Browse All Grants
20,252 grants found
Showing 701 – 720 of 20,252 grants
Gut Microbiome Profiles in Association with Breast Cancer Recurrence and Mortality
PROJECT SUMMARY While breast cancer prognosis has substantially improved over the last three decades, recurrence remains a significant risk, particularly for African American patie...
CROSSTALK BETWEEN GUT MICROBIOTA AND HEPATOCELLULAR CARCINOMA INDUCED BY METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE
Metabolic dysfunction-associated steatotic liver disease (MASLD) is considered a world-wide public health problem caused by metabolic syndrome. It is estimated that 30% of the worl...
Nonresponse of Patient-reported Outcomes in Routine Cancer Care
PROJECT SUMMARY/ABSTRACT Patient-reported outcome (PRO) measures, or PROMs, are powerful tools in cancer care to enhance clinician- patient communication, identify problematic symp...
Rewired Signaling at the Nexus of Melanoma Metastasis and Resistance
Summary This R35 focuses on novel mechanisms underlying control of key UPR components that impact melanoma metastasis in aged rather than young mice by (i) tumor-intrinsic mechanis...
Elucidating T Cell Ferroptosis in Renal Medullary Carcinoma: 3D Genome Architecture Rewiring and Therapeutic Alleviation
Project Summary The three-dimensional (3D) chromatin architecture in mammals represents a remarkable yet not fully understood biological process. The high-throughput chromosome con...
Modulating cysteine metabolism to induce cell death in small cell lung cancer
SUMMARY Small cell lung cancer (SCLC) is a fatal form of lung cancer whose development is closely associated with tobacco smoking. Patients with SCLC have a median overall survival...
Harnessing DNA methylation in peripheral blood for improved colorectal cancer prevention
PROJECT SUMMARY / ABSTRACT DNA methylation (DNAm) aberrancies are hallmarks of colorectal cancer (CRC) and substantially outnumber somatic mutations. So far, most DNAm studies have...
Epigenetic mechanisms controlling single-stranded DNA lesion sensitivity and mutagenesis
Project Summary: Our long-term objective is to define the epigenetic mechanisms that ensure accurate genome maintenance, and to exploit these findings to improve human health. Sing...
CPMV-Polymer Devices to Enhance the Outcomes of Intratumoral Immunotherapy
CPMV-Polymer Devices to Enhance the Outcomes of Intratumoral Immunotherapy Steinmetz (PI) and her colleagues have developed a plant virus nanoparticle immunotherapy that activates...
Kinase Signaling in Epidermal Homeostasis and Early Neoplasia
PROJECT SUMMARY Kinases are essential to development and deregulation of their activity contributes to cancer progression in multiple human malignancies. We recently demonstrated t...
A Mechanoimmunological Basis for Metastatic Site Preference
Summary Antitumor immunosurveillance by cytotoxic lymphocytes is generally conceived as a biochemical process in which tumor specific markers are recognized by activating receptors...
Colorectal Cancer Screening with Optical Coherence Tomography
The overall incidence rate of colorectal cancer (CRC) has declined over the past two decades largely due to population-based colonoscopic screening for and removal of precursor ade...
Novel PET Imaging to Guide Therapy in Hepatocellular Carcinoma
PROJECT SUMMARY/ABSTRACT: Novel PET Imaging to Guide Therapy in Hepatocellular Carcinoma Liver cancer is the third leading cause of cancer death worldwide, with hepatocellular carc...
Randomized controlled trial of FoRtitude: Targeted eHealth intervention to reduce fear of recurrence among breast cancer survivors in community oncology settings
PROJECT SUMMARY Fear of recurrence (FoR) is a pervasive, distressing concern among breast cancer survivors (BCS) that persists for years after cancer treatment. Long-term survivors...
Regulation of Nuclear Akt by p53, MDM2 and Phosphoinositide Lipids Roles in Oncogenic Transformation and Tumor Progression
PROJECT SUMMARY: 30 lines. The canonical phosphoinositide (PI) 3-kinase (PI3K)/Akt signaling pathway uses free membrane PI lipid to regulate cell growth and is frequently hyperacti...
CD200R blockade for cancer immunotherapy
PROJECT SUMMARY Immunotherapies based on the blockade of immune checkpoints have revolutionized cancer treatment in recent years. Today, immune checkpoint inhibitors in development...
Dissecting and targeting PAK4 in Ewing sarcoma
Ewing sarcoma (ES) is the second most common bone tumor in the pediatric population and is defined by a pathognomonic translocation, most frequently EWS::FLI1, which leads to the e...
Targeting DHX9 to trigger viral mimicry and immunotherapy responsiveness in Small Cell Lung Cancer (SCLC)
PROJECT SUMMARY / ABSTRACT Despite the impressive clinical success of Immune checkpoint blockade (ICB) therapy in cancer, therapy resistance is common and only a small subset of pa...
Intratumoral microbiota and immune predictors of response to immunotherapy in lung cancer
ABSTRACT Although immunotherapy, especially immune checkpoint inhibitors (ICIs), has emerged as a powerful cancer treatment, less than half of advanced Non-Small Cell Lung Cancer (...
Clinical decision-support algorithms for interactive design of patient-specific breast molds
Breast reconstruction can help feminine-presenting individuals retain or regain quality of life by mitigating the impacts of body image disruption due to appearance changes arising...