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20,252 grants found
Showing 501 – 520 of 20,252 grants
Targeting Glioblastoma Stem Cells
PROJECT SUMMARY/ABSTRACT Glioblastoma represents one of the most lethal types of cancers. Despite extensive molecular characterization, precision medicine efforts have largely fail...
Esophageal squamous cell cancer initiation and immune landscape remodeling
PROJECT SUMMARY/ABSTRACT Esophageal squamous cell carcinoma (ESCC) is a lethal cancer with a 10%-25% 5-year survival rate. Given the importance of early detection, the initiation p...
Irradiation, Preclinical Imaging, & Microscopy (IPIM)
Project Summary/Abstract: Irradiation, Preclinical Imaging, and Microscopy The Irradiation, Preclinical Imaging, and Microscopy Shared Resource (IPIM) provides a comprehensive arra...
Immunology and Cancer Immunotherapy (ICI)
Project Summary/Abstract: Immunology and Cancer Immunotherapy The Immunology and Cancer Immunotherapy (ICI) Program brings together 21 faculty, representing seven departments at Da...
Protein arginine methyltransferase inhibitors in treatment of high-grade serous ovarian cancer and triple-negative breast cancer
PROJECT SUMMARY The expression levels of protein arginine methyltransferases (PRMTs) are significantly elevated in cancer cells and are associated with poor clinical outcomes. This...
Disrupting MDSC-fibroblast interactions to overcome chemoimmunotherapy resistance in pancreatic cancer
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy projected to be the 2nd leading cause of cancer-related deaths in the United States by 2030, with a d...
Biological and social determinants of psychosocial sequelae in advanced head and neck cancer survivors receiving immunotherapy
ABSTRACT The goal of this study is to understand psychosocial sequelae and their biological and social determinants among patients with advanced head and neck cancer (HNC) receivin...
Developing extracellular vesicle-mediated targeted microRNA delivery system for EGFR cancers
Title Developing extracellular vesicle-mediated targeted microRNA delivery system for EGFR cancers Project Summary Targeted therapy acts on a well-defined molecular mechanism of di...
Breast Cancer Diagnostic Kit to Improve Early Diagnosis in Uganda
ABSTRACT: Breast cancer in Uganda presents a pressing public health challenge, characterized by late-stage diagnoses and high mortality rates, particularly among women residing in...
Engineering Immune Engagers
PROJECT SUMMARY/ABSTRACT Natural killer (NK) cell engagers are a promising anticancer therapy that potently leverages the immune system while providing an exceptional safety profil...
Examining Tobacco Use Relapse among Cancer Survivors
PROJECT SUMMARY 1 Cancer survivors that use tobacco are at a greater risk of experiencing negative health outcomes. While many 2 cancer survivors quit using tobacco at time of diag...
Living Beyond Cancer: How Distance Impacts Childhood Cancer Survivorship Care
PROJECT SUMMARY/ABSTRACT Significance: Over 15,000 children aged
Closing the Adolescent and Young Adult Clinical Trial Enrollment Gap with an AYA (Alert, Young Adult Navigation and Alliance) Clinical Tool
Project Summary More than 80,000 adolescents and young adults (AYAs, ages 15- 39-years) are diagnosed annually with cancer in the United States, but relatively few enroll on cancer...
Defining the Role of Palliative care for Patients with Hematologic Malignancies Undergoing Adoptive Cellular Therapy
PROJECT SUMMARY Adoptive cellular therapies (ACT) such as chimeric antigen receptor T-cell therapy are complex treatments for patients with hematologic malignancies. Patients recei...
The Mass Partnership for Community-Engaged Cancer Control Equity
ABSTRACT The Massachusetts Partnership for Community-Engaged Cancer Control Equity (Mass PCECCE) builds on a robust partnership between the Harvard T.H. Chan School of Public Healt...
Admin-Core
SUMMARY - ADMINISTRATIVE CORE The Administrative Core of the Massachusetts Partnership for Community-Engaged Cancer Control Equity (Mass PCECCE is designed to provide scientific an...
Research Measures Method and Data Management Core
SUMMARY – RESEARCH METHODS, MEASURES, AND DATA MANAGEMENT CORE The Research Methods, Measures, and Data Management (RMMDM) Core of the proposed Massachusetts Partnership for Commun...
Social Determinants of Health Research Project
SUMMARY– THE COMMUNITY GATEWAY TO HEALTH EQUITY STUDY (SDOH STUDY) The Community Gateway to Health Equity Study, our SDOH study, aims to investigate the impact of a multi-level app...
Community Responsive Project
SUMMARY – COMMUNITY RESPONSIVE PROJECTS PROGRAM Although academics are well-meaning in designing studies they believe will improve health equity, they often do not have relevant li...
Investigating and Targeting Replication Stress in Small Cell Lung Cancer
PROJECT SUMMARY/DESCRIPTION Small-cell lung cancer (SCLC), accounting for about 15% of all cases of lung cancer worldwide, is the most lethal form of lung cancer. Despite an initia...