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20,252 grants found
Showing 601 – 620 of 20,252 grants
Precision medicine for pancreatic cancer. Biomarker-guided drug delivery of platinum to tumors
This project proposes to study the effects of new platinum anticancer drugs in pancreatic cancer. We suggest that the unique combination of two research areas - the implication of...
Overcoming Therapy Resistance in Fusion Oncoprotein Driven Pediatric Leukemia
PROJECT SUMMARY Leukemia represents the most prevalent form of cancer among children. Sequencing studies from identical twins indicate that the initial genetic alterations can mani...
Engineered orthogonal signaling systems for selective phosphorylation of protein kinase substrates
ABSTRACT Protein kinases function in cell signaling through regulated phosphorylation of specific substrates. Current methods allow one to comprehensively identify the substrates o...
Symptom Monitoring using Patient-Reported Outcomes to Optimize Medication Use (SyMPTOM)
PROJECT SUMMARY For the more than 200,000 women who develop hormone receptor positive breast cancer yearly, endocrine therapy for at least five years reduces cancer recurrence by n...
Symptom Management and Transitioning to Engagement with Post-treatment Care for Adolescent and Young Adult Cancer Survivors (AYA STEPS)
There are more than 600,000 adolescent and young adult (AYA; age 15-39 at diagnosis) cancer survivors in the U.S. The number of AYA survivors continues to grow due to both an incre...
Parkin tumor suppression
PROJECT SUMMARY The loss of endogenous tumor suppressors is an obligatory step in tumor onset and progression, but the underlying mechanisms are elusive and the breadth of their ta...
Cloud/Subscription based, Customer-Responsive Dosimetry Tool for alpha-Particle Emitters
Direct to Phase 2 SBIR Cloud/Subscription based, Customer-Responsive Dosimetry Tool for α-Particle Emitters PROJECT SUMMARY Radiopharmaceutical therapy (RPT) – defined as a form of...
Identification of essential biomarkers in the polyploid cancer cell lifecycle
PROJECT SUMMARY Whole-genome duplication (WGD) is increasingly appreciated as a defining moment for enabling chromosome instability in solid tumors. This proposal investigates chem...
Novel Mcl-1 Inhibitor for Combination Treatment of Refractory Multiple Myeloma
ABSTRACT Multiple myeloma (MM) is a plasma cell malignancy. Treatment usually involves a proteasome inhibitor, dexamethasone, and an immunomodulatory or chemotherapeutic treatment,...
Interrogating the Role of Bacterial Methyl-modifying Enzymes in Pathoadaptation and Host Epigenetic Interference in Cancer
PROJECT SUMMARY/ABSTRACT The proposed study seeks to determine if DNA methyltransferases from members of the microbiota contribute to bacterial pathoadaptation in the tumor niche,...
Hijacking Post-translational Arginylation for Targeted Protein Degradation
Project summary Posttranslational arginylation on proteins installed by arginyltransferase ATE1 is a critical modification for cancer progression and metastasis. ATE1 is a benefici...
Peptoid conjugates targeting prostate cancer
PROJECT SUMMARY We propose an innovative approach to antagonize the androgen receptor (AR) by displaying AR ligands on a peptoid scaffold. This new family of molecules, called mult...
Dyadic yoga Program for Patients with Lung Cancer Undergoing Radiotherapy and their Family Caregivers
PROJECT SUMMARY/ABSTRACT Patients with lung cancer, on the most prevalent cancer diagnoses in the United States, tend to experience debilitating physical and psychological sequelae...
Reversible Biological Acetylation in Health and Disease
Program Summary We seek funding for the conference "Reversible Biological Acetylation in Health and Diseases" under the auspices of the Federation of American Societies f...
Lymphedema Prevention Through Immediate Lymphatic Reconstruction
PROJECT ABSTRACT Lymphedema is a debilitating, life-long iatrogenic sequalae of cancer treatment which is becoming an important survivorship issue due to improved cancer survival....
Increasing the efficacy of non-activated CAR T cells by modulating IFN1 signaling
Chimeric antigen receptor (CAR) T cells have demonstrated their efficacy in treating blood-based cancers. However, the durability of responses is often hindered by challenges relat...
Discovery of small molecules targeting Polycomb repressive complexes 1 and 2
Discovery of small molecules targeting Polycomb Repressive Complex 1 ABSTRACT: The discovery that mutations and dysregulation of chromatin modifiers are major cancer drivers has in...
Systems Metabolic Approach for Multi-scale Pancreatic Cancer Phenotyping
ABSTRACT Pancreatic cancer is an aggressive, painful malignancy with a 5-year survival rate of less than 5% and median survival of about 4 to 24 months. The overall lack of success...
Emerging Strategies for Therapy of Metastatic Brain Cancer
PROJECT SUMMARY Brain cancer remains a devastating disease and in particular, brain metastases (BM) from breast cancer represent the leading cause of fatality for women. The major...
Overcoming Limitations of BETInhibition in NUT Carcinoma
Project Summary/Abstract. NUT-fusion oncoproteins, most commonly BRD4-NUT, drive NUT carcinoma (NC), an aggressive, poorly differentiated squamous cancer with a 6.5-month median su...