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20,252 grants found
Showing 41 – 60 of 20,252 grants
Adaptation and Preliminary Evaluation of Energize-MBC: Cognitive Behavioral Therapy for Fatigue among Women with Metastatic Breast Cancer
PROJECT SUMMARY/ABSTRACT Our team’s long-term goal is to promote the health and well-being of “metavivors,” a growing population of individuals living long-term with metastatic can...
Determine the Role of Histone Methyltransferase ASH1L in Metastatic Prostate Cancer
Metastasis is the major cause of cancer mortality. Effective therapies are urgently needed for patients with metastatic diseases. Increasing evidence suggests that interactions bet...
Circulating metabolites as novel risk biomarkers for gastric cancer: a large multi-center prospective investigation
ABSTRACT Gastric cancer is one of the most common and deadly cancers globally, accounting for over one million new cancer diagnoses and 783,000 deaths in 2018. Infection of Helicob...
Uncovering Causal Protein Markers to Characterize Pancreatic Cancer Etiology and Improve Risk Prediction
Pancreatic cancer (PC) is the third leading cause of cancer mortality in the United States. The vast majority of PC are pancreatic ductal adenocarcinoma (PDAC). The etiology of PDA...
Distance-based Exercise to preserve Function and prevENt Disability (DEFEND)
PROJECT SUMMARY Many cancer survivors experience challenges in performing daily activities and loss of work productivity due to the adverse effects of cancer and its treatments, re...
Partners in Research: Building capacity for community-driven research to advance health equity
ABSTRACT Structural factors of health inequities are the systemic and societal conditions that contribute to disparities in health among different populations. These disparities of...
Cultivating programmatic efforts to optimize the conduct and implementation of NCI-funded clinical trials
Dr. Cathy Eng is an exemplary Clinician Scientist who, throughout her career, has held numerous roles within the National Clinical Trials Network (NCTN) and is viewed, by her peers...
Comprehensive Analysis and Multi-Omics Data Integration for Cancer-Related Studies
Project Summary/Abstract I am a principal data scientist and bioinformatics manager of The Experimental and Computational Genomics Core in the Sidney Kimmel Comprehensive Cancer Ce...
POINT of CARE: PrOviding an Innovative New Triage and Treatment strategy for Cervical cAncer scReening Efficiency
PROJECT SUMMARY Although preventable, cervical cancer is a leading cause of mortality in low- and middle-income countries (LMIC). Infection with high-risk human papillomavirus (HPV...
Novel Statistical Models for Intensive Longitudinal Analyses of Cancer Control Behaviors
PROJECT SUMMARY This project will develop, test, apply, and disseminate multilevel statistical models and software for estimating effects of intraindividual means, variances, slope...
Advancing breast cancer risk assessment for Black women
ABSTRACT Effective treatment schemes have reduced breast cancer mortality, but precise identification of women at increased risk of developing breast cancer, to personalize screeni...
Myeloma multidimensional precancer atlas
SUMMARY Multiple Myeloma (MM) is almost always preceded by monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma (SMM), with a transformation rate of ~1%...
Development of a lung cancer subtyping diagnostic
DEVELOPMENT OF A LUNG-CANCER SUBTYPING DIAGNOSTIC Abstract The overall goal of the proposed project will be to create a high sensitivity, high specificity subtyping test for lung c...
Optimizing Treatment of Co-occurring Smoking and Unhealthy Alcohol use among PWH in Nairobi, Kenya
Project Summary. Sub-Saharan Africa is home to >70% of people with HIV (PWH) globally. It is also burdened with rising rates of tobacco use, high rates of unhealthy alcohol use,...
Development of an antibody-oligonucleotide conjugate for treatment of Head and Neck Squamous Cell Carcinoma
Abstract: In this Direct to Phase II SBIR application, miRecule proposes to develop MC-30 an Antibody RNA Conjugate (ARC), composed of the anti-EGFR antibody cetuximab conjugated t...
Advancing Next Generation CAR-T cells for Renal Cell Carcinoma
Project Summary/Abstract Renal Cell Carcinoma (RCC) accounts for approximately 90% of kidney cancers in adults. Despite the advancements made in cytokine, immune checkpoint, and ta...
In vivo efficacy, safety and PK/PD analysis of SYN101, a first in class, immune cell targeted TGFb therapy for cancer patients
NCI SBIR Phase II Summary The immune checkpoint inhibitors (ICI) block a single immuno-suppressive pathway in cancer patients. However, across all cancers, less than 30% of patient...
Using gene expression to identify patients at high risk for late breast cancer recurrence
PROJECT SUMMARY Non-metastatic breast cancer is treated surgically and with adjuvant therapies. As these treatments have improved, recurrence-free survival has steadily increased,...
Preventing chemotherapy-related toxicities and infections with a novel phosphorylated triblock copolymer
PROJECT SUMMARY Covira Surgical, Inc. is developing a first-in-class agent for preventing chemotherapy-related gastrointestinal (GI) toxicities and lethal infections. Chemotherapy...
Personalized Cancer Support for Young Adults
PROJECT SUMMARY Worry and distress in cancer survivors are common, do not correlate with disease severity, and are heightened in young adults who are going through multiple life tr...