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20,252 grants found
Showing 4,081 – 4,100 of 20,252 grants
Landscape and characterization of promoter mutations driving triple-negative breast cancer
PROJECT SUMMARY Triple-negative breast cancer (TNBC) is traditionally associated with fewer identified genetic changes than other subtypes, precluding therapies that target tumor-s...
The Helicase and Nucleic Acid-based Machines Conference: Structure, Mechanism, Regulation and Roles in Human Diseases
Project Summary/Abstract The goal of this application is to obtain funding to support the biennial FASEB conference Helicases and Nucleic Acid-Based Machines: Structure, mechanism,...
Dual Kinase and LSD1 Inhibition in Acute Myeloid Leukemia
PROJECT SUMMARY/ABSTRACT Kinase inhibitor therapy has made a minimal impact on the clinical treatment of patients with Acute Myeloid Leukemia (AML). We have shown that inhibition o...
Intersection of autophagy and vesicle trafficking in Her2-positive breast cancer
Breast cancer is the most common malignancy among US women and remains a major health threat with high incidence and lethality due to therapeutic resistance and metastasis. Breast...
An urinary drug disposing approach for treatment of bladder Cancer
Project Summary Most bladder cancer (BC) patients are diagnosed at an early stage. More than 80% of cases are non-muscle invasive BC (NMIBC). The standard treatment involves removi...
Landscape and characterization of promoter mutations driving triple-negative breast cancer
PROJECT SUMMARY Triple-negative breast cancer (TNBC) is traditionally associated with fewer identified genetic changes than other subtypes, precluding therapies that target tumor-s...
Improving Understanding of Quality End of Life Care Using a Dyadic Approach
Project Summary/Abstract There is strong national consensus about the need to deliver high-quality care at the end of life (EOL) for patients with advanced (distant metastasis) can...
Investigating the role of melanoma-adipocyte cell junctions in heterotypic communication and tumor progression
PROJECT SUMMARY Melanoma is the most lethal skin cancer. Few treatment options exist for patients with metastatic disease. Upon tumorigenesis, melanoma cells invade into dermal and...
Multidimensional analyses to improve PSMA-RPT efficacy in mCRPC
Summary/Abstract While prostate-specific membrane antigen-targeted radiopharmaceutical therapy (PSMA-RPT) improves the survival of metastatic castration-resistant prostate cancer (...
Developing novel therapy to improve outcomes in MCL
PROJECT SUMMARY Mantle cell lymphoma (MCL) is an incurable non-Hodgkin lymphoma, and despite intensive therapeutic approaches, the median progression-free survival after first-line...
Integrating Multiple Electronic Health Records Systems to Improve Lung Cancer Outcomes
Recent advances in screening and treatment have increased the number of lung cancer (LC) survivors (~571,340 LC survivors as of 2019). However, studies have shown that these surviv...
Aging trajectories and outcomes of older adults with acute myeloid leukemia
PROJECT SUMMARY In the US, over one-third of older adults ≥60-years with acute myeloid leukemia (AML) die without receiving any chemotherapy, primarily due to concerns of cognitive...
Re-engineering differential regulation of ferroptosis in melanoma microenvironment
Project Summary Melanoma is an aggressive and highly metastatic skin cancer. Although modern combination checkpoint inhibitors revolutionized clinical outcomes in advanced cases, o...
The Rigor and Clinical Utility of PSMA Enriched Extracellular Vesicles for Prostate Cancer Detection
Screening for prostate cancer saves lives but results in an overwhelming number of men being subjected to unnecessary, invasive prostate biopsies, and the risk of over diagnosis an...
Role of Gastrokine 2 in pancreatic cancer development
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest adult cancers with a 5-year survival rate of only 11% and is one of the top five leading causes of cancer-r...
Targeting LKB1-null lung adenocarcinoma with innate immune system
Project Summary The tumor suppressor LKB1 is one of the most frequently mutated genes in lung adenocarcinoma (LUAD). This tumor subgroup is resistant to immune checkpoint blockade...
Role of Gastrokine 2 in pancreatic cancer development
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest adult cancers with a 5-year survival rate of only 11% and is one of the top five leading causes of cancer-r...
Multidimensional analyses to improve PSMA-RPT efficacy in mCRPC
Summary/Abstract While prostate-specific membrane antigen-targeted radiopharmaceutical therapy (PSMA-RPT) improves the survival of metastatic castration-resistant prostate cancer (...
Re-engineering differential regulation of ferroptosis in melanoma microenvironment
Project Summary Melanoma is an aggressive and highly metastatic skin cancer. Although modern combination checkpoint inhibitors revolutionized clinical outcomes in advanced cases, o...
Integrating Multiple Electronic Health Records Systems to Improve Lung Cancer Outcomes
Recent advances in screening and treatment have increased the number of lung cancer (LC) survivors (~571,340 LC survivors as of 2019). However, studies have shown that these surviv...