidy variation is a cancer hallmark and is frequently associated with poor prognosis in high-grade cancers. Such variation can include an increase in chromosome s...
21st International Conference of the Society for Integrative Oncology
PROJECT SUMMARY/ABSTRACT The Society for Integrative Oncology (SIO) 21st International Conference, "Full Circle Translational Integrative Oncology: Bedside to Bench and Back -...
Targeting CD180 to induce anti-KSHV response in nonhuman primates
SUMMARY The overall goals of this U01 application are two-fold. First, to investigate two potential KSHV targets, one structural and one non-structural, to determine if these two t...
Defining Critical Sites of Vulnerability and Correlates of Protection to Kaposi Sarcoma Associated Herpesvirus to Inform Vaccine Design
PROJECT SUMMARY Kaposi sarcoma-associated herpesvirus (KSHV) is an oncogenic virus that causes Kaposi sarcoma (KS), one of the most common malignancies in people living with HIV wo...
Development of a Molecular Assay to Diagnose Malignant Pleural Effusions
Precision Epigenomics Inc, is a University of Arizona Cancer Center and Department of Pathology, spin out, aiming to launch molecular diagnostic tests for cancer patients. The prod...
Cancer Center Administration
ADMINISTRATION ABSTRACT Huntsman Cancer Institute (HCI) Administration supports the Cancer Center’s mission to provide excellence in innovative basic, translational, population sci...