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20,252 grants found
Showing 461 – 480 of 20,252 grants
Multiplexed, Continuous Reporting of Gene Expression via CRISPR-mediated Transcriptional Activation
PROJECT SUMMARY: Although the detection of gene expression by quantitative PCR, bulk or single cell RNA sequencing represents a cornerstone of biological inquiry, these approaches...
A novel platform for targeted radiopharmaceuticals for imaging and therapy of ovarian cancer
Project Summary The goal of this Phase I STTR is to continue development of Oncurie’s novel ovarian cancer targeting compound, which binds to the folate receptor and delivers radio...
Development of ablative therapy for the destruction of cervical neoplasia
PROJECT SUMMARY Cervical intraepithelial neoplasia (CIN) is caused by the sexually transmitted Human Papilloma Virus (HPV), which infects 14 million women in the US every year and...
OPC SURVIVOR: Optimizing OroPharyngeal Cancer SURVIVORship
ABSTRACT: OVERALL Oropharyngeal cancer (OPC) is rising in epidemic proportions, largely owing to rise in highly curable oncogenic human papillomavirus (HPV) attributable disease. H...
Core A: Administrative
ABSTRACT: CORE A (ADMIN) The Administrative Core proposes to provide centralized administrative management and strategic oversight of integration of the OPC-SURVIVOR Program. The a...
Project 1: OPC-ORN
ABSTRACT: PROJECT 1 (OPC-ORN) Current standard-of-care external beam radiotherapy (EBRT) for human papillomavirus (HPV)-associated oropharyngeal cancer (OPC) offers high cure at th...
Project 2: OPC-NERVE
ABSTRACT: PROJECT 2 (OPC-NERVE) While most patients with oropharyngeal cancer (OPC) present with near normal functioning at the time of diagnosis, a growing number of survivors suf...
Project 3: OPC-RAD
ABSTRACT: PROJECT 3 (OPC-RAD) Modern-day X-ray–based radiation therapy (IMRT), given with chemotherapy, has improved survival outcomes for patients with oropharyngeal squamous cell...
Core B: Clinical Informatics & Analytics
ABSTRACT: CORE B (CLINICAL INFORMATICS & ANALYTICS) The central hypothesis of this proposed OPC-SURVIVOR P01 is to improve lifelong quality of life (QOL) and health among oroph...
Core C: Patient-Reported Outcomes & Function (PROF)
ABSTRACT: CORE C (PROF) Based on over 8-years of successful longitudinal, prospective patient-centered outcomes data collection in oropharynx cancer (OPC) survivors supporting data...
Inhibiting beta-adrenergic and COX-2 signaling during the perioperative period to reduce ovarian cancer progression
Inhibiting beta-adrenergic and COX-2 signaling during the perioperative period to reduce ovarian cancer progression Abstract: The short perioperative period, days before and after...
Translational Cancer Biology (TCB) T32 Training Program
Abstract The problem of cancer in the 21st century remains a national priority, and as such, offers a substantive long-term career opportunity for pre-doctoral and post-doctoral tr...
Genetic and Environmental basis of Cancer Risk and Disparities (GECaRD)
Abstract This proposal is for a new T32 predoctoral program to train the next generation of multi-disciplinary cancer researchers with the expertise to unravel the complexity of fa...
Translational Research Program in Colorectal Cancer Disparities
PROJECT SUMMARY/ABSTRACT – Overall Racial and ethnic disparities in colorectal cancer (CRC) are particularly pronounced in African American and Alaska Native people. These differen...
Core A: Administrative Core
PROJECT SUMMARY/ABSTRACT – Administrative Core (AC) In our currently active Translational Research Program in Colorectal Cancer Disparities (TRPCD) funded as a P20 SPORE planning g...
Project 1: Racial and ethnic differences in the intra-tumoral microbiome: Impact on colorectal cancer mortality and clinicopathologic correlates
PROJECT SUMMARY/ABSTRACT of Project 1 Colorectal cancer (CRC) is one of the leading causes of cancer death, and it disproportionately impacts African American people whose CRC mort...
Project 2: Discovery and validation of novel molecular and immune predictors of colorectal cancer mortality and response to treatment in racially and ethnically diverse patient populations
PROJECT SUMMARY/ABSTRACT Disparities in colorectal cancer (CRC) incidence and mortality are appreciable and continue to persist in the United States particularly among Alaska Nativ...
Project 3: Racial and ethnic differences in the intra-tumoral microbiome: Impact on colorectal cancer mortality and clinicopathologic correlates
PROJECT SUMMARY/ABSTRACT Colorectal cancer (CRC) incidence and mortality vary greatly by race and ethnicity in the United States (US). Alaska Native people have among the highest r...
Project 4: Effect of Meal Timing during Cancer Treatment in Alaska Native Patients - A Randomized Clinical Trial
PROJECT SUMMARY/ABSTRACT – Project 4 A promising strategy for reducing toxicity and improving the efficacy of anticancer treatments involves combining treatment with fasting regime...
Core B: Biospecimen and Pathology Core
PROJECT SUMMARY/ABSTRACT of the Biospecimen and Pathology Core (BPC) The Biospecimen and Pathology Core (BPC) of the Translational Research Program in Colorectal Cancer Disparities...