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20,252 grants found
Showing 4,181 – 4,200 of 20,252 grants
Administrative and Biostatistics Core
PROJECT SUMMARY – Administrative and Biostatistics Core The overall goal of the Administrative and Biostatistics Core (Admin Core) is to facilitate research efforts toward understa...
Core 1: Tumor and Microenvironment Heterogeneity Core (TMH Core)
PROJECT SUMMARY – Core 1: Tumor and Microenvironment Heterogeneity Core The central hypothesis driving efforts of the TMH Core is that immune and other stromal cells in the tumor m...
Core 2: Human Specimen and Organic Core (HSO Core)
PROJECT SUMMARY – Core 2: Human Specimen and Organoid Core Patients diagnosed with pancreatic ductal adenocarcinoma (PDA) often fail to respond to therapeutic intervention or rapid...
Core 3: Mouse Models Core (MM Core)
PROJECT SUMMARY – Core 3: Mouse Models Core The Mouse Models Core (MM Core) will provide essential, value-added services in support of all P01 projects. As all projects propose pre...
Divergent Functions of ERK Substrate Binding Domains in Pathogenesis of Myeloproliferative Neoplasms
PROJECT SUMMARY/ABSTRACT The Ras/MAPK pathway is activated in 85% of human cancer. Nevertheless, attempts to target Ras/MAPK signaling have produced only limited efficacy. We hypot...
Discovery and characterization of exceptionally specific surface oncoprotein LIPI in Ewing Sarcoma
Project Summary Children and young adults with metastatic Ewing sarcoma driven by oncogenic fusion transcription factor EWS- FLI1 continue to have poor outcomes. Immunotherapies us...
The role of inflammation in the regulation of immune response in acute myeloid leukemia
Project Summary/Abstract Survival outcomes of acute myeloid leukemia (AML) patients are negatively affected by high inflammation in the bone marrow compared to low inflammation pat...
Inhibition and Catalytic Degradation of Promutagenic DNA Deaminases
PROJECT SUMMARY This proposal aims to develop the first potent and specific antagonists of the pro-mutagenic effects of APOBEC DNA deaminase enzymes in cells. Access to whole genom...
Evaluating an evidence-based family history screening program adapted to increase reach and uptake of screening for BRCA-associated cancers in rural public health clinics
PROJECT SUMMARY Brief and low-cost family history-based screening assessments to identify families at high risk for BRCA- associated cancers have been endorsed by national guidelin...
The role of translation initiation factor eIF5B in lung cancer pathogenesis
PROJECT SUMMARY Lung cancer cells express high levels of PD-L1, a ligand of the PD-1 receptor on T-cells, allowing tumors to directly suppress T cell activity. Anti-PD-1/PD-L1 anti...
PLK1 and EGFR targeted nanoconstruct as a monotherapy and a radiation sensitizer for lung cancer
Lung cancer is the leading cause of cancer mortality, exceeding deaths from colon, breast, and prostate cancers combined. Resistance to chemo and targeted therapy is very common. R...
Overcoming mechanisms of therapeutic resistance in pancreatic ductal adenocarcinoma
PROJECT SUMMARY – Overall While mortality rates for many cancers are declining, pancreatic ductal adenocarcinoma (PDA) remains a highly lethal malignancy with the worst 5-year surv...
Project 1: Overcoming therapeutic resistance in pancreatic cancer through epigenetic reprogramming
PROJECT SUMMARY – Project 1: Epigenetics Pancreatic ductal adenocarcinoma (PDA) is a devastating disease with a disturbing rise in incidence. The poor prognosis of PDA is attribute...
Project 2: Targeting signaling networks to overcome therapeutic resistance in pancreatic cancer
PROJECT SUMMARY – Project 2: Signaling Pancreatic ductal adenocarcinoma (PDA) is most commonly diagnosed at late stages, at which time the disease is refractory to most conventiona...
Project 3: The AMPK Autophagy Pathway as a Metabolic Liability in Pancratic Ductal Adenocarcinoma
PROJECT SUMMARY – Project 3: Autophagy Pancreatic ductal adenocarcinoma (PDA) is one of the deadliest forms of cancer with few effective therapies. The poor performance of current...
Administrative and Biostatistics Core
PROJECT SUMMARY – Administrative and Biostatistics Core The overall goal of the Administrative and Biostatistics Core (Admin Core) is to facilitate research efforts toward understa...
Core 1: Tumor and Microenvironment Heterogeneity Core (TMH Core)
PROJECT SUMMARY – Core 1: Tumor and Microenvironment Heterogeneity Core The central hypothesis driving efforts of the TMH Core is that immune and other stromal cells in the tumor m...
Core 2: Human Specimen and Organic Core (HSO Core)
PROJECT SUMMARY – Core 2: Human Specimen and Organoid Core Patients diagnosed with pancreatic ductal adenocarcinoma (PDA) often fail to respond to therapeutic intervention or rapid...
Core 3: Mouse Models Core (MM Core)
PROJECT SUMMARY – Core 3: Mouse Models Core The Mouse Models Core (MM Core) will provide essential, value-added services in support of all P01 projects. As all projects propose pre...
Discovery and characterization of exceptionally specific surface oncoprotein LIPI in Ewing Sarcoma
Project Summary Children and young adults with metastatic Ewing sarcoma driven by oncogenic fusion transcription factor EWS- FLI1 continue to have poor outcomes. Immunotherapies us...