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20,252 grants found
Showing 541 – 560 of 20,252 grants
Leveraging Project ECHO for improved cervical cancer screening in Ethiopia: An implementation study of integrated HPV selfsampling in HIV care centers
PROJECT ABSTRACT Each year, more than 500,000 women are diagnosed with cervical cancer (CxCa), a preventable cancer caused by human papillomavirus (HPV) that disproportionately bur...
Accelerated Brachytherapy Forward Chemoradiation Therapy (ABC-RT) for Cervical Cancer
PROJECT SUMMARY Survival from cervical cancer is stagnating in the United States. Despite many intervening clinical trials, the standard of care (SOC) definitive chemoradiation the...
Prebiotic diet intervention to enhance the microbiome and immunotherapy response in melanoma
PROJECT SUMMARY Treatment with immune checkpoint inhibitors (ICI) has been revolutionary in melanoma and other cancers. However, only a subset of patients will have durable respons...
Preclinical Studies to Develop an Eya2 Tyr Phosphatase Inhibitor as a Novel Medulloblastoma Therapeutic
Medulloblastoma (MB) is the most common malignant brain tumor in children. For decades, there have not been significant advances in the treatment for MB, which still includes surge...
Activity-based Sensor Peptides for Direct, High-throughput, and Kinetic Quantitation of Oncogenic Protein Kinases in Unfractionated Cell and Tissue Samples
PROJECT SUMMARY 30 lines Protein kinases catalyze selective and timely protein phosphorylation and are essential for the normal function of all cells. Unregulated kinase activity i...
Engineering ex vivo breast tumors in human breast tissue to address racial disparities in HR-/ERBB2+ breast cancer
PROJECT SUMMARY/ABSTRACT Black women are 42% more likely to die from breast cancer than White women. While social, economic, structural, and cultural factors contribute to this dis...
Assessment of strategies for targeting transcriptional co-activators in colorectal cancer
Project Summary: PGC-1 family proteins (PGC-1α, PGC-1β, and PPRC1) are transcriptional coactivators that act as central hubs to coordinate diverse cellular inputs to promote the tr...
3D Proteomics at Single Cell Resolution with Covalent Protein Painting (CPP)
Project Summary/Abstract Somatic mutations alter the folding and therewith function of oncogene and tumor suppressor proteins. The alterations in protein structure drive malignant...
Tuning KITv CAR T cells for the solid tumor environment
PROJECT ABSTRACT We developed and translated CD28 costimulated chimeric antigen receptor (M28z CARs) T cells that target mesothelin(MSLN), a cancer-associated antigen that is overe...
Dissecting a novel tumor-promoting axis in cholangiocarcinoma
There is an urgent need to identify effective treatments for intrahepatic cholangiocarcinoma (CCA), a highly desmoplastic tumor of the bile ducts with a five-year survival rate of...
Automatic integrated biomarkers to improve prediction of lung cancer outcomes
PROJECT SUMMARY/ABSTRACT Research. Non-small cell lung cancer (NSCLC) is the world’s deadliest cancer, but patients with NSCLC can have dramatically different outcomes, illuminatin...
Immunotherapy to deplete key Treg subsets in solid tumors
Abstract Solid tumors such as non-small cell lung cancer and melanoma afflict more than 250,000 Americans per year. While immunotherapies such as checkpoint inhibitors (CPIs) have...
Epigenetic basis and therapeutic targeting of the unique lymphoma immunological niche
OVERALL: ABSTRACT Diffuse large B-cell lymphoma (DLBCL) is an aggressiveand clinically heterogeneous malignancy derived from B-cells transiting the germinal center (GC) reaction. I...
Admin Core
CORE A: ADMINISTRATIVE CORE: PROJECT SUMMARY/ABSTRACT The responsibilities of the Administrative Core include monitoring and planning of scientific activities, providing scientific...
Project 1 Melnick
PROJECT 1: ABSTRACT One of the critical unmet needs from both the scientific and therapeutic standpoints in the B-cell lymphoma field is understanding how these tumors evade the no...
Project 2 Josefowicz
PROJECT 2: SUMMARY/ABSTRACT Activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL) and Epstein Barr virus associated viral lymphomas (EBV+ lymphoma) have in common that th...
Project 3 Cerchietti
PROJECT 3: SUMMARY/ABSTRACT This project focus in the biology of diffuse large B-cell lymphoma (DLBCL) in older individuals (i.e., patients 75-years or older). Based on findings in...
Project 4 Green-Davis
PROJECT 4: ABSTRACT Diffuse large B-cell lymphoma (DLBCL) is the most common form lymphoma and is conventionally treated with a combination of chemotherapeutics with the anti-CD20...
Elucidating the mechanism of Ga13 mediated tumor suppression in pancreatic cancer
RESEARCH SUMMARY The heterotrimeric G proteins transduce signals from the G protein-coupled receptors (GPCRs), the largest class of cell surface proteins that regulate a wide varie...
Core 1: Lymphoma models
CORE 1 LYMPHOMA MODEL SYSTEMS: SUMMARY/ABSTRACT The Lymphoma Model System core (LMSC) will assemble and characterize the reagents critical for this proposal, including the vast arr...