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20,252 grants found
Showing 4,121 – 4,140 of 20,252 grants
Targeting intracrine steroidogenesis in anti-androgen resistant prostate cancer
PROJECT ABSTRACT Prostate cancer (PCa) is the second leading cause of cancer related death in men in the United States in 2022. A limit number of PCa cell lines and patient-derived...
Integrating imaging and biopsy-derived molecular markers for the pre-surgical detection of indolent and aggressive early stage lung adenocarcinoma
ABSTRACT Lung adenocarcinoma (LUAD) is the most common lung cancer subtype diagnosed in the US; characterized by a broad spectrum of biological behaviors and clinical trajectories....
Mechanisms of mutant p53 reactivation
PROJECT SUMMARY The tumor suppressor protein p53 is the most frequently mutated protein in human cancers. About 600,000 new cancer patients in the United States are diagnosed each...
Dietary fatty acids drive pancreatic cancer development
PROJECT SUMMARY/ABSTRACT Despite significant advances in cancer care, pancreatic ductal adenocarcinoma (PDAC) remains the third leading cause of cancer death in the United States w...
siRNA-based Gold Nanoparticles as a Therapeutic Enhancer for Triple Negative Breast Cancer (TNBC) Radiotherapy
ABSTRACT Radiation therapy (RT) modulates immunological properties of tumor microenvironment (TME) to stimulate antitumor immune response. However, RT initiates immunosuppressive m...
Deciphering the role of NELFE in modulating MYC signaling in HCC
ABSTRACT Hepatocellular carcinoma (HCC) is an aggressive tumor type with poor prognosis due to the diverse etiology, tumor heterogeneity, and the frequent late stage diagnosis. HCC...
Substrate Specificity Determinants in Nutrient Solute Carrier Transporters
SUMMARY Alterations in cell metabolism support rapid growth and proliferation of cells in pathologies such as cancer, au- toimmune disease, and heart ischemia, resulting in increas...
Colorectal Cancer (CRC) Prevention by Urolithin A in Rodent CRC models
Colorectal cancer (CRC) is the third most common cancer diagnosed in the United States as per the current estimates of The American Cancer Society.The number of CRC cases in the Un...
Dietary fatty acids drive pancreatic cancer development
PROJECT SUMMARY/ABSTRACT Despite significant advances in cancer care, pancreatic ductal adenocarcinoma (PDAC) remains the third leading cause of cancer death in the United States w...
The Role of Mortalin in Thyroid Cancer
The goal of this project is to elucidate the mechanism by which mortalin is upregulated in thyroid cancer, determine the role of mortalin for tumor cell metabolism, and evaluate th...
Targeting FASN to eliminate metastatic breast cancer in the brain
Summary Metastatic breast cancer in the brain is a deadly disease and the second most tumor incidence in the central nervous system. Although improvement of cancer treatments with...
PIK3CA signaling and pancreatic cancer
The goal of this proposal is to explore how to target PIK3CA signaling for treatment of pancreatic ductal adenocarcinoma (PDAC). This deadly cancer is highly resistant to current t...
Characterization of the Regulation and Gene Targets of TBX2 in Rhabdomyosarcoma
My lab is focused on understanding the molecular events that result in the transition of a skeletal muscle precursor cell to a rhabdomyosarcoma (RMS) tumor cell in hopes to suggest...
Assessing residential neighborhood exposome exposures and the associations with cancer incidence
Colorectal, lung, and female breast cancers are major public health burdens and there are clear geographic and racial/ethnic disparities in their incidence. Each of these cancers h...
Mechanisms promoting copper dependent cell death in cancer
PROJECT SUMMARY Copper is an essential co-factor for enzymes across the animal kingdom yet even modest intracellular concentrations can be toxic, resulting in cell death. The toxic...
3' tsRNAs: biologic function and pre-clinical targeting for treating human disease
ABSTRACT Over the last decade we characterized and studied the properties of various tRNA derived small RNAs (tsRNAs). In recent years, we have focused on one class commonly referr...
A Biobehavioral Intervention to Reduce Adverse Outcomes in Young Adult Testicular Cancer Survivors
Project Abstract Testicular cancer diagnosis and treatment, especially given its threat to sexuality and reproductive health, can be distressing in the formative period of young ad...
Dual targeting of PI3K and NOS pathways in Metaplastic BreastCancer (MBC)
ABSTRACT Metaplastic breast cancer (MpBC) is a rare subset accounting for
Understanding Treatment Tolerability in Older Patients with Cancer
PROJECT SUMMARY The overarching goal of this grant proposal supplement, submitted on behalf of the University of Rochester NCI Community Oncology Research Program (UR NCORP) Resear...
Analyzing and Interpreting PRO-CTCAE with CTCAE and Other Clinical Data to Characterize Drug Tolerability
PROJECT ABSTRACT In cancer clinical trials, it is essential to understand and communicate the negative impact of drugs on patient participants in order to balance risks and benefit...