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20,252 grants found
Showing 441 – 460 of 20,252 grants
Project 2: BRCA1-dependent DNA End Resection and Regulation via the 53BP1 Axis
PROJECT SUMMARY/ABSTRACT DNA double strand breaks (DSBs) are induced by genotoxic agents such as ionizing radiation, chemotherapeutic agents, and during encounters of the DNA repli...
Redefining indications of EGFR inhibitors in cancers that harbor mutant RAS
Background: Anti-EGFR agents have been shown to benefit colorectal cancer patients, except for patients whose tumor includes a KRAS mutation. Data from multiple clinical trials sug...
Investigating the Pathogenic Role of Tubulin Post-translational Modifications in CIPN
SUMMARY Chemotherapy induced peripheral neuropathy (CIPN) is the most prevalent neurological complication of oral or intravenous chemotherapy. Approximately 50–90% of patients unde...
The role of acute excitation of sensory neurons in the development of paclitaxel-induced peripheral neuropathy
Project summary/Abstract: Paclitaxel-induced peripheral neuropathy (PIPN) and associated neuropathic pain is a significant adverse effect experienced by cancer patients who receive...
Prehabilitation Exercise Training in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation
PROJECT SUMMARY Multiple myeloma is the second most prevalent hematologic malignancy in the US with an estimated 7.1 cases per 100,000. Patients diagnosed with multiple myeloma hav...
The role of mesothelial-derived cancer-associated fibroblasts in the pathogenesis of pancreatic ductal adenocarcinoma
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDA) is a deadly disease with a five-year survival rate of 12%. Oncogenic KRAS (Kras*) is a near-universal driver of PDA, and its...
Mechanisms of endocrine therapy and radiation synergism to decrease brain metastases
PROJECT SUMMARY The increasing number of young women diagnosed with metastatic breast cancer has awakened the urgency to define why they are more likely to suffer from aggressive b...
Defining the Mechanistic Impact of PRC1 Overexpression on Mammalian Spindle Mechanics
Project Summary/Abstract Errors in chromosome segregation lead to aneuploidy, a hallmark of cancer. While we know nearly all molecules involved in mammalian cell division, we do no...
Characterizing Oncogenic Nras in IDH1 Mutant AML Leukemogenesis and Therapeutic Responsiveness
PROJECT SUMMARY/ABSTRACT Acute Myeloid Leukemia (AML) is a lethal hematologic malignancy characterized by impaired myeloid differentiation and blast proliferation, inhibiting norma...
Investigating the role of FOXA1/2 and HNF4⍺ in Pancreatic ductal adenocarcinoma
PROJECT ABSTRACT Cell identity, crucially controlled by transcription factors (TFs), is perturbed in cancer, contributing to highly aggressive and metastatic tumors, such as pancre...
Harnessing human gut-derived Bacteroides to drive systemic anti-tumor immunity
Although immune checkpoint blockade has transformed therapeutic options for lung cancer, its efficacy differs widely even between patients with remarkably similar disease, and whil...
Improving the Assessment of Patient-reported Outcomes among Black/African-American Cancer Patients
Project Summary Willi L. Tarver is an Assistant Professor in the Division of Cancer Prevention and Control, College of Medicine at The Ohio State University. Dr. Tarver is respondi...
Identification of splice variant derived neo-antigens in head and neck squamous cell carcinoma as targets for tumor vaccine therapy
Title: Identification of splice variant derived neo-antigens in head and neck squamous cell carcinoma as targets for tumor vaccine therapy Abstract Immune checkpoint inhibitors (IC...
Towards a Comprehensive, Spatiotemporal Roadmap of Cancer Metastasis
PROJECT SUMMARY Cancer metastasis, which accounts for 8 million deaths worldwide annually, is a multistep process that includes the emergence of metastatic subclones in primary tum...
Defining the landscape of bacterial-colonized microniches in tumors and their role in intratumoral heterogeneity.
PROJECT SUMMARY/ABSTRACT Within a patient’s tumor, malignant cells are surround by a complex and dynamic collection of cell types, which includes the intratumoral microbiota. Howev...
Social Genomic Mechanisms Linking Structural Racism, Perceived Discrimination, and Breast Cancer Survival
PROJECT SUMMARY Women living in historically redlined neighborhoods impacted by structural racism and discrimination (SRD) have shorter breast cancer (BCa) recurrence-free survival...
Evolved Molecules that Destroy Cancer Relevant Proteins
ABSTRACT Cancer research is often driven by hypotheses that postulate that a specific protein is important for the disease, hypotheses often tested by adding an antibody to that sy...
Resolving transcription factor target search mechanisms
Project Summary Proper gene expression regulation is pivotal for cellular function, and its dysregulation contributes to disease. Transcription factors (TFs) initiate gene expressi...
Bio-orthogonal Mid-Infrared Photothermal Imaging of Cancer Metabolism
Project Summary Understanding how cancer cells reprogram their metabolism and interact with other biological processes to gain aggressiveness and/or resistance to a treatment is of...
Quantification of molecular interactions across the matrix spectrum enables cancer research.
Project Summary We propose to further develop, refine, and validate our emerging free-solution assay (FSA) technology and our relatively new compensated Interferometric reader (CIR...