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20,252 grants found
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FUture Surgeons and Scientists Investigating ONcology
Project Summary The FUture Surgeons and Scientists Investigating ONcology (FUSSION) YES program at the University of Alabama at Birmingham (UAB) is designed to increase interest in...
Survivorship in Patients with Multiple Myeloma Treated with Chimeric Antigen Receptor T-cell Therapy
PROJECT SUMMARY/ABSTRACT Multiple myeloma is the second most common hematologic cancer in the US and remains incurable, with virtually all patients developing relapsed or refractor...
Harnessing naturally occurring cell type-specific regulatory elements and normal HSC hematopoiesis to develop cell lineage-controlled CAR expression and continuously renewing CAR NK cells
Project Summary CAR T cell therapies have been revolutionary for patients with relapsed/refractory hematologic malignancies; however, the relapse rates are unacceptably high, with...
Identifying Multi-Level Predictors and Outcomes of Oral Anticancer Medication Adherence Initiation and Persistence among Patients with Hematologic Malignancies
Oral anticancer medications (OAM) are becoming standard of care for growing numbers of patients. Multiple myeloma (MM), chronic myeloid leukemia (CML), and chronic lymphocytic leuk...
Evaluation of a Proactive Identification and Digital Mental Health Intervention Approach to Address Unmet Psychosocial Needs of Individuals Living with Likely Incurable Cancer
ABSTRACT Individuals living with likely incurable cancer (ILLIC) are a heterogeneous, growing subpopulation of cancer survivors who have unique survivorship care needs. Principal a...
Novel biologic RNA molecules to modulate HCC metabolism
PROJECT SUMMARY Liver cancer is a major cause of cancer-related deaths within the United States, being the fifth and seventh leading cause of cancer deaths among men and women, res...
Engage: A Randomized Controlled Trial Testing the Efficacy of a Telehealth-Delivered Psychosocial Intervention to Decrease Symptom Interference in Patients with Advanced Cancer
Pain, fatigue, and distress are highly prevalent co-occurring symptoms in patients with advanced cancer. When these symptoms interfere with patients’ daily lives, it can diminish t...
Mosaic: RCT of a Digital Health Intervention Delivering Peer Support Narratives and Psychoeducation to English- and Spanish-Speaking Stem Cell Transplant Recipients
Cancer patients undergoing hematopoietic stem cell transplant (SCT) face numerous challenges because of this treatment’s toxicity, lengthy hospitalization and recovery, and persist...
The urinary microbiome and bladder toxicity after pelvic radiotherapy
Project Summary: Most men diagnosed with prostate cancer (PCa) are 65-years of age or older. Radiotherapy (RT) is an effective and curative treatment for early-stage PCa. However,...
Impact of State Cannabis Laws on Cancer Pain Management and Outcomes: A mixed-methods study
PROJECT SUMMARY/ABSTRACT More than one third of the approximately 2 million Americans diagnosed with cancer each year experience moderate to severe pain related to their disease an...
Targeting angiotensin and inflammation to prevent radiotherapy-induced bladder toxicity.
ABSTRACT/SUMMARY Radiotherapy (RT) is an effective treatment modality for pelvic malignancies. However, radiation cystitis (RC) is a widely recognized irreversible and chronic cond...
A Pragmatic Randomized Controlled Trial to Evaluate the Effectiveness of an Intervention to Promote Guideline-Concordant Colorectal Cancer Surveillance
ABSTRACT The transition from curative-intent treatment to survivorship can be an overwhelming and confusing time for patients with colorectal cancer (CRC). Surveillance for cancer...
Genomic Analysis of Inherited Breast and Ovarian Cancer
The discovery of BRCA1 and BRCA2 and other genes of homologous recombination repair, and the characterization of the roles of these genes in inherited predisposition to breast and...
Harnessing Tumor and Circulating-Free DNA Methylation for Prognosis and Treatment Stratification in Adenoid Cystic Carcinoma
Abstract Adenoid Cystic Carcinoma (ACC) is a common salivary gland cancer for which there is no standard systemic therapy. ACC has a heterogeneous behavior; while most patients hav...
Pilot testing of metacognitive strategy training to address cancer-related cognitive impairment in breast cancer
Project Summary/Abstract The long-term goal of this research is to reduce the functional impact of cognitive impairment and improve quality-of-life in women treated for breast canc...
Assess and Design a Multi-level Intervention with Middle to Older Age Mexican Immigrants to Increase Cervical Cancer Screening in Community Health Clinics
PROJECT SUMMARY / ABSTRACT Cervical cancer is the fourth most common cancer affecting people with a cervix worldwide, after breast, colorectal, and lung cancers, with 569,847 new c...
Novel chemokine in the regulation of breast cancer metastasis
Project Summary Our long-term goal is to understand the immunobiology of cancer and identify the molecular drivers that promote the metastatic progression of cancer. We discovered...
De novo designed Ras tools to uncover the mechanisms underlying drug resistance
The Ras family of proteins contain four major isoforms, and altogether these proteins are constitutively activated in a third of cancers. In the past decade, inhibitors to mutant R...
Investigating personalized approaches to de-intensify therapy for nodular lymphocyte-predominant Hodgkin lymphoma
PROJECT SUMMARY/ABSTRACT: Michael Binkley, MD, MS is an Assistant Professor of Radiation Oncology at Stanford University School of Medicine. His long-term career goal is to combine...
Cell-Free DNA Methylation Patterns as a Biomarker for Tumor Biology and Clinical Outcomes for Glioblastoma Patients
ABSTRACT Glioblastoma is a uniformly lethal brain tumor despite aggressive and toxic standard of care treatments including surgery, radiation, and chemotherapy. One of the main bar...