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20,252 grants found
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Advancing Analysis and Interpretation of Adverse Events and PROs in Cancer Clinical Trials
ABSTRACT In this application and program of research, we will collaborate with the NRG Oncology Statistical Center to develop analytic and graphical strategies to investigate novel...
A Biobehavioral Intervention to Reduce Adverse Outcomes in Young Adult Testicular Cancer Survivors
Project Abstract Testicular cancer diagnosis and treatment, especially given its threat to sexuality and reproductive health, can be distressing in the formative period of young ad...
Dual targeting of PI3K and NOS pathways in Metaplastic BreastCancer (MBC)
ABSTRACT Metaplastic breast cancer (MpBC) is a rare subset accounting for
PIK3CA signaling and pancreatic cancer
The goal of this proposal is to explore how to target PIK3CA signaling for treatment of pancreatic ductal adenocarcinoma (PDAC). This deadly cancer is highly resistant to current t...
Targeting FASN to eliminate metastatic breast cancer in the brain
Summary Metastatic breast cancer in the brain is a deadly disease and the second most tumor incidence in the central nervous system. Although improvement of cancer treatments with...
Assessing residential neighborhood exposome exposures and the associations with cancer incidence
Colorectal, lung, and female breast cancers are major public health burdens and there are clear geographic and racial/ethnic disparities in their incidence. Each of these cancers h...
3' tsRNAs: biologic function and pre-clinical targeting for treating human disease
ABSTRACT Over the last decade we characterized and studied the properties of various tRNA derived small RNAs (tsRNAs). In recent years, we have focused on one class commonly referr...
Mechanisms Promoting Copper Dependent Cell Death in Cancer
PROJECT SUMMARY Copper is an essential co-factor for enzymes across the animal kingdom yet even modest intracellular concentrations can be toxic, resulting in cell death. The toxic...
The role of focal adhesion kinase in therapy resistant prostate tumors
Abstract Treatment-induced neuroendocrine prostate cancer (t-NEPC) is a subgroup of prostate tumors with poor patient outcomes. Beyond systemic chemotherapy and palliative care, no...
A Novel VpreB1 Anti-body Drug Conjugate for the Treatment of B-Lineage Acute Lymphoblastic Leukemia/Lymphoma
A Novel VpreB1 Antibody-Drug Conjugate for the Treatment of B-Lineage Acute Lymphoblastic Leukemia/Lymphoma B-cell acute lymphoblastic leukemia (B-ALL) is the most common malignanc...
Epigenetic regulation of pancreatic cancer subtype identity and tumorigenesis by PHF2
Molecular subtyping of pancreatic ductal adenocarcinoma (PDAC) has defined two major transcriptional subtypes, Classical and Basal-like, which are presently the most powerful predi...
Impact of RB activation on the pancreatic cancer epigenome and tumor microenvironment
Pancreatic ductal adenocarcinoma (PDAC) represents a therapy recalcitrant disease with 5-year survival rate of approximately 10%. Multiple failed clinical trials reinforce the need...
A Phase 2, Single-Arm Study of the CXCR1/2 Inhibitor SX-682 Plus Enzalutamide in Men with Abiraterone-Resistant Metastatic Castration Resistant Prostate Cancer (mCRPC)
Prostate cancer (PC) is the second leading cause of cancer-related death among American men, and the vast majority of these deaths are due to metastatic, castration-resistant PC (m...
Neutrophil derived proteinases abolish the IFNG signature in NSCLC
ABSTRACT Although immune checkpoint inhibitor (ICI) therapy has been a tremendous clinical success, just ~20% of non- small cell lung cancer (NSCLC) patients respond to anti-PD1/PD...
Profiling the Fluid Assisted Dissemination of Pre-malignant cells in Fallopian Tubes
PROJECT SUMMARY The high mortality rate in ovarian cancers is explained in part, by late-stage clinical diagnosis where intraperitoneal tumor burden is already prevalent and widesp...
Identifying lethal prostate cancer at diagnosis with advanced proteoglycomic, radiomic, and genomic approaches
PROJECT SUMMARY Conventional prostate adenocarcinoma (PCa) is the second leading cause of cancer death in American men. Patients with organ-confined disease are candidates for pote...
EBNA1 Inhibitor for Treatment of EBV-positive DLBCL
PROJECT SUMMARY The Epstein-Barr Virus (EBV) is responsible for approximately 200,000 new cancer cases each year worldwide. Among these, EBV+ Diffuse Large B-Cell Lymphoma (DLBCL)...
HER1-3 and Death Receptor protein folding as therapeutic vulnerabilities
Breast cancer remains a major killer of women due to the ineffectiveness of current drugs against metastatic and drug-resistant cancers. Additionally, African American (AA) women s...
Integrating Clinical, Pathologic, and Immune Features to Predict Breast Cancer Recurrence and Chemotherapy Benefit
Abstract Breast cancer is the leading cause of cancer death for women globally, with over 2.3 million cases diagnosed each year. Most cases are hormone receptor positive and effect...
Targeting RAGE in tumor and TME to oppose inflammation and drug resistance in obesity associated ER+ breast cancer
PROJECT SUMMARY/ABSTRACT Obesity is associated with increased postmenopausal estrogen receptor-positive (ER+) breast cancer (BC) risk and a 2-4 fold increase in mortality from all...