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20,252 grants found
Showing 421 – 440 of 20,252 grants
Comparison of convection enhanced delivery systems in a randomized controlled clinical study of recurrent Grade 3-4 glioma patients
Project Abstract Significance: The devasting outcomes for glioblastoma (GBM) patients remain despite the advances in cancer therapy. Improved GBM therapy as a critical unmet need r...
Dual-targeting allogeneic CAR T-cells for universal therapy of T-cell malignancies
Abstract Relapsed and refractory T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoma (TCL) are aggressive hematologic malignancies with limited therapeutic options and...
Developing a Novel Biologic Therapy to Eradicate Brain Cancer and Brain Metastasis
PROJECT SUMMARY Brain cancers are the leading cause of disease-related death in children and in adults under the age of 40-years old. Even with aggressive treatments that include m...
Improving allocation of scarce medical physics resources through a novel, comprehensive quality assurance device.
Healthcare disparities in the US result in large segments of the population without access to radiation therapy (RT). This manifests itself in Eastern Kentucky and Appalachia, wher...
Diversity Supplement: Cheminformatics-based identification of leukemia-targeting molecules
Contact PD/PI: Kirienko, Natasha V SUMMARY Acute myeloid leukemia (AML) is the most common acute leukemia in the US, with ~20,000 new diagnoses and ~11,000 deaths per year. This pe...
Local Flavor Policies to Enhance Equity in Tobacco - A Diversity Supplement
ABSTRACT Policies restricting the sale of flavored tobacco products (FTP) are being enacted in localities around the US. We seek to expand the evidence base about the extent to whi...
Administrative supplement to expand cancer clinical trial capacity in sub-Saharan Africa
PROJECT SUMMARY/ABSTRACT This application is being submitted in response to the Notice of Special Interest (NOSI) identified as “NOT-CA-24-039.” Cancer mortality rates are projecte...
Bright IDEAS-Young Adults: Problem-Solving Skills Training to Reduce Distress among Young Adults with Cancer
Project Summary/Abstract This application is being submitted in response to the Notice of Special Interest (NOSI) identified as “NOT-CA- 24-041: Administrative Supplements for Asse...
Social Health, Activity Behaviors, and Quality of Life among Young Adult Cancer Survivors: A longitudinal Study Administrative Supplement
Abstract This application is being submitted in response to the Notice of Special Interest (NOSI) identified as "NOT-CA- 24-041.” A growing population of survivors of young ad...
Cancer Center Support Grant - Gunn Supplement
Abstract/Project Summary: This application is being submitted in response to the Notice of Special Interest (NOSI) identified as "NOT-CA-24-041.” Dartmouth Cancer Center (DCC)...
Improving Survivorship Care for Adolescents and Young Adults: a Mixed Methods Study of Alignment with the National Standards for Survivorship Care
PROJECT SUMMARY/ABSTRACT This application is being submitted in response to the Notice of Special Interest (NOSI) identified as "NOT-CA- 24-041”. This proposal aims to investi...
Development of a precision medicine platform for circadian based therapeutics in pancreatic cancer
Abstract Pancreatic ductal adenocarcinoma (PDA) is among the most fatal of all cancers, and is on track to become the second-leading cause of cancer-related death in the US by 2030...
Metabolic and epigenetic reprogramming in cyclin E high ovarian cancer
Project Summary/Abstract This application is being submitted in response to the Notice of Special Interest (NOSI) identified as “NOT-CA- 24-044”.The ultimate goal of this proposal...
The impact of reduction of cellular senescence on age-related epigenetic heterogeneity
PROJECT SUMMARY Acute myeloid leukemia (AML) occurs mostly in adults 65-years and older and is associated with age-related clonal hematopoiesis (CH). This condition that results fr...
Preclinical models of serous endometrial cancer from diverse patient populations
Project Summary / Abstract: This administrative supplement is in response to the Notice of Special Interest (NOSI): Administrative Supplements for the Study of the Diverse Aspects...
Novel Integrative Approach for the Early Detection of Lung Cancer using Repeated Measures
This application is being submitted in response to the Notice of Special Interest (NOSI) identified as “NOT-CA- 24-058.” Lung cancer remains the leading cause of cancer-related dea...
A Mobile Web App Intervention to Promote Cervical Cancer Screening among Indigenous Women
Project Summary Our overarching goal is to increase the rates of cervical cancer (CC) screening among Indigenous women in the U.S. This population experiences disproportionately hi...
Surgical Oncology Research Training at Indiana (SORTI)
SUMMARY Surgeon-scientists are an underrepresented population in academic medicine, and federally funded physician- scientist-led research has been in decline over the past decade....
A Multilevel Data Analytic Solution to Advance Population Cancer Research
Project Summary/Abstract The proposed work will develop a first-of-its-kind, transportable informatics tool, the Population Cancer Assessment and Surveillance Engine (Pop-CASE), th...
Project 1: Role of DYNLL1 in the 53BP1 Axis of HDR Regulation
ABSTRACT Double stranded DNA break (DSB)s are repaired by two major mechanistically distinct pathways, DNA homology-directed repair (HDR) and non-homologous end joining (NHEJ). A d...