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20,252 grants found
Showing 481 – 500 of 20,252 grants
Core C: Biostatistics and Bioinformatics Core
PROJECT SUMMARY/ABSTRACT of the Biostatistics and Bioinformatics Core (BBC) The Translational Research Program in Colorectal Cancer Disparities (TRPCD) SPORE will utilize cutting-...
Developmental Research Project
PROJECT SUMMARY/ABSTRACT of the Developmental Research Program (DRP) The Developmental Research Program (DRP) will provide key support to rapidly advance new ideas that have the po...
Career Enhancement Program
PROJECT SUMMARY/ABSTRACT of the Career Enhancement Program (CEP) Our Translational Research Program in Colorectal Cancer Disparities' (TRPCD) Career Enhancement Program is an...
Functional and molecular characterization of Oncofetal Stem Cells in CRC
Functional and molecular characterization of Oncofetal Stem Cells in CRC Project Summary. Background. Colorectal cancer (CRC) is the second most deadly cancer worldwide, with nearl...
Augmented Reality to Guide Head and Neck Cancer Surgery
PROJECT SUMMARY For head and neck cancer patients, a positive surgical margin results in treatment intensification, increased cost, and an increased risk of recurrence and death. P...
Metabolic regulation of oxidative phosphorylation in pediatric AML relapse
PROJECT SUMMARY The overall goal of this research is to determine how lipid metabolism supports oxidative phosphorylation (OXPHOS) in acute myeloid leukemia (AML) stem cells. Leuke...
Elucidating mechanisms underlying NSCLC progression to leptomeningeal disease
PROJECT SUMMARY. Progression to metastatic disease from Non-Small Cell Lung Cancer (NSCLC) is a significant cause of mortality. Central nervous system (CNS) metastases, which carry...
Precision Engineering of STING-DC Immunity to Overcome Tumor Immune Evasion
Abstract Host defense responses by the mammalian immune system can be very potent but require exquisite spatio-temporal coordination. This coordination is essential to match the im...
Metabolic Reprogramming of Myeloid Cells to Enhance Cancer Immunotherapy
PROJECT ABSTRACT/SUMMARY Immunotherapy has revolutionized how oncologists treat cancer patients. One type of immunotherapy includes immune checkpoint inhibitors (ICIs), such as tho...
Pediatric Solid Tumor Microenvironment Atlas
OVERALL SUMMARY/ABSTRACT The majority of solid tumors in children have a unique origin compared to those in adults, stemming from their rise from embryonic cells. Despite this dist...
Portable, low-cost cryotherapy system that does not require consumable cryogen gas for the treatment of cervical precancerous lesions
Abstract Cervical cancer deaths have dramatically fallen in high-income countries, but cervical cancer remains one of the leading causes of cancer deaths in low- and middle-income...
Impact of Targeted Therapy on Cancer-Related Cognitive Impairment
PROJECT SUMMARY/ABSTRACT Cancer-related cognitive impairment (CRCI) is common and distressing among cancer survivors. An understudied area is the impact of targeted therapies, a ne...
Hippo Pathway in Biology and Diseases
PROJECT SUMMARY The overall goal of this proposal is to obtain funding support for early-career researchers (i.e., PhD students, postdoctoral fellows) and junior faculty to attend...
Protein Phosphatases
Abstract/Summary: Protein phosphatases play a key role in cellular signaling pathways, opposing kinase activity to dynamically balance protein phosphorylation. Despite their critic...
RISE UP for Breast Cancer
ABSTRACT RISE UP (Revolutionizing Investigations to Link Screening to Experimental Therapeutics to Upend Prognosis for Breast Cancer) will bring an interdisciplinary, prevention-fo...
A hybrid type III effectiveness-implementation, pragmatic intervention trial for cervical cancer screen and treat in Mozambique
PROJECT SUMMARY AND ABSTRACT Every year approximately 300,000 women die from cervical cancer, with over 90% of those deaths occurring in low-and middle-income countries (LMICs).1 T...
Kupewa: Optimizing strategies to implement provider recommendation of HPV vaccination for adolescent girls and young women with HIV in Malawi
Project Summary/Abstract Human papillomavirus (HPV) vaccination is a critical cancer control intervention, particularly in resource- constrained health systems with limited access...
The Impact of an Evidence-Based, Behavioral Cervical Cancer Screening Intervention among Women Living with HIV in Ghana (HOPE-inG): A Type 2 Hybrid Effectiveness Implementation Trial
ABSTRACT Over 69,000 women living with HIV, (WLWH) in Ghana have a six-fold increased risk of developing cervical cancer1 and require early and frequent cervical cancer screening (...
Implementation of Screen, Treat, and Triage for Women Living with HIV in La Romana (iSTAR)
PROJECT SUMMARY Cervical cancer is preventable, yet it remains one of the most common causes of cancer-related death in women in low- and middle-income countries (LMICs). Few disea...
ENHANcing CErvical cancer screening and treatment in women LIviNg with HIV in KenyA (ENHANCE LINKAge)
ABSTRACT In sub-Saharan Africa (SSA), human papillomavirus (HPV) and HIV create a dual burden of disease that causes significant morbidity and mortality in the form of cervical can...