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20,252 grants found
Showing 561 – 580 of 20,252 grants
Biostatistics and Computational Biology (BCB) Core
CORE 2: BIOSTATISTICS AND COMPUTATIONAL BIOLOGY: SUMMARY/ABSTRACT The Biostatistics and Computational Biology (BCB) Core for this P01 will enable cost-effective data processing, an...
Core 3: MPIP.
CORE 3_MULTIPARAMETER IMAGING AND PATHOLOGY: SUMMARY/ABSTRACT One basic function of Core 3 includes the collection and distribution of specimens and patient samples to P01 investig...
3D In vivo dosimetry for FLASH proton therapy
ABSTRACT: This U01 application aims to (1) develop a robust protoacoustic dosimeter for 3D in vivo dosimetry in proton FLASH therapy, which is essential for its clinical applicatio...
Identifying and overcoming mechanisms of resistance to effectively target the TBL1/β-catenin signaling axis for high-risk osteosarcoma
Osteosarcoma (OS) is the most common bone malignancy in the pediatric population. Overall survival rates remain about 65-75% and are significantly worse for patients with metastati...
Addressing tumor heterogeneity in pediatric gliomas with precision adoptive T cell therapy
Project Summary Tumor-specific immunotherapy is a promising modality capable of improving clinical outcomes for children affected with high-grade glioma (HGG). We have pioneered a...
Developing liquid biopsy tests for malignant effusions using artificial intelligence-assisted, morphology-based isolation of tumor cells
PROJECT SUMMARY/ABSTRACT Background. Malignant effusions (ME) are frequent complications of metastatic breast cancer (MBC) associated with severe symptoms and dire prognosis. Treat...
Integrative Analysis and Visualization Platform for Cancer Regulatory Genomics
PROJECT SUMMARY Recent advancements in next-generation sequencing technologies have resulted in the generation of vast quantities of publicly accessible data that are specific to c...
Modulating growth, progression and metastasis in breast cancer by inhibiting MDA-9
Despite therapeutic advances, the 5-year survival rate from metastatic triple negative breast cancer (TNBC) has not improved significantly for 30-years. As such, significant benefi...
Implementing Sustainable mobile health Technology to Optimize smoking cessation Program for Lao people with HIV (I-STOP)
PROJECT SUMMARY: Tobacco use remains the leading modifiable risk factor for preventing cancer globally, particularly among people with HIV (PWH). In Lao People's Democratic Re...
Advancing novel therapeutics and translational science to close the survivorship gap in pediatric, adolescent and young adult (AYA) lymphoma
PROJECT SUMMARY/ABSTRACT: Hodgkin Lymphoma (HL) has its first incidence peak in the adolescent and young adults (AYA) years. Despite the success of chemotherapy and radiation in yo...
Washington University ACCERT center
Project Summary (Abstract) Goal: The overall goal of the WashU ACCERT is to advance cancer control equity through community - engaged multilevel research interventions that address...
Administrative Core
PROJECT SUMMARY – ADMINISTRATIVE CORE The Administrative Core will provide the structure for effective and efficient operation and maintenance of the Washington University Advancin...
Research Measures, Methods and Data Management Core
Project Summary- Research Methods, Measures, and Data Management Core The Research Methods, Measures, and Data Management (RMMDM) Core will advance the goal of the WashU-ACCERT cen...
Social Determinants of Health Research Project
Project Summary- Social Determinants of Health Multilevel Intervention Financial toxicity –hardships caused by the costs of cancer treatment– are common and have substantial impact...
Community Responsive Research Program
The overall goal of WashU-ACCERT is to advance cancer control equity through community-engaged multi- level research that addresses the impact of social determinants of health on c...
Active HCV diagnosis to support prevention of HCC in LMICs
Project Summary HCV is a major threat worldwide, infecting over 58 million people and causing 300,000 deaths from HCV-related cirrhosis or hepatocellular carcinoma (HCC) each year....
Regulation of Androgen Receptor by NXTAR Long non-coding RNA in Prostate Cancer and its Therapeutic Implications
Abstract Androgen receptor (AR) signaling continues to play a dominant role in all stages of prostate cancer (PC), including castration-resistant prostate cancers (CRPCs) that have...
Role of LAM-specific TREM1 in leukemogenesis
PROJECT SUMMARY/ABSTRACT Cancer progression is heavily influenced by supportive cells in the tumor microenvironment. Macrophages, an important component of tissue microenvironment,...
The Personalized Remote Radiation Tracking Portable Organ Dosimetry Devise (PRRT PODD)
Theranostics is a type of precision medicine in which targeted radiolabeled compounds are being used for both diagnosis and treatment. Targeted therapies can increase therapeutic e...
ExpLoiting thErapeutic VulnerAbilities in hepaTocEllular carcinoma (ELEVATE)
OVERALL: SUMMARY Hepatocellular carcinoma (HCC), the primary malignancy of hepatocytes, is a diagnosis with bleak outcomes. With the alarming rise in global obesity incidence, obes...