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The Rigor and Clinical Utility of PSMA Enriched Extracellular Vesicles for Prostate Cancer Detection
Screening for prostate cancer saves lives but results in an overwhelming number of men being subjected to unnecessary, invasive prostate biopsies, and the risk of over diagnosis an...
Aging trajectories and outcomes of older adults with acute myeloid leukemia
PROJECT SUMMARY In the US, over one-third of older adults ≥60-years with acute myeloid leukemia (AML) die without receiving any chemotherapy, primarily due to concerns of cognitive...
Targeting LKB1-null lung adenocarcinoma with innate immune system
Project Summary The tumor suppressor LKB1 is one of the most frequently mutated genes in lung adenocarcinoma (LUAD). This tumor subgroup is resistant to immune checkpoint blockade...
Developing novel therapy to improve outcomes in MCL
PROJECT SUMMARY Mantle cell lymphoma (MCL) is an incurable non-Hodgkin lymphoma, and despite intensive therapeutic approaches, the median progression-free survival after first-line...
Targeting neuronal transport to ameliorate vincristine neurotoxicity
Abstract Microtubule-binding chemotherapeutics such as vincristine are among the most widely used anticancer agents in oncology for the treatment of multiple solid tumors and leuke...
Secretory Mitophagy in Cancer Metabolic Reprogramming
Tumor metabolic reprogramming is a hallmark of cancer progression, survival, and therapeutic resistance. A targetable class of cancer metabolic adaptation exploits mitophagy, a spe...
Elucidating the Cellular Origins of lung adenocarcinoma
Lung cancer is responsible for the most cancer-related deaths in the United States, and Lung adenocarcinoma (LUAD) is the major histologic subtype. LUAD presents clinically with fo...
Neural organoid models of the immunological microenvironment of glioblastoma for drug discovery applications
Project Summary/Abstract Glioblastoma (GBM) is the most prevalent primary brain tumor in adults with extremely poor survival rates and largely unchanged standard of care. While the...
Targeting neuronal transport to ameliorate vincristine neurotoxicity
Abstract Microtubule-binding chemotherapeutics such as vincristine are among the most widely used anticancer agents in oncology for the treatment of multiple solid tumors and leuke...
Secretory Mitophagy in Cancer Metabolic Reprogramming
Tumor metabolic reprogramming is a hallmark of cancer progression, survival, and therapeutic resistance. A targetable class of cancer metabolic adaptation exploits mitophagy, a spe...
Integrating imaging and biopsy-derived molecular markers for the pre-surgical detection of indolent and aggressive early stage lung adenocarcinoma
ABSTRACT Lung adenocarcinoma (LUAD) is the most common lung cancer subtype diagnosed in the US; characterized by a broad spectrum of biological behaviors and clinical trajectories....
Targeting intracrine steroidogenesis in anti-androgen resistant prostate cancer
PROJECT ABSTRACT Prostate cancer (PCa) is the second leading cause of cancer related death in men in the United States in 2022. A limit number of PCa cell lines and patient-derived...
Analysis of ECOG-ACRIN adverse event data to optimize strategies for the longitudinal assessment of tolerability in the context of evolving cancer treatment paradigms (EVOLV)
Project Summary EVOLV proposes to deliver sophisticated and standardized methods for assessing, monitoring, analyzing, and reporting adverse events (AEs) experienced by individuals...
The Role of Mortalin in Thyroid Cancer
The goal of this project is to elucidate the mechanism by which mortalin is upregulated in thyroid cancer, determine the role of mortalin for tumor cell metabolism, and evaluate th...
Mechanisms of mutant p53 reactivation
PROJECT SUMMARY The tumor suppressor protein p53 is the most frequently mutated protein in human cancers. About 600,000 new cancer patients in the United States are diagnosed each...
siRNA-based Gold Nanoparticles as a Therapeutic Enhancer for Triple Negative Breast Cancer (TNBC) Radiotherapy
ABSTRACT Radiation therapy (RT) modulates immunological properties of tumor microenvironment (TME) to stimulate antitumor immune response. However, RT initiates immunosuppressive m...
Dietary fatty acids drive pancreatic cancer development
PROJECT SUMMARY/ABSTRACT Despite significant advances in cancer care, pancreatic ductal adenocarcinoma (PDAC) remains the third leading cause of cancer death in the United States w...
Substrate Specificity Determinants in Nutrient Solute Carrier Transporters
SUMMARY Alterations in cell metabolism support rapid growth and proliferation of cells in pathologies such as cancer, au- toimmune disease, and heart ischemia, resulting in increas...
Understanding Immunotype, a Novel Biomarker for Checkpoint Blockade Resistance
ABSTRACT An estimated 44% of patients with cancer in the United States are eligible to receive immune checkpoint blockade (ICB). FDA-approved ICB agents include α-PD-1 and α-CTLA-4...
Deciphering the role of NELFE in modulating MYC signaling in HCC
ABSTRACT Hepatocellular carcinoma (HCC) is an aggressive tumor type with poor prognosis due to the diverse etiology, tumor heterogeneity, and the frequent late stage diagnosis. HCC...