Browse All Grants
20,252 grants found
Showing 641 – 660 of 20,252 grants
Caregivers-Patients Support to Latinx Coping with Advanced-Cancer
Project Summary The goal of this K08 is to prepare the PI, to receive hands-on experience in implementation and dissemination, designing and leading randomized controlled trials (R...
Role of Calreticulin Acetylation on Trafficking in Prostate Cancer
Prostate cancer is the second leading cause of cancer related deaths in American males, and although death rates have declined, it is still the most diagnosed cancer in males. Havi...
E7 TCR-T cell therapy for HPV-associated cancers
PROJECT SUMMARY HPV-associated malignancies include cancers of the cervix, oropharynx, anus, vulva, vagina, and penis. They cause thousands of deaths in the United States each year...
Improving Rates of Diagnostic Colonoscopy in Native Americans through a Culturally Sensitive Digital Outreach Intervention
PROJECT SUMMARY Native Americans (NA) endure a disproportionate burden of colorectal cancer (CRC) incidence and CRC-specific mortality. Screening is an effective early detection st...
Defining the biochemical properties and implications of NRAS mutant-specific BRAF interactions in melanoma
TITLE Biochemical properties and implications of NRAS mutant-specific BRAF interactions in melanoma ABSTRACT Extracellular growth factors promote cellular proliferation, motility,...
Targeting amyloid beta for myeloid reprogramming in brain metastasis
PROJECT SUMMARY/ABSTRACT Many patients with advanced-stage cancer will develop metastatic disease in the brain. Most patients who develop brain metastasis (BM) will succumb to the...
Assessment of consumer response to smokeless tobacco modified risk marketing orders
ABSTRACT Some non-combustible tobacco products, such as various forms of smokeless tobacco (ST), can pose significantly fewer risks to individual users than traditional cigarettes,...
Direct Targeting of MYC in Cancer with Hyperstable Synthetic Transcriptional Repressors
PROJECT SUMMARY Transcription factors (TFs) are master regulators of gene expression and have been implicated in many disease states, including in cancer. Of these, the basic helix...
Barriers and Facilitators for Delivery of Guideline-Concordant Care for Adolescents and Young Adults with Ewing Sarcoma and Osteosarcoma
PROJECT SUMMARY / ABSTRACT Roughly 90,000 adolescents and young adults (AYAs: 15–39) are diagnosed with cancer in the United States each year. Disparities in cancer mortality exist...
Validation and implementation of ctDNA as a clinically informative biomarkerin AYAs with sarcomas.
PROJECT SUMMARY/ABSTRACT Advances in our understanding of disease biology and development of new technologies have made individualized treatment a reality for many patients with ca...
A community health worker intervention to improve lung cancer screening uptake in community health centers serving Black and Hispanic communities
PROJECT SUMMARY: Lung cancer is the leading cause of cancer death, and lung cancer screening (LCS) can reduce lung cancer- related mortality by 20%. However, only 5-10% of eligible...
Enhancing treatments for myeloid leukemia associated with Down syndrome
PROJECT SUMMARY Myeloid Leukemia associated with Down syndrome (ML-DS) patients have high 5-year overall survival (OS) rates when treated exclusively with cytarabine (AraC)-based p...
The role of immunosuppression in the tumor microenvironment in Hispanic/Latino patients with breast cancer
PROJECT SUMMARY: Disparities in cancer outcomes in certain patient populations such as Hispanic/Latino (H/L) patients, are rooted in part in the lack of understanding of biologic f...
The role of immunosuppression in the tumor microenvironment in Hispanic/Latino patients with breast cancer
PROJECT SUMMARY: Disparities in cancer outcomes in certain patient populations such as Hispanic/Latino (H/L) patients, are rooted in part in the lack of understanding of biologic f...
The role of immunosuppression in the tumor microenvironment in Hispanic/Latino patients with breast cancer
PROJECT SUMMARY: Disparities in cancer outcomes in certain patient populations such as Hispanic/Latino (H/L) patients, are rooted in part in the lack of understanding of biologic f...
Race and ancestry as predictors of the tumor immune microenvironment and response to immunotherapy
ABSTRACT: Immunotherapy has led to remarkable improvements in patient survival for many tumor types. In particular, immune checkpoint inhibitors have shown efficacy in many cancer...
Admin Core
ABSTRACT: Immunotherapy has led to remarkable improvements in patient survival for many tumor types. In particular, immune checkpoint inhibitors have shown efficacy in many cancer...
Project-Race and ancestry as predictors of the tumor immune microenvironment and response to immunotherapy
ABSTRACT: Immunotherapy has led to remarkable improvements in patient survival for many tumor types. In particular, immune checkpoint inhibitors have shown efficacy in many cancer...
Creation of the Human Cancer Metabolome Atlas
Project Summary/Abstract Metabolic reprogramming is a hallmark of cancer, prompting molecular mechanisms to promote tumor survival, growth, and resistance to treatment. Therapeutic...
Local nano-immune modulation for the systemic treatment of lymphoma
PROJECT SUMMARY The broad objectives of this K08 proposal are (1) to facilitate the development of necessary skills that will allow the PI, Dr. Adam Lin, to achieve his long-term g...