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20,252 grants found
Showing 4,221 – 4,240 of 20,252 grants
Platform to develop targeted therapies for aggressive less common gynecological cancers
PROJECT SUMMARY Gynecological malignancies such as uterine cancers [e.g carcinosarcomas, papillary serous carcinoma, and leiomyosarcomas (LMS)] and ovarian cancers [e.g low-grade s...
Pilot Projects-Tran-Network
Summary: The goals of the Pilot Projects and Trans-Network Activities Core of the UP-PDTC focus on two priorities. First, the Core will promote and support new Pilot Projects with...
Advancing Precision Lung Cancer Surveillance and Outcomes in Diverse Populations (PLuS2)
Due in part to recent advances in screening and treatment, the 5-year relative survival rate for patients with early-stage non-small cell lung cancer (NSCLC), the leading cause of...
Ligand-Directed KRAS G12V Mutant-Specific Therapeutics
Project Summary The proto-oncogene KRAS is one of the most critical genes in cancer, yet, as a drug target, it has proven to be among the most elusive. A remarkable 30% of lung ade...
Water-based liquid embolic agent for the treatment of vascular rich tumors
AquaTeX Medical is developing a novel liquid embolic material (LEM) - Aqua Embolic System (AES) - to improve cancer treatment. AES is designed to occlude feeding vessels of hyperva...
Vitamin B6 Modulates NK Cell Metabolism in Pancreatic Cancer
Project Summary: The poor survival rates in pancreatic ductal adenocarcinoma patients are in part due to poor response to existing therapies. Thus, there is an urgent need to devel...
Exposing the role of MYC in small cell carcinoma of the ovary hypercalcemic type
PROJECT SUMMARY/ABSTRACT SCCOHT is rare and often fatal ovarian cancer, with the average age of diagnosis being around 24-years old. The molecular pathogenesis of SCCOHT is overwhe...
Breast core-needle diagnostics in LMICs via millifluidics and direct-to-digital imaging: development and validation in Ghana
ABSTRACT Breast cancer is an increasing challenge globally as it became the most prevalent malignancy at the end of 2020. More than 70% of all cancer mortality now occurs in low- a...
VLA-4–targeted 67Cu-LLP2A preconditioning enhances efficacy of T-cell-based adoptive immunotherapy
Project Summary & Abstract Adoptive T cell therapies (ACT) including chimeric antigen receptor (CAR) T cells are novel immunotherapies with unparalleled successes, especially i...
University of Pennsylvania Patient-derived Xenograft Development and Trials Center
Project Summary/Abstract: The overall goal of the University of Pennsylvania PDX Development and Therapeutics Center (UP-PDTC) is to (i) exploit the translational potential of PDX...
University of Pennsylvania Patient-derived Xenograft Development and Trials Center
Summary: The goal of the Administrative Core of the University of Pennsylvania PDX Development and Trials Center is primarily to facilitate innovative translational science that wi...
PDX Core
Summary: The PDX Core of the UP-PDTC is the primary experimental laboratory of the extensive xenotransplantation program at the University of Pennsylvania (UPENN). Research into hu...
Bioinformatics Core
Summary: The Bioinformatics Core is the primary data management and analysis arm of the UP-PDTC. Of note, the Bioinformatics Core will include biostatistics, bioinformatic and data...
Acute myeloid leukemia (AML) Research Project
Summary Acute myeloid leukemia (AML) is one of the most intensely studied of human malignancies. In recent years there have been major advances in defining the molecular pathogenes...
Platform to develop targeted therapies for aggressive less common gynecological cancers
PROJECT SUMMARY Gynecological malignancies such as uterine cancers [e.g carcinosarcomas, papillary serous carcinoma, and leiomyosarcomas (LMS)] and ovarian cancers [e.g low-grade s...
Pilot Projects-Tran-Network
Summary: The goals of the Pilot Projects and Trans-Network Activities Core of the UP-PDTC focus on two priorities. First, the Core will promote and support new Pilot Projects with...
Advancing Precision Lung Cancer Surveillance and Outcomes in Diverse Populations (PLuS2)
Due in part to recent advances in screening and treatment, the 5-year relative survival rate for patients with early-stage non-small cell lung cancer (NSCLC), the leading cause of...
Optimizing CAR T therapy via metabolic engineering for thetreatment of GBM
PROJECT SUMMARY AND ABSTRACT Significance: Glioblastoma (GBM) is an extremely devastating disease with reported median survivals ranging from 13 to 73 months and 5-year survivals o...
Biomarker guided combinations for treating high-risk bladder cancer
Bladder cancer (BC) is a common cancer of the urinary tract. While low-grade tumors have a good prognosis, two-thirds of patients with high-grade BC have tumors invading the bladde...
Selective Radionuclide Delivery for Precise Bone Marrow Niche Alterations
PROJECT SUMMARY / ABSTRACT The bone marrow niche houses hematopoietic stem cells (HSCs), cells that self-renew and differentiate into vital blood components like white blood cells,...