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20,252 grants found
Showing 621 – 640 of 20,252 grants
Maximizing the efficacy of MDM2 inhibitor therapy for MDM2-amplified glioblastoma
PROJECT DESCRIPTION/ABSTRACT MDM2 amplification occurs in 3.5% of all malignancies and in approximately 10% of several highly aggressive malignancies, including glioblastoma. MDM2...
Deciphering the role of pH regulator Slc4a4 in glioma progression
PROJECT SUMMARY. Malignant glioma is a devastating brain cancer with no improvements in prognosis over decades. One key mechanism for glioma progression is the dynamic metabolic co...
Targeted Radionuclide Therapy to Enhance the Efficacy of CAR T Cells Against Neuroblastoma
PROJECT SUMMARY/ABSTRACT Quaovi Sodji, MD, PhD is a Tenure track Assistant Professor in the Department of Human Oncology at the University of Wisconsin School of Medicine and Publi...
Exploring the Relationship Between the Oral Microbiome and Fatigue in Individuals with Breast Cancer: A Longitudinal Study
PROJECT ABSTRACT Fatigue, the most distressing symptom, affects between 60-90% of all individuals with breast cancer. The prevalence of fatigue increases to 80-96% when these indiv...
Local Administration of Particle-Anchored Cytokines as a Safe and Effective Cancer Immunotherapy
PROJECT SUMMARY / ABSTRACT The primary objective of this proposal is to develop a localized cancer immunotherapy using particle-anchored cytokines with prolonged intratumoral reten...
Mitochondrial Metabolism and Cancer
PROJECT SUMMARY/ABSTRACT Transformation of normal cells to cancer cells involves complex changes influenced by oncogenes, inactivation of tumor suppressors, and disrupted signaling...
The role of long noncoding RNAs in acute myeloid leukemia
PROJECT SUMMARY/ABSTRACT Over the past 40-years, the standard therapy for acute myeloid leukemia (AML), a highly fatal blood cancer, remains a combination of chemo drugs such as cy...
A20 and Tumor Immune Responses
Abstract Immunosuppressive and homeostatic mechanisms prevent immune cells and tissues from eliminating solid tumors, limiting the efficacy of anti-tumor immunity. Precise dissecti...
A novel immunotherapy for pancreatic cancer using micro-RNA-29a
Project Summary Pancreatic cancer is the third leading cause of cancer-related deaths in the United States with a 5-year survival rate of 12%. Despite the success of immune-modulat...
Factors Impacting Global Health: The Importance of Individualized Treatment Goals for Black Breast Cancer Survivors
Project Summary/ Abstract: This F31 award will allow Kelsey Sinclair (PI) the research training that will advance her toward her goal of becoming an independent cancer multimorbidi...
Deciphering inv3/t(3;3) Myeloid Leukemia Vulnerabilities via Proteogenomics and N-terminal Proteomics
PROJECT SUMMARY The overall objective of this proposal is to develop and apply novel proteogenomic approaches to identify therapeutic vulnerabilities of chromosome 3 rearranged mye...
Quantitative magnetic resonance imaging for non-invasive breast cancer therapy using physics-informed neural networks.
Project Summary My overarching goal is to become a biomedical engineer capable of advancing minimally invasive procedures through medical imaging and machine learning. To achieve t...
Aberrant activation of epidermal growth factor receptor signaling drives programming of an immunosuppressive brain tumor microenvironment in glioblastoma
PROJECT SUMMARY/ABSTRACT Glioblastoma (GBM) is the most common primary malignant brain tumor with a dismal prognosis that lacks effective therapeutic strategies. While the advent o...
Determinants of response to cancer immunotherapy
PROJECT SUMMARY/ABSTRACT While immunotherapy is transforming cancer treatment, the majority of patients do not achieve durable responses. We have been studying response and resista...
Upstream and downstream targeting of the SPOP ubiquitin signaling pathway in prostate cancer
PROJECT SUMMARY / ABSTRACT Prostate cancer (PCa) is a clinically and molecular heterogenous disease, with distinct subtypes. These subtypes are associated with characteristic genom...
Dissecting the role of B lineage cells in mediating response of resectable lung cancer to neoadjuvant immune-based therapy
PROJECT SUMMARY Neoadjuvant and perioperative chemoimmunotherapy are the standard of care for the treatment of patients with resectable non-small cell lung cancer (NSCLC). Unfortun...
Mechanisms of NK cell activation and immune-editing of leukemia
PROJECT SUMMARY Candidate: Dr. Jennifer Foltz’s doctoral and post-doctoral training has focused on improving natural killer (NK) cell therapy, a type of innate lymphocyte that has...
A Role of Multilevel Healthcare Access Dimensions in Ovarian Cancer Disparities
ABSTRACT Ovarian cancer accounts for more deaths than any other cancer of the female reproductive system. In 2021, there were 21,410 new cases of OC and 13,770 deaths. Remarkable p...
Novel regulation of the CDK4/Cdh1/Pin1 signaling axis for targeted breast cancer therapies
Project Summary/Abstract: The anaphase-promoting complex/Cyclosome (APC/C) is a well-defined multi-subunit E3 ubiquitin ligase that regulates targeted cell cycle regulators for deg...
Dose Linear Energy Transfer Volume Histogram and Dosimetric Seed Spot Analysis in Spot Scanning Proton Therapy
PROJECT SUMMARY/ABSTRACT Radiation therapy may induce severe adverse events (AEs), and result in significant detriment to patients’ quality of life, especially in head and neck, su...